69 results about "Nutritional Interventions" patented technology

The invention belongs to the field of biotechnology and nutritional medicine, relates to a maternal obesity intervention preparation, and particularly relates to a preparation method of a plant embryo fermentation product and application of the plant embryo fermentation product in blocking of trans-generation delivery metabolic diseases. FWG is prepared through a probiotic fermentation technology, obesity, glucose and lipid metabolism disorder and oxidative stress induced by high-fat diet of a parent body can be remarkably improved, and cross-generation transmission of metabolic diseases is blocked by adjusting composition of intestinal flora of the parent body and offspring and a hypothalamic PI3K-Akt signal channel. The invention reveals that maternal FWG intervention passes through a mechanism that a PI3K-Akt pathway is dominated and multiple pathways are coordinated on the transcriptome level for the first time, the HFD-induced offspring hypothalamus metabolism programming abnormality is reversed, and a new central regulation target is provided for cross-generation metabolic disease prevention. The FWG is a wheat processing byproduct, is free of chemical additives, is suitable for long-term dietary supplement, is a natural and safe nutrition intervention scheme, and is suitable for the field of maternal and infant health.

The invention discloses a fat reduction management consultation platform and an implementation method thereof, and relates to the technical field of fat reduction management, the fat reduction management consultation platform comprises a data collection module, a basic metabolism module, a body fat trend prediction module, a nutrition intervention module and an exercise intervention module; the data collection module is responsible for collecting user basic sign data including body weight and body fat rate; the exercise frequency, the training type and the diet record of the user are dynamically collected; the basic metabolism module calculates the basal metabolic rate BMR (t) according to the body weight and the body fat rate of the user; generating an activity correction factor AF (t) at each moment according to the heart rate frequency and the training type; a historical calorie intake and body fat change sequence is constructed through the body fat trend prediction module, an XGBoost model is called to predict future body fat change, a final body fat prediction value is output in combination with an error weighted fusion mechanism, whether the user enters a stable period or a fat reduction rebound trend is judged, the body fat change trend of the user is effectively monitored, and the user experience is improved. And the user is effectively helped to know the fat reduction process.

The present invention relates to a precise lactation feed for lactating sows, and 100 kg of the feed product comprises the following raw materials by weight: 20 to 28 kg of soybean meal, 2 to 5 kg of fish meal, 2 to 5 kg of MCT microcapsules, 0.2 to 0.4 kg of rumen protected methionine, 0.1 to 0.2 kg of rumen protected tryptophan, 1.5 to 2.5 kg of inulin, 1 to 2 kg of sodium lignin sulfonate, 0.01 to 0.03 kg of a fenugreek seed extract, 1.2 to 1.8 kg of sn-2 palmitate, 0.4 to 0.6 kg of alpha-ketoglutaric acid, 0.08 to 0.12 kg of glycine iron, and the balance of water. The feed is prepared from the following raw materials by weight: 0.15-0.25 kg of zinc methionine, 4-8 kg of wheat bran, 1.2-1.8 kg of a calcium propionate solution, 2-3 kg of lactic acid bacteria fermentation liquor, 0.2-0.4 kg of a rosemary extract and the balance of corn, wherein the total weight of the raw materials is 100 kg. The feed is a precise nutrition regulation feed formula for the sows in the lactation period, and milk yield increase, piglet weaning performance optimization and sow body condition protection are achieved through multi-dimensional nutrition intervention.

The invention provides a pulmonary nodule targeting food and medicine homologous composition based on metabonomics screening and application thereof. By analyzing a pulmonary nodule specific metabolic profile, active components, namely platycodin D, mogroside V, oyster active peptide and fermented cordycepin, which can cooperatively regulate and control an arachidonic acid inflammation pathway, a glutathione antioxidant pathway and a tricarboxylic acid cycle energy pathway are reversely screened out. Animal experiments prove that the composition can reduce the volume of pulmonary nodules by 58.3%, human body application shows that the nodules of 76.7% of subjects are reduced, and liver and kidney toxicity is avoided. The composition can be prepared into tablets, capsules and other dosage forms, can be used as functional food or adjuvant therapy drugs for high risk groups of pulmonary nodules, and realizes accurate nutrition intervention.

