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Application of andrographolide in drugs for treatment of acute gouty arthritis

A technology of andrographolide, acute gout, applied in the medical field, can solve the problems such as the application of andrographolide has not yet been reported and the like

Inactive Publication Date: 2018-11-27
THE WENDENG OSTEOPATH HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But there is no report about the application of andrographolide in the treatment of acute gouty arthritis

Method used

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  • Application of andrographolide in drugs for treatment of acute gouty arthritis
  • Application of andrographolide in drugs for treatment of acute gouty arthritis
  • Application of andrographolide in drugs for treatment of acute gouty arthritis

Examples

Experimental program
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Embodiment 1

[0013] Example 1 Constructing an acute gouty arthritis rat model and performing different interventions

[0014] 1 Preparation of sodium urate solution: Take 194ml distilled water, add 6ml NaOH (1mmol / L), add 1g uric acid after boiling, adjust pH to 7.2 with 1mmol / L HCL, stir and cool, place in 4°C refrigerator for 24h, remove supernatant solution, filter the precipitate with filter paper, dry the precipitate naturally to obtain sodium urate crystals, and filter it with a metal mesh sieve with a pore size of 250um. Before the experiment, the sodium urate crystals were placed in a high-temperature sterilizer at 180°C for 3 hours, then washed with ethanol with a volume fraction of 95%, centrifuged at 2000r / min for 15 minutes three times, and dried naturally at room temperature. Take 500mg of sodium urate crystals on a super-clean bench and add 9ml Physiological saline, 1ml Tween 80, heated and stirred to make 10ml 50mg / ml sodium urate solution.

[0015] 2 Experimental grouping ...

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PUM

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Abstract

The invention relates to the field of medical treatment, in particular to application of andrographolide in drugs for treatment of acute gouty arthritis. An acute gouty arthritis rat model is used forresearch, and results show that andrographolide can significantly inhibit joint swelling of the arthritis model after being infused into the stomach of a rat, inflammatory cell infiltration in the synovial membrane and synovial fluid is lower than that in a blank control group and a colchicine treatment group, the efficacy of andrographolide is not weaker than that of colchicine, there are few complications, and the use safety is high. It is found that andrographolide can effectively alleviate and treat acute gouty arthritis.

Description

technical field [0001] The invention relates to the medical field, in particular to the application of andrographolide in the medicine for treating acute gouty arthritis. Background technique [0002] Gout is a group of clinical syndromes in which the blood uric acid level increases due to purine metabolic disorders and / or decreased uric acid excretion, and monosodium urate crystals (MUC) deposit in tissues or organs and cause tissue damage. Episodic joint redness, swelling, heat, pain and dysfunction, even joint deformity, nephrolithiasis and uric acid nephropathy. Epidemiological data show that the incidence of gout is increasing year by year worldwide. At present, anti-inflammatory and analgesic drugs are mainly used in the clinical treatment of acute attack of gout, supplemented by alkalized urine therapy. Traditional effective anti-inflammatory and analgesic drugs include non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and sugar Corticosteroids. The tradit...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P19/02A61P19/06A61P29/00
CPCA61K31/365A61P19/02A61P19/06A61P29/00
Inventor 严伟李磊邹德宝林乐琴姜红江鞠昌军
Owner THE WENDENG OSTEOPATH HOSPITAL
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