Anti-aging composition comprising lactic acid bacteria-derived extracellular vesicle

A composition and anti-aging technology, which can be used in medical preparations containing active ingredients, skin care preparations, cosmetics, etc., and can solve the problems of undisclosed anti-aging effects

Active Publication Date: 2020-06-02
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the anti-aging effect of extracellular vesicles as a physiologically active complex substance derived from lactic acid bacteria has not been disclosed

Method used

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  • Anti-aging composition comprising lactic acid bacteria-derived extracellular vesicle
  • Anti-aging composition comprising lactic acid bacteria-derived extracellular vesicle
  • Anti-aging composition comprising lactic acid bacteria-derived extracellular vesicle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1. Isolation of extracellular vesicles derived from lactic acid bacteria

[0086] In this example, a Lactobacillus strain obtained from green tea was used as lactic acid bacteria, and extracellular vesicles containing exosomes were isolated therefrom. More specifically, Lactobacillus plantarum APsulloc 331261 (Accession No.: KCCM11179P) was used to prepare extracellular vesicles derived from lactic acid bacteria.

[0087] (Step 1) Centrifuge the cultivated Lactobacillus strain culture solution at 1800×g for 20 minutes at 4° C. to separate and remove the Lactobacillus strain from the culture solution. In other words, cells and supernatant are separated by a low-speed centrifugation process.

[0088] (Step 2) Centrifuge the culture medium centrifuged in step 1 at 10000×g for 20 minutes at 4° C. by high-speed centrifugation to further remove cells or cell-related debris and residues.

[0089] (Step 3) Filter the culture solution centrifuged in step 2 through a 0....

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Abstract

Disclosed in the specification is an anti-aging composition comprising, as an effective ingredient, extracellular vesicles that are complex physiologically active substances derived from lactic acid bacteria. The extracellular vesicles may be exosome-like vesicles with a diameter of 20 to 200 nm and the composition inhibits the expression of MMP-1 protein, thereby providing the effects of reducingskin wrinkles, improving skin elasticity, suppressing collagen reduction, and preventing ultraviolet light-induced skin damage.

Description

technical field [0001] The present disclosure relates to an antiaging composition comprising extracellular vesicles derived from lactic acid bacteria as an active ingredient. Background technique [0002] Matrix metalloproteinase (hereinafter referred to as "MMP") is a zinc-containing endopeptidase capable of decomposing macromolecules such as collagen, proteoglycan, and gelatin, and is mainly divided into collagenase, gelatinase, stromelysin, and membrane Type MMP. Since MMPs cause skin aging, if MMPs are inhibited, effects of treating and preventing wrinkles can be expected. In addition, MMPs promote angiogenesis, cancer invasion and metastasis through the breakdown of basement membrane. [0003] Collagen present in the dermis of the skin accounts for approximately 70% to 80% of the dry weight of the skin and is known to control skin elasticity together with elastin, which is an elastic fiber. MMPs play an important role in reducing collagen and are involved in the brea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61Q19/00A61Q19/08A61Q17/04
CPCA61K8/99A61Q17/04A61Q19/08A61K8/14A61K2800/782
Inventor 金完日曹恩敬李泰龙
Owner AMOREPACIFIC CORP
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