Methods of identifying a canine subject susceptible to inflammatory bowel disease, methods of treating or preventing inflammatory bowel disease in a canine subject, and compositions useful for treating or preventing inflammatory bowel disease in a canine subject are described herein.

The invention belongs to the technical field of cosmetics, and discloses an avocado fermentation composition as well as a preparation method and application thereof. The composition comprises 1%-10% of avocado fermentation filtrate, 0.1%-2% of alpha-glucan oligosaccharide, 0.1%-2% of a wild chrysanthemum flower extract, 3%-8% of a humectant, 0.01%-0.1% of a chelating agent and the balance of deionized water. Wherein the avocado fermentation filtrate is prepared by compound fermentation of aphid torulopsis and candida and is rich in oligopeptide, free amino acid, lactic acid and polyphenol. According to the invention, the filtrate obtained by fermenting avocado with a specific composite strain is scientifically compounded with prebiotics with definite flora selectivity to construct a multifunctional composition with definite structure, synergistic function and high stability; the composition not only provides direct barrier repairing and moisturizing effects, but also actively guides skin micro-ecology to succession to a healthy steady state through nutrition intervention, so that the skin health level is synchronously improved in the two dimensions of molecules and ecology.

The application discloses application of pyrroloquinoline quinone (PQQ) or a derivative thereof in preparation of a product for relieving or preventing blue-green algae toxin poisoning of yellow catfish, and belongs to the technical field of aquatic animal feed. The PQQ or the derivative thereof can be used as an aquatic feed additive or a medicine, and is added in an amount of 3-6 mg / kg of feed to feed yellow catfish, so as to effectively relieve pathological damage of the liver of the yellow catfish caused by blue-green algae toxin through various ways such as improving key enzyme activity of liver function, inhibiting liver oxidative stress, relieving inflammatory reaction and reducing structural damage of tissues. The PQQ is a new food raw material approved in China in 2022, has advantages of high safety, good water solubility, moderate cost, similar dosage to that of feed vitamins and the like, and provides a safe, economical and convenient new nutritional intervention strategy for blue-green algae toxin poisoning of the yellow catfish, and has a wide industrial application prospect.

The invention discloses application of a fucoidin degradation product Fuc-S in a pharmaceutical composition for preventing, relieving or treating type 2 diabetes mellitus and liver injury, and relates to the technical field of biological medicines. The invention provides a new effect of fucoidin Fuc-S in treating diabetic liver injury, and particularly, the fucoidin Fuc-S can significantly improve blood glucose control (reducing fasting blood glucose and enhancing sugar tolerance) and blood lipid spectrum (reducing TG, TC and LDL-C and increasing HDL-C) of diabetic mice, alleviate liver fatty degeneration and reduce serum ALT / AST level, and shows a significant liver protection effect. Furthermore, the Fuc-S can be used for remodeling the intestinal flora structure through specific enrichment of beneficial bacteria such as Bacteroides acdifaciens and the like, so that the generation of short-chain fatty acid (SCFAs) with a liver protection effect is promoted. The flora and metabolic change jointly improve the oxidative stress state of the liver, inhibit pro-inflammatory response and reduce lipid accumulation. The invention provides a novel nutrition intervention strategy for prevention and treatment of T2DM and liver complications thereof.

The application discloses a suspension for improving DON-caused piglet intestinal toxicity and a preparation method and application thereof, and belongs to the technical field of feed additives, and comprises the following raw materials: hesperidin 40-60 mg / mL, sodium butyrate 50-150 mg / mL and PR-39 antibacterial peptide 10-15 mg / mL. The suspension provided by the application can also regulate intestinal flora balance, promote the proliferation of beneficial bacteria such as lactobacillus, and inhibit the growth of harmful bacteria. The effect of the suspension provided by the application is significantly better than that of single component or partial combination, and the suspension provides an efficient and safe nutritional intervention strategy for preventing and treating animal body damage caused by feed mycotoxin pollution.

