Extraction method of whole components of cassia seeds

An extraction method, cassia seed technology, is applied to medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, pharmaceutical formulas, etc., which can solve the problems of easy damage and difficult extraction of ingredients, and achieve improved extraction rate and high Extraction rate, easily repeatable results

Inactive Publication Date: 2020-06-05
广州泽力医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, cassia seed is mostly extracted by a single extraction method to obtain some components. If it is extracted with an organic solvent, such as after extracting fat-soluble components, the dregs still contain flavonoids, polysaccharides, proteins and other components; , the fat-soluble ingredients are difficult to extract, and the ingredients are easily destroyed by decocting for a long time

Method used

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  • Extraction method of whole components of cassia seeds
  • Extraction method of whole components of cassia seeds
  • Extraction method of whole components of cassia seeds

Examples

Experimental program
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Effect test

Embodiment 1

[0031] A method for extracting the whole components of Semen Cassiae, comprising the following steps:

[0032] a. raw material processing: depending on the dry crushing of cassia medicinal material, passing through a 30-mesh sieve, collecting the sieved powder, and obtaining finely crushed cassia seeds with a water content of 2%;

[0033] b. Supercritical CO 2 Extraction of cassia seed fat oil: 5 kg of finely crushed cassia seed is put into supercritical CO 2 In the extraction device, the gas flow rate is 300m 3 Extraction is carried out under the condition of / h. The extraction device includes an extraction kettle and a separation kettle. The extraction pressure of the extraction kettle is set to 25Mpa, the extraction temperature is 45°C, and the extraction time is 60min. During the process, the supercritical CO 2 Dissolve the oil in the cassia seed, set the separation pressure of the separation kettle to 1 atmosphere, and the separation temperature to 50°C. After the extra...

Embodiment 2

[0036] A method for extracting the whole components of Semen Cassiae, comprising the following steps:

[0037] a. raw material processing: depending on the dry crushing of cassia medicinal material, pass through a 50-mesh sieve, collect the sieved powder, and obtain finely crushed cassia seeds with a water content of 5%;

[0038] b. Supercritical CO 2 Extraction of cassia seed fat oil: 10kg of finely crushed cassia seed is put into supercritical CO 2 In the extraction device, the gas flow rate is 350m 3 Extraction is carried out under the condition of / h. The extraction device includes an extraction kettle and a separation kettle. The extraction pressure of the extraction kettle is set to 35Mpa, the extraction temperature is 55°C, and the extraction time is 120min. During the process, the supercritical CO 2 Dissolve the oil in the cassia seed, set the separation pressure of the separation kettle to 12Mpa, and the separation temperature to 55°C. After the extraction is comple...

Embodiment 3

[0041] A method for extracting the whole components of Semen Cassiae, comprising the following steps:

[0042] a. raw material processing: depending on the dry crushing of cassia medicinal material, passing through a 40-mesh sieve, collecting the sieved powder, and obtaining finely crushed cassia seeds with a water content of 3.7%;

[0043] b. Supercritical CO 2 Extraction of cassia seed fat oil: 7 kg of finely crushed cassia seed is put into supercritical CO 2 In the extraction device, the gas flow rate is 325m 3 Extraction is carried out under the condition of / h. The extraction device includes an extraction kettle and a separation kettle. The extraction pressure of the extraction kettle is set to 30Mpa, the extraction temperature is 50°C, and the extraction time is 90min. During the process, the supercritical CO 2 Dissolve the oil in the cassia seed, set the separation pressure of the separation kettle to 11Mpa, and the separation temperature to 52°C. After the extraction...

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Abstract

The invention provides an extraction method of whole components of cassia seeds and in particular relates to the technical field of traditional Chinese medicine extraction. The extraction method can extract all effective components in cassia seeds and convert the effective components into finished products to the full extent by combination use of two sets of extraction methods including a supercritical CO2 extraction technology and a high-pressure differential low-temperature continuous extraction technology. Added value of products is increased, and the application amount of organic solvent is reduced while the high extraction rate of all effective components is guaranteed, and pollution is reduced. The extraction rate of total flavonoids, polysaccharides, chrysophanol, aurantio-obtusin,cassia glycoside C and cassia glycoside B2 is up to 65% or above, and especially the extraction rate of components which are high content but sensitive to temperature in raw materials as protein and erythromycin and gentiobiose glycoside is up to 65% or above, and extraction steps are simplified so that production cost is saved. The extraction method is simple to operate and easy to repeat and issuitable for realizing standard industrial production.

Description

【Technical field】 [0001] The invention relates to the technical field of extracting traditional Chinese medicines, in particular to a method for extracting all components of Semen Cassiae. 【Background technique】 [0002] Cassia is a medicinal and edible plant recorded in "Chinese Pharmacopoeia" and "Shen Nong's Herbal Classic". Years of pharmacological research have proved that Semen Cassiae has pharmacological activities such as lowering blood pressure, lowering blood fat, laxative, and improving eyesight, and it is also a good raw material for both medicine and food. In the use of traditional Chinese medicine decoctions, cassia seeds are used directly as raw materials. With the continuous development of Chinese patent medicines and health products, cassia seeds need to be used as medicines, and the method of extracting cassia seeds and the types and contents of active ingredients in the extract are directly It affects the quality of cassia seed extract, thereby affecting ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/482
CPCA61K36/482A61K2236/15A61K2236/333A61K2236/37A61K2236/51A61K2236/53
Inventor 刘常青唐树森宋力飞陈伟棠
Owner 广州泽力医药科技有限公司
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