Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

CircSPECC1 for brain glioma treatment, and usage thereof

A brain glioma, mir-615 technology, applied in the field of circSPECC1 in the treatment of brain glioma, can solve the problem that the function of circRNAs has not been discovered, and achieve far-reaching effects of prevention and treatment

Pending Publication Date: 2020-06-19
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, circRNAs have gradually become a hotspot in the field of RNA and cancer research, but the functions of most circRNAs have not yet been discovered

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • CircSPECC1 for brain glioma treatment, and usage thereof
  • CircSPECC1 for brain glioma treatment, and usage thereof
  • CircSPECC1 for brain glioma treatment, and usage thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0045] This patent provides a variety of parallel schemes, and the different expressions belong to the improved scheme based on the basic scheme or the parallel scheme. Each scheme has its own unique characteristics.

[0046] The role of Circ RAN in the proliferation and metastasis of glioma, providing a new idea for the prevention and treatment of glioma metastasis

[0047] YB-1 (Y-box binding protein-1) is a member of the cold shock protein superfamily, which contains a highly conserved nucleic acid sequence and is a multifunctional protein. YB-1 is involved in a series of DNA / RNA-dependent events, such as DNA repair, mRNA alternative splicing, regulation of mRNA stability and translation, and plays an important role in cell proliferation, differentiation, stress response and transformation of malignant cells biological function. The previous research of the project team found that YB-1 is overexpressed in glioma tissue and plays a key role in the occurrence and drug resis...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the medical field of genes and especially relates to circSPECC1 for brain glioma treatment and a usage thereof. The invention provides the usage of the circSPECC1 for brain glioma treatment in preparation of medicines for brain glioma treatment. The beneficial effects are as follows: the circSPECC1 can realize targeted regulation of expression of genes HIP1 and Caspase 9 through interactions with miR-615 and can play an important role in invasion and proliferation of gliomas, and capabilities of proliferation and invasion of a glioma U251 cell can be effectively suppressed through suppression of the circSPECC1 as found in the project based on a YB-1 gene of a glioma U251 cell. Implementation of the project is of decisive significance to filling up vacancy in gliomabiological treatment and perfecting current glioma comprehensive treatment measures and is also of profound significance to prevention and control of tumors in other tissues and organs.

Description

technical field [0001] The present invention relates to the field of gene medicine, in particular to a circSPECC1 for treating glioma and its application. Background technique [0002] Research status and existing problems of glioma [0003] Gliomas account for 30% of all nervous system tumors, and 80% of these tumors are malignant brain tumors. With the exception of fibrous astrocytoma, the prognosis of patients with glioma is very poor, with a 5-year survival rate after diagnosis of less than 10%, and age at diagnosis and preoperative Karnofsky performance scale score are well-documented predictors of survival. Over the past 30 years, the conventional treatment for glioma has included maximal surgical resection, local radiation therapy, and chemotherapy with temozolomide. Although the median survival time of patients with glioma improved from 6 months to 14.6 months, the tumor still caused the death of the vast majority of patients. Although many studies are currently d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12N15/113A61K31/7088A61P35/00
CPCC12N15/113A61K31/7088A61P35/00C12N2310/10
Inventor 宫惠琳刘婧威兰平张江伟
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com