This invention relates to a precision nutrition decision-making system and method based on offline reinforcement learning, belonging to the field of medical informatics. The method collects and preprocesses patient medical record data, defining patient nutritional status indicators, nutritional intervention plans, and nutritional status benefits after intervention as the state space, action space, and reward function, respectively. Subsequently, an offline reinforcement learning algorithm is used to build a model, enabling the agent to learn to select the optimal nutritional intervention strategy under different nutritional conditions. Finally, the model performance is evaluated on a test dataset, and the impact of different intervention plans on patient nutritional status is compared. This invention can effectively improve the nutritional intervention effect for hospitalized patients and promote the rational allocation of medical resources, possessing high application value.

The invention belongs to the technical field of biological medicines and bioactive peptides, and relates to a xanthine oxidase inhibitory peptide derived from goat milk protein and application thereof. The amino acid sequence of the xanthine oxidase inhibitory peptide is as shown in SEQ ID NO. 1. The xanthine oxidase inhibitory peptide can be used for preparing a product for inhibiting xanthine oxidase or a product for regulating and controlling the uric acid level in a human body. The XOD regulation active peptide provided by the invention is safe in source and clear in structure, can be applied to the field of functional food or nutrition intervention, and provides a safe and natural active substance basis for diet regulation of hyperuricemia and related metabolic diseases.

This invention relates to the field of knowledge graph technology, specifically disclosing a knowledge graph-based system for predicting gut microbiota colonization effects and recommending nutrients. The system includes: knowledge graph construction, data acquisition, microbiota game modeling, dynamic competitive evolutionary reasoning, Nash equilibrium calculation, colonization probability prediction, and a strategic nutrient recommendation output device. It identifies microbiota interactions by constructing a heterogeneous semantic network, describes the strategic change paths of the microbiota under resource conditions using evolutionary game theory algorithms, and identifies the system's stable state and risks by combining Nash equilibrium points. By introducing a dynamic competitive network based on evolutionary game theory, this invention can accurately predict the outcome of microbiota competition, avoid resource competition risks, guide the gut towards a stable state dominated by beneficial bacteria, and improve the accuracy, safety, and regulatory effect of nutritional intervention.

The invention relates to the technical field of aquaculture, and particularly discloses an ecological breeding method for hippocampus. According to the method, a south-north relay breeding mode is adopted, and the key point is that before each time of cross-regional transfer, to-be-transferred hippocampus is subjected to sequential pretreatment including immune preparation stage feeding and acute buffer stage feeding which are performed in sequence. Baits containing chitosan oligosaccharide and fucoidin are used in the immune preparation stage, and baits containing taurine and betaine are used in the acute buffer stage. The transfer is carried out when the water temperature difference is less than or equal to 3 DEG C, and after the hippocampus arrives, the hippocampus is adapted to the new water temperature at the rate gradient of 0.8-1.2 DEG C / h. According to the method, through sequential nutrition intervention and refined environment control, the anti-stress ability of the hippocampus is systematically enhanced, the industrial problems of low survival rate and slow recovery of cross-regional transfer are effectively solved, and efficient and low-cost ecological breeding of the hippocampus is achieved.

The invention discloses a nutrition intervention system and method for tumor chemoradiotherapy patients. The system comprises a molecular nutrition fingerprint acquisition module, a space-time prediction modeling module, a drug-nutrition collaborative optimization module, an intestinal flora-host metabolism modeling module and an active nutrition intervention execution module. By integrating gene polymorphism, intestinal flora and metabonomics data, an individualized molecular nutrition fingerprint is constructed, a deep learning algorithm is adopted to predict the change trend of a nutrition state, a molecular docking technology is adopted to optimize a drug-nutrition synergistic effect, a flora-host metabolism model is established to predict nutrient absorption efficiency, and the nutrient absorption efficiency is improved. And precise active nutrition intervention is realized. The technical problems that in the prior art, nutrition intervention is low in accuracy, preventive intervention cannot be achieved, and medicine-nutrition interaction is neglected are solved, and individualized nutrition management based on the molecular level is achieved.

The present application relates to the field of animal nutrition and microbiology, and in particular to a nutrition intervention method for regulating eggshell mineralization by egg chicken intestinal flora-metabolites, a preparation, a sustained-release granule and an application thereof, comprising the following steps: A. intestinal flora homeostasis establishment period: adding a bile acid precursor complex, a flora regulating complex and an intestinal environment regulator in the feed of 24-week-old laying hens at a proportion of 0.5%, continuously for 14 days; B. metabolite production enhancement period: adding a metabolite precursor complex and a metabolic activity regulator to the feed of laying hens at the peak of egg production at a proportion of 0.8%; C. shell gland mineralization efficiency improvement period: adding a calcium transporter activating complex, a carbonic anhydrase cofactor and an ion channel regulator to the feed of laying hens at the later stage of egg production at a proportion of 1.0%, to promote the production of key metabolites and activate the whole process molecular mechanism of shell gland mineralization.

This invention discloses a hybrid model-driven nutritional risk prediction method and system for precision nutritional intervention. The method constructs a large-scale patient typing model containing multiple typical patient types and their associated assessment parameter packages, integrating a standardized first screening model with a personalized second screening model. In application, the first screening model is first used to standardize and initially screen patient data. Then, the large-scale patient typing model extracts patient feature inputs based on the patient data and initial screening results for typing and obtains the corresponding assessment parameter packages. The second screening model is then personalized based on these parameter packages, supplemented with key data, and combined with personalized thresholds to calculate the final risk level and generate a comprehensive assessment report. This invention achieves dynamic individualized adaptation of assessment strategies, improves the accuracy and clinical interpretability of risk identification, and optimizes workflow and resource allocation.

The application discloses a system for generating a personalized nutritional prescription for sarcopenia and a computer readable storage medium, and relates to the technical field of medical nutritional intervention and health management. The system comprises basic information input, special examination result input, daily nutritional intake output and a nutritional prescription generation module. Based on the patient's basic information, clinical information, gene test report and intestinal microbiome data, the system generates a clinical nutritional benchmark framework, gene-related, flora-related and disease-related nutritional constraint items, and forms a unified constraint set in combination with individual preferences and execution feasibility. The nutritional prescription generation module constructs a food nutritional component matrix and a target function according to the unified constraint set, a list of selected foods and a nutritional supplement specification, solves an optimal food consumption vector under the conditions of meeting hard constraints and soft constraints, generates a daily food intake list, a per-meal food list and a nutritional supplement scheme, and improves the individualization, medical consistency and clinical executability of the nutritional prescription.

The invention discloses a nutrition intervention composition with functions of regulating liver metabolism, promoting liver repair and resisting hepatic fibrosis. The nutrition intervention composition comprises purple perilla micro-capsule powder, a protein component, a liver peptide component, glutathione-rich yeast, a silybum marianum component, corn oligopeptide powder, oat powder and a fermentation product of germinated brown rice powder. According to the nutrition intervention composition disclosed by the invention, the microencapsulated perilla frutescens extract is organically integrated with antioxidant, regeneration-promoting and metabolism-regulating components such as a protein component, a liver peptide component, glutathione-rich yeast, a silybum marianum component and corn oligopeptide, so that the stability and bioavailability of fat-soluble active components are improved; the functions of exogenous anti-oxidation, endogenous anti-oxidation supplement, hepatocyte repair and intestinal-hepatic axis regulation are synergistically enhanced, so that the synergistic and lasting liver protection, repair and anti-fibrosis effects are realized.

This invention belongs to the field of food nutrition and functional factors, specifically relating to a method for preparing highly immunomodulatory ovotransferrin (OVT) hydrolysates based on an adult gastrointestinal simulated digestive system. The method involves processing OVT using a simulated adult gastrointestinal tract to prepare OVT hydrolysates containing HTEGSTT, TTSY, and / or RTAGWVIPMG. This invention reveals that OVT exhibits enhanced immunomodulatory activity after gastrointestinal digestion and hydrolysis, and is more readily hydrolyzed in simulated adult digestive fluids than in infant digestive fluids. Comparative experiments show that nutritional intervention with OVT simulated digestive products from adults and infants can promote the production of short-chain fatty acids such as acetic acid, propionic acid, and butyric acid, effectively alleviate swelling and damage to the small intestinal mucosa caused by inflammation, significantly improve intestinal barrier immune function, and OVT IA exhibits higher intestinal immune activity than OVT IB.

This invention discloses a food-medicine formula and preparation process for regulating a constitution with mixed qi deficiency and phlegm-dampness, relating to the field of food preparation technology. The food-medicine formula and preparation process for regulating a constitution with mixed qi deficiency and phlegm-dampness includes Astragalus membranaceus, Codonopsis pilosula, stir-fried white hyacinth bean, stir-fried coix seed, yam, Poria cocos, hawthorn, stir-fried malt, Alpinia oxyphylla, lotus seed, Euryale ferox, lotus leaf, tangerine peel, Amomum villosum, and Citrus medica. This invention uses Shenling Baizhu Powder as its base formula, removing licorice and platycodon, and adding astragalus, tangerine peel, etc., to achieve "stronger qi replenishment, smoother qi circulation, more effective digestion, and better metabolism." The formula has a clear layering, adding tangerine peel and other ingredients to regulate qi, eliminate stagnation, promote the upward movement of clear qi and the downward movement of turbid qi, and harmonize the stomach, while avoiding "stagnation and dampness promotion." It also adheres to the principle of "replenishing without stagnation and eliminating without harm." It precisely targets the complex constitution of modern people with "spleen deficiency + phlegm dampness + metabolic disorder," and introduces resistant dextrin, reflecting the trend of integrating "traditional formulas + modern nutritional intervention."

The invention discloses a carbon tetrachloride damage model construction and nutrition intervention evaluation method based on a three-dimensional liver chip, and belongs to the technical field of microfluidics and biological medicines. According to the method, an in-vitro bionic liver tissue model is constructed by utilizing a three-dimensional liver chip, liver cell injury is induced by perfusing carbon tetrachloride, on the basis, substances such as algae-derived extracellular vesicles are added for repairing intervention, and meanwhile, contrastive analysis is performed with a two-dimensional plate culture system. Results show that the secretion level and the function maintenance time of albumin, urea and the like of liver cells in a liver chip model are superior to those of two-dimensional culture, and after nutrient intervention is carried out, liver injury indexes such as ALT, AST and the like in the chip model are remarkably reduced, and the cell activity and the metabolic function are obviously recovered. The model can be used for evaluating the curative effect of nutrient substances on chemical liver injury, overcomes animal experiment species difference and two-dimensional culture limitation, provides an efficient and sensitive in-vitro research platform for medicine and nutrition function screening, and has wide application prospects and industrialization potential.

This invention provides the application of a nutritional composition in the preparation of products that promote neural development and support the improvement of neural function. The research of this invention found that intervention in the body using a nutritional composition comprising *Bifidobacterium animalis* subsp. *lactobacterium* CP-9 and 3'-sialic acid lactose can promote the development of amygdala neuronal structure, improve neural plasticity, and enhance synaptic function, thereby promoting the formation and functional maturation of the normal amygdala structure. As a core brain region regulating emotional responses, social cognition, and stress responses, the normal development of the amygdala plays a crucial role in an individual's emotional regulation ability, social interaction behavior, cognitive function, and mental health. Therefore, this invention promotes the structural and functional development of the amygdala through nutritional intervention, ultimately improving an individual's emotional regulation ability, social interaction behavior, cognitive function, and mental health.

1. Name of the product in this design: Graphical User Interface for Displaying Human Body Monitoring Reports in Electronic Equipment. 2. Purpose of this design: An electronic device. 3. The key design features of this product are the graphical user interface portion of the electronic device for which protection is sought. 4. The picture or photo that best illustrates the key design points: Design 1 front view. 5. The electronic devices in Designs 1-4 are conventional designs, and other views of Designs 1-4 are omitted. 6. Design 1 is designated as the basic design. 7. Purpose of the Graphical User Interface: The product interfaces in Designs 1-4 serve as the display and interactive interface for human body monitoring reