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Preparation method of medical stone with epsilon-polylysine antibacterial coating layer loaded on surface

A technology of polylysine and surface loading, which is applied in chemical instruments and methods, sterilization/microdynamic water/sewage treatment, water/sludge/sewage treatment, etc. Secondary pollution, secondary pollution of water quality, etc., to achieve the effect of eliminating secondary pollution, high safety, and easy raw materials

Active Publication Date: 2020-05-08
JIANGXI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there is an obvious problem in using medical stone to purify water, that is, the secondary pollution of water quality
Because in the process of medical stone treatment of water, the microorganisms adsorbed by the medical stone can multiply rapidly on the surface of the medical stone, thus covering the surface of the medical stone. On the one hand, the adsorption capacity of the medical stone is reduced, and on the other hand, the microbial Large numbers of breeding cause secondary pollution of water quality
In the prior art, metal ions are loaded onto medical stones as bacteriostatic agents. There are medical stones such as silver-loaded, aluminum-loaded, and iron-loaded stones, but these metal ion bacteriostatic agents are not resistant to water erosion, and the dissolution rate is high, which is easy to cause metal ions. secondary pollution of ions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The invention provides a kind of preparation method of the medical stone of surface loading epsilon-polylysine bacteriostatic coating, comprises the following steps:

[0034] S1. Use absolute ethanol as a solvent to make 3-aminopropyltriethoxysilane into an amination solution with a concentration of 3%, and add 0.3% glacial acetic acid as a catalyst. The particle size is 60-80 mesh, and the surface The medical stone with microporous structure characteristics is immersed in the amination solution, the mass volume ratio of the medical stone to the amination solution is 30:100g / mL; the temperature is controlled at 60°C, reacted for 24h, and then Use a 100-mesh sieve to filter out the aminated medical stone, rinse with absolute ethanol for 10 minutes, then rinse with distilled water for 30 minutes, and dry at 105°C;

[0035] S2, the glutaraldehyde solution with a concentration of 25% is configured into a glutaraldehyde solution with a concentration of 2.5% with distilled wa...

Embodiment 2

[0039] The invention provides a kind of preparation method of the medical stone of surface loading epsilon-polylysine bacteriostatic coating, comprises the following steps:

[0040] S1. Use absolute ethanol as a solvent to make 3-aminopropyltriethoxysilane into an amination solution with a concentration of 1%, and add 0.1% glacial acetic acid as a catalyst. The particle size is 60-80 mesh, and the surface The medical stone with microporous structure is immersed in the amination solution, the mass volume ratio of the medical stone to the amination solution is 20:100g / mL; the temperature is controlled at 50°C, reacted for 48h, and then Use a 100-mesh sieve to filter out the aminated medical stone, rinse with absolute ethanol for 10 minutes, then rinse with distilled water for 30 minutes, and dry at 105°C;

[0041] S2, the glutaraldehyde solution with a concentration of 25% is configured into a glutaraldehyde solution with a concentration of 1.5% with distilled water, and sodium ...

Embodiment 3

[0045] The invention provides a kind of preparation method of the medical stone of surface loading epsilon-polylysine bacteriostatic coating, comprises the following steps:

[0046] S1. Use absolute ethanol as a solvent to make 3-aminopropyltriethoxysilane into an amination solution with a concentration of 3%, and add 0.1% glacial acetic acid as a catalyst. The particle size is 60-80 mesh, and the surface The medical stone with microporous structure characteristics is immersed in the amination solution, the mass volume ratio of the medical stone to the amination solution is 50:100g / mL; the temperature is controlled at 60°C, reacted for 24h, and then Use a 100-mesh sieve to filter out the aminated medical stone, rinse with absolute ethanol for 10 minutes, then rinse with distilled water for 30 minutes, and dry at 105°C;

[0047] S2, the glutaraldehyde solution with a concentration of 25% is configured into a glutaraldehyde solution with a concentration of 3% with distilled wate...

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Abstract

The invention provides a preparation method of medical stone loaded with an epsilon-polylysine antibacterial coating on the surface, wherein the preparation method comprises the following steps: S1, carrying out amination treatment on medical stone by using a 3-aminopropyltriethoxysilane solution to prepare aminated medical stone; S2, performing aldehyde modification on the aminated medical stoneprepared in the step S1 by adopting a glutaraldehyde solution to prepare aldehyde medical stone; S3, placing the aldehyde medical stone prepared in the step S2 in an epsilon-polylysine solution, carrying out a Schiff alkalization reaction, and thus obtaining medical stone loaded with epsilon-polylysine in the form of Schiff base; and S4, putting the medical stone loaded with epsilon-polylysine andprepared in the step S3 into a sodium borohydride solution, carrying out a reduction reaction, and reducing Schiff base to prepare the stable epsilon-polylysine loaded medical stone. The epsilon-polylysine loaded by the method provided by the invention is stable and reliable in antibacterial property, and has a great application prospect and good economic and social benefits.

Description

technical field [0001] The invention relates to the technical field of medical stone materials, in particular to a preparation method of medical stone with ε-polylysine antibacterial coating on its surface. Background technique [0002] Medical stone is a natural silicate mineral, which is non-toxic and harmless to organisms and has certain biological activity. The main chemical composition of medical stone is inorganic aluminosilicate, and it also has a special porous sponge-like structure, which has strong adsorption force and water purification effect, and is widely used in water purification and other fields. [0003] However, there is an obvious problem in using medical stone to purify water, which is the secondary pollution of water quality. Because in the process of medical stone treatment of water, the microorganisms adsorbed by the medical stone can multiply rapidly on the surface of the medical stone, thus covering the surface of the medical stone. On the one hand...

Claims

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Application Information

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IPC IPC(8): C02F1/50C02F1/28B01J20/26B01J20/30
CPCB01J20/12B01J20/262C02F1/281C02F1/285C02F1/50
Inventor 阳文静游清徽蔡险峰徐贤柱王曼莹
Owner JIANGXI NORMAL UNIVERSITY
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