A kind of Gynostemma pentaphyllum vitamin E buccal tablet and its preparation method

A technology of Gynostemma pentaphyllum and buccal tablets, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, and medical preparations with non-active ingredients, etc., and can solve the problem of the appearance, taste, hardness, and disintegration time limit of buccal tablets that have not been studied in depth. and other problems, to achieve the effect of excellent appearance and reasonable molding process

Active Publication Date: 2021-12-24
JIAYING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the Chinese invention patent 201110221340.3 discloses a buccal tablet using Gynostemma pentaphyllum extract powder as a raw material, it only simply prepared a buccal tablet without in-depth research on the appearance, taste, hardness, and disintegration of the buccal tablet. Performance such as time limit

Method used

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  • A kind of Gynostemma pentaphyllum vitamin E buccal tablet and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The preparation of embodiment 1 Gynostemma pentaphylla dimension E buccal tablet

[0050] Proportion by weight of raw materials: 10 parts of Jiaogulan extract powder; 1 part of vitamin E; 70 parts of mannitol; 3.5 parts of steviol glycosides; 5.5 parts of starch slurry (mass fraction is 11%); 2 parts of magnesium stearate; 8 parts of ethanol share.

[0051] Gynostemma pentaphyllum extract powder is prepared by the following method: take the dried whole herb of Gynostemma pentaphylla, use 10 times the weight of the volume fraction of 95% ethanol to reflux extract 3 times, extract 45min each time, combine three filtrates, suction filter and concentrate and dry, And grind it into powder to get Gynostemma pentaphyllum extract powder.

[0052] Preparation:

[0053] (1) Gynostemma pentaphyllum extract powder is mixed with mannitol and steviol glycoside;

[0054] (2) Then add vitamin E dissolved in ethanol;

[0055] (3) Add starch slurry to make a soft material, then granu...

Embodiment 2

[0058] The preparation of embodiment 2 Gynostemma pentaphylla dimension E buccal tablet

[0059] Proportion by weight of raw materials: 12 parts of Jiaogulan extract powder; 1 part of vitamin E; 60 parts of mannitol; 5 parts of steviol glycosides; 3 parts of starch slurry (mass fraction is 11%); 1 part of magnesium stearate; share.

[0060] All the other preparation methods are the same as in Example 1.

[0061] After evaluation, the appearance score of Example 2 is 3 points, mouthfeel 2 points, hardness 2 points and disintegration time limit 2 points.

Embodiment 3

[0062] The preparation of embodiment 3 Gynostemma pentaphylla dimension E buccal tablet

[0063] Proportion by weight of raw materials: 10 parts of Jiaogulan extract powder; 5 parts of vitamin E; 50 parts of mannitol; 5 parts of steviol glycosides; 4 parts of starch slurry (mass fraction is 11%); 3 parts of magnesium stearate; 8 parts of ethanol share.

[0064] All the other preparation methods are the same as in Example 1.

[0065] After evaluation, the appearance score of Example 3 is 3 points, the mouthfeel is 2 points, the hardness is 2 points, and the disintegration time limit is 2 points.

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Abstract

The invention relates to the technical field of pharmaceutical preparations, and specifically discloses Gynostemma pentaphyllum vitamin E buccal tablet and a preparation method thereof. The gynostemma vitamin E buccal tablet is prepared by taking gynostemma extract and vitamin E as active ingredients, and then adding auxiliary materials; the auxiliary materials include diluents, flavoring agents, binders and lubricants. The thinner is selected from mannitol, the described corrective agent is selected from stevioside, and the described binding agent is selected from starch slurry. The Gynostemma pentaphylla vitamin E buccal tablet of the present invention has excellent appearance, mouthfeel, hardness, disintegration time limit and other properties; and its molding process is reasonable, stable and feasible, and is suitable for large-scale industrial production.

Description

technical field [0001] The technical field of pharmaceutical preparations of the present invention particularly relates to a Gynostemma pentaphyllum E buccal tablet and a preparation method thereof. Background technique [0002] Gynostemma [Gynostea pentaphyllu (Thunb.) akino] is a plant of the genus Gynostemma cucurbitaceae, also known as small herbal medicine, aescin, public Luoguodi, born on the ground, and rooted everywhere. It was listed as a health care product by the Ministry of Health on March 5, 2003. product list. The main components of Jiaogulan include gypenosides, flavonoids, polysaccharides, amino acids, vitamins, trace elements, etc., among which 201 kinds of saponins have been found. Gypenoside is the main active ingredient of Gynostemma pentaphyllum, and its aglycone part is basically dammarane-type tetracyclic triterpenoids; it is a good antioxidant. oxidation. [0003] Vitamin E (VitainE, VE), also known as tocopherol and anti-infertility vitamin, is on...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K9/20A61K36/424A61K47/36A61K47/26A61K47/12A61P39/06A61K31/355
CPCA61K36/424A61K31/355A61K9/2059A61K9/2018A61K9/2013A61K9/0056A61P39/06A61K2300/00
Inventor梁香钟娜娜吴凌凤程亚涛张声源丘波聂华
OwnerJIAYING UNIV