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A kind of Korean medicine prescription composition for treating rheumatoid arthritis and preparation method of cream

A rheumatoid and cream technology, applied in the field of ethnic medicine, can solve the problems of product volatility and stability, inconvenient transportation and poor patient compliance, etc., to improve body weight and arthritis score, good stability and moisture retention, The effect of suppressing joint swelling

Active Publication Date: 2021-08-31
延边山宝科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the original dosage tincture contains a large amount of ethanol, there are disadvantages such as inconvenient transportation and carrying, strong smell, poor patient compliance, volatile stability of the product, etc.

Method used

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  • A kind of Korean medicine prescription composition for treating rheumatoid arthritis and preparation method of cream
  • A kind of Korean medicine prescription composition for treating rheumatoid arthritis and preparation method of cream
  • A kind of Korean medicine prescription composition for treating rheumatoid arthritis and preparation method of cream

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0042] Experimental Example 1 Extraction Technology Research

[0043] 1.1 Analysis of API ingredients

[0044] The main herbs in the prescription are Scutellaria baicalensis, Rhubarb, Fangfeng, Asarum, Tripterygium wilfordii, etc. Studies have shown that Scutellaria baicalensis has strong anti-inflammatory and antibacterial activities, mainly including flavonoids, of which baicalin can inhibit the production of inflammatory factors in microglial cells induced by OGD by regulating the TLR4 signaling pathway. The flavonoids in rhubarb can reduce blood viscosity, thereby enhancing microcirculation, and have the effect of promoting blood circulation; Fangfeng has the effects of relieving exterior wind, expelling wind and relieving pain, and the chromones contained in it are the main components of its medicinal effect. Substances, such as acteoside, 5-O-methyl visamidol glycoside, etc., the lignin components in Asarum have antipyretic, analgesic and anti-inflammatory effects, and ...

experiment example 2

[0079] Experimental example 2 preparation prescription research

[0080] Cream refers to a homogeneous semi-solid preparation formed by dissolving or dispersing a drug in an emulsion-type base. The cream can not only overcome the disadvantages of oily matrix that is not easy to absorb water, poor drug release and difficult to clean, but also improve the effect of water-soluble matrix on skin protection and lubrication. The cream has a suitable consistency, is easy to apply, is not easy to melt, is easy to clean, has little effect on the normal physiological activity of the skin, has an uncomplicated production process, low production cost, and has no special requirements for production conditions. The active ingredients of this product contain two types: water-soluble and fat-soluble, and are used to treat rheumatic arthralgia. Therefore, it is not suitable to use a closed and poorly permeable oil-based matrix, nor a water-soluble matrix that is easy to lose water. , it is su...

experiment example 3

[0150] Experimental example 3 preparation process research

[0151] The quality of cream is closely related to the preparation process. Many creams often have a serious impact on the quality and stability of the cream due to the unreasonable selection of a certain parameter in the preparation process. According to literature research and preliminary tests, it was found that the four factors of stirring speed, emulsification temperature, emulsification time, and emulsifier addition method had a great influence on the quality of the cream, so the single factor investigation was carried out on these four factors.

[0152] 3.1 Investigation of stirring speed

[0153] In this experiment, different stirring speeds (150r min -1 、250r·min -1 、350r·min -1 、450r·min -1 ) on the quality of cream. Prepare the cream according to the method under "2.2.3", and make a comprehensive score according to the standards under "2.3". The inspection results are shown in Table 16. The results s...

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Abstract

The invention provides a Korean medicine prescription composition for treating rheumatoid arthritis and a preparation method thereof. Composition raw material medicinal taste: 7-9 parts of Scutellaria baicalensis, 5-7 parts of Astragalus, 2-4 parts of Tripterygium wilfordii, 1-3 parts of Asarum, 3-5 parts of Chuandilong, 3-5 parts of Qiannianjian, 3-5 parts of Fangfeng 2 to 4 parts of frankincense, 2 to 4 parts of myrrh, 3 to 5 parts of cassia twig, 3 to 5 parts of Atractylodes macrocephala, 3 to 5 parts of Sperancus, 3 to 5 parts of licorice, and 3 to 5 parts of pepper. Cream preparation prescription: 15-25 parts of concentrated medicinal solution prepared by the composition, 7-11 parts of white petrolatum, 0.5-1.5 parts of lanolin, 6-10 parts of liquid paraffin, 3-7 parts of glyceryl monostearate, hard 5.5 to 7.5 parts of fatty acid, 10 to 20 parts of glycerin, 2 to 6 parts of Tween 80, 0.5 to 1.5 parts of laurocaprazine, 0.03 to 0.07 parts of ethylparaben, and water to 100 parts. The preparation method: the composition is extracted, concentrated, mixed with the concentrated liquid medicine and base, emulsified, paste-made, filled, packaged, and the product is obtained. Experiments show that the product of the invention has the medicinal effect of treating rheumatoid arthritis.

Description

technical field [0001] The invention belongs to the field of ethnic medicines, and in particular relates to a Korean medicine composition for rheumatoid arthritis, and the preparation method and application of the cream for external use. Background technique [0002] Rheumatoid Arthritis (Rheumatoid Arthritis, RA) is a common chronic autoimmune disease with chronic, symmetrical and aggressive characteristics. In the early stage, the symptoms mainly manifest as joint pain, local redness, swelling, burning, and dysfunction. Multiple systems are damaged, seriously endangering the life and health of patients. Therefore, the prevention and treatment of RA has important theoretical and social significance. [0003] Currently, there is no specific drug that can cure RA. Western medicine treatment of RA is based on human anatomy and physiology, focusing on local and microscopic research, and mainly controls inflammation by killing bacteria, inhibiting viruses, analgesic, anti-all...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K36/8964A61P19/02A61P29/00
CPCA61K9/0014A61K9/107A61K36/185A61K36/238A61K36/268A61K36/284A61K36/324A61K36/328A61K36/37A61K36/47A61K36/481A61K36/484A61K36/539A61K36/54A61K36/81A61K36/888A61K36/8945A61K36/8964A61K47/44A61K2236/333A61K2236/51A61K2300/00
Inventor 郭建鹏许灵善杜秉权
Owner 延边山宝科技发展有限公司
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