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Compositions and methods using oleuropein or curcumin for muscle quality and/or muscle mass

A technology of muscle mass and oleuropein, applied in a kind of recovery field, can solve the problem of lack of effective measures to maintain or improve muscle mass, and achieve the effect of improving recovery and promoting reduction

Pending Publication Date: 2020-06-19
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Effective measures to maintain or improve muscle mass are still lacking

Method used

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  • Compositions and methods using oleuropein or curcumin for muscle quality and/or muscle mass
  • Compositions and methods using oleuropein or curcumin for muscle quality and/or muscle mass
  • Compositions and methods using oleuropein or curcumin for muscle quality and/or muscle mass

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0038] Applicants studied muscle mass in adult rats, early sarcopenic rats and sarcopenic rats. figure 1 A decrease in muscle mass with sarcopenia is shown. figure 2 A reduction in muscle fiber cross-sectional area with age and sarcopenia is shown. There is a higher percentage of small fiber area and a lower percentage of large fiber area.

[0039] Accordingly, one aspect of the present disclosure is a composition comprising at least one of oleuropein or curcumin for use in the treatment or prevention of sarcopenia for reducing muscle mass in an individual such as a mammal (e.g. a human) Loss of at least one of mass or muscle mass, for increasing at least one of muscle mass or muscle mass in an individual, such as a mammal (e.g., a human), and / or for improving muscle in an individual, such as a mammal (e.g., a human) Restoration of at least one of muscle mass or muscle mass following atrophy.

[0040] Another aspect of the present disclosure is a method comprising administ...

Embodiment

[0063] The following non-limiting examples provide scientific data to develop and support the concept of administering a composition comprising oleuropein and / or curcumin to treat sarcopenia, prevent sarcopenia in individuals administered the composition , reducing the loss of muscle mass and / or muscle mass, increasing muscle mass and / or muscle mass and / or improving the recovery of muscle mass and / or muscle mass.

[0064] Aged rats are an excellent model for evaluating the effects of nutritional interventions on age-related muscle decline. With this model, it can be observed that, as in humans, there is a decline in muscle mass and muscle function and changes in muscle mass with age. The aim of this study was to determine the effects of curcumin, oleuropein, and rutin on muscle mass and the correlation with muscle mass in aged rats.

[0065] Twenty-month-old rats were divided into four groups and received a complete diet supplemented with curcumin (CUR), oleuropein (OLE), or ...

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Abstract

A composition comprising at least one of oleuropein or curcumin can treat or prevent sarcopenia, reduce a loss of at least one of muscle quality or muscle mass, increase at least one of muscle qualityor muscle mass, and / or improve recovery of at least one of muscle quality or muscle mass after muscle atrophy. The composition can be administered to an individual who is elderly and / or frail.

Description

Background technique [0001] The present disclosure generally relates to compositions and methods for improving or maintaining at least one of muscle mass or muscle mass using at least one of oleuropein or curcumin. More specifically, the present disclosure relates to administering a composition comprising at least one of oleuropein or curcumin to: treat sarcopenia, prevent sarcopenia, or reduce the progression of sarcopenia; reduce muscle mass or increase at least one of muscle mass or muscle mass; and / or improve recovery of at least one of muscle mass or muscle mass following muscle atrophy. [0002] Sarcopenia is defined as a condition characterized by progressive and widespread loss of skeletal muscle mass and function. One of the causes of this decline is a change in the mass (fiber size and number) of the muscle. Contraction timing, strength and fatigue resistance of skeletal muscle are highly dependent on fiber type distribution and the degree of expression of differen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A61K36/9066A61K36/63A61P21/06A61P39/06
CPCA61K36/9066A61K36/63A23V2002/00A23L33/105A61K31/12A61K31/7048A23V2200/316A23V2250/2112A23V2250/2131A61K2300/00A61P21/00A61P21/06A61K31/121
Inventor C·布特里D·布雷勒M·N·奥卡哈达
Owner SOC DES PROD NESTLE SA
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