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A kind of pharmaceutical composition and application thereof for the treatment of hyperuricemia

A technology for hyperuricemia and a composition, applied in the field of medicine, can solve problems such as large side effects and poor treatment effect, and achieve the effects of improving medication safety and reducing medication risks

Active Publication Date: 2018-10-16
江西博屾医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the technical deficiencies of the existing drugs for treating hyperuricemia with relatively large side effects and poor therapeutic effect, the present invention provides a pharmaceutical composition for treating hyperuricemia, which consists of a compound of formula I and puerarin

Method used

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  • A kind of pharmaceutical composition and application thereof for the treatment of hyperuricemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 compound tablet

[0021] Puerarin

[0022] Preparation process: mix puerarin and the compound of formula I with auxiliary materials microcrystalline cellulose and starch evenly, add appropriate amount of 15% starch slurry to make soft material, and then granulate through a 16-mesh sieve. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

Embodiment 2

[0023] The preparation of embodiment 2 compound tablet

[0024] Puerarin

[0025] Preparation process: except that the components are different, the preparation process is the same as that described in Example 1.

Embodiment 3

[0026] The preparation of embodiment 3 compound dispersible tablets

[0027] Puerarin

[0028] Preparation process: Weigh puerarin and the compound of formula I according to the prescription, use microcrystalline cellulose as filler, croscarmellose sodium and polyvinylpyrrolidone as disintegrants, and 5% PVP 60% ethanol solution as adhesive Agent, micronized silica gel as a flow aid, granulated in one step in a fluidized bed, and then compressed into tablets.

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Abstract

The invention relates to a pharmaceutical composition for treatment of hyperuricemia and an application thereof, and belongs to the technical field of medicines. In order to overcome technical defects that existing drugs for treating the hyperuricemia are larger in side effects, and poor in treatment effects, the invention provides the pharmaceutical composition for the treatment of the hyperuricemia. The pharmaceutical composition is composed of a compound of a formula I and puerarin. The two drug active components have significant synergistic effects in inhibiting the joint swelling of a rat model of gout and decreasing the value of blood uric acid, so that the pharmaceutical composition has a good treatment effect on the hyperuricemia.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating hyperuricemia and an application thereof, belonging to the technical field of medicine. Background technique [0002] Hyperuricemia refers to the supersaturated state of urate in the extracellular fluid. Hyperuricemia should be considered when the blood urate is ≥ 416umol / L in men and ≥ 357umol / L in women. Hyperuricemia is divided into two categories: primary and secondary. Primary hyperuricemia is caused by increased uric acid production, decreased excretion, or both. Gout is a clinical syndrome caused by urate crystal deposition. It is characterized by hyperuricemia, manifested as recurrent arthritis, tophi formation, and joint deformities. Involvement of the kidneys can cause chronic interstitial nephritis and uric acid. Nephrolithiasis, severe cases may cause joint disability and renal insufficiency. Therefore, uric acid-lowering treatment is very necessary. Gout is caused by pur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4196A61K31/352A61P19/06
CPCA61K31/352A61K31/4196A61K2300/00
Inventor 商祥淑
Owner 江西博屾医疗器械有限公司
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