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Hedyotis hedyotidea traditional Chinese medicine preparation, preparation method and application of hedyotis hedyotidea traditional Chinese medicine preparation

A traditional Chinese medicine preparation, the technology of oxbaiteng, which is applied in the directions of pharmaceutical formulations, non-central analgesics, antipyretics, etc., can solve the problem of lack of, unable to slow down or prevent rheumatoid arthritis bone damage and joint degeneration, with large side effects And other issues

Pending Publication Date: 2020-05-08
SHANTOU UNIV MEDICAL COLLEGE +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the drugs used to treat rheumatoid arthritis are western medicines, which have large side effects, and cannot slow down or prevent bone damage and joint degeneration in rheumatoid arthritis. Therefore, at this stage, there is a lack of drugs that can truly effectively control the development of the disease

Method used

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  • Hedyotis hedyotidea traditional Chinese medicine preparation, preparation method and application of hedyotis hedyotidea traditional Chinese medicine preparation
  • Hedyotis hedyotidea traditional Chinese medicine preparation, preparation method and application of hedyotis hedyotidea traditional Chinese medicine preparation
  • Hedyotis hedyotidea traditional Chinese medicine preparation, preparation method and application of hedyotis hedyotidea traditional Chinese medicine preparation

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Experimental program
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Embodiment 1

[0025] Preparation of Niubateng traditional Chinese medicine preparation:

[0026] (1) Add 200g of Niubateng to 1500g of distilled water, at 30~50 o Soak at C for 1.5~2.5h;

[0027] (2) The soaking liquid obtained in the step (1) was mixed at 100 o C under reflux extraction 2 times, each reflux time is 1 ~ 3h, combined two extracts;

[0028] (3) Adjust the pH value of the extract between 5 and 6, add 2.5g of chitosan, stir for 2 to 3 hours, let it stand for 2 to 3 hours, and centrifuge the supernatant after standing to remove the precipitate to obtain Niubateng water Extraction solution;

[0029] (4) Concentrating the water extract of Caulis Alba to the state of extract to obtain the Caulis Alba extract;

[0030] (5) Mixing the extract of Caulis alba with medicinal excipients to obtain the traditional Chinese medicine preparation of Caulis alba;

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Abstract

The invention provides a hedyotis hedyotidea traditional Chinese medicine preparation, a preparation method and application of the hedyotis hedyotidea traditional Chinese medicine preparation. The preparation method of the hedyotis hedyotidea traditional Chinese medicine preparation comprises the following steps: (1) adding hedyotis hedyotidea into distilled water, and soaking the hedyotis hedyotidea for 1.5-2.5 hours at the temperature of 30-50 DEG C; and (2) performing reflux extraction on the soaking liquid obtained in the step (1) twice at the temperature of 100 DEG C, wherein every refluxtime is 1-3 hours; and merging the two-time extracting solutions. The prepared hedyotis hedyotidea traditional Chinese medicine preparation can inhibit joint swelling of a rat with rheumatoid arthritis and inhibit RAW 264.7 cells from releasing inflammatory factors; and furthermore, the hedyotis hedyotidea traditional Chinese medicine preparation inhibits differentiation of spleen lymphocytes toTh1 cells and promotes differentiation to Treg cells, and can be used for treating the rheumatoid arthritis.

Description

technical field [0001] The invention relates to the field of ethnic medicines, in particular to a traditional Chinese medicine preparation of Niubateng, a preparation method and an application thereof. Background technique [0002] Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent synovitis and progressive damage to articular cartilage, and its pathogenesis is unknown. The clinical manifestations are mainly joint pain, swelling, activity swelling, and morning stiffness. At present, most of the drugs used to treat rheumatoid arthritis are western medicines, which have severe side effects, and cannot slow down or prevent bone damage and joint degeneration in rheumatoid arthritis. Therefore, at this stage, there is a lack of drugs that can truly effectively control the progression of the disease. Contents of the invention [0003] In order to overcome the deficiencies of existing western medicines, the main purpose of the present ...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61P19/02A61P29/00
CPCA61K36/74A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P19/02A61P29/00
Inventor 陈一村李春泉林泳冰陈潮升王树芸
Owner SHANTOU UNIV MEDICAL COLLEGE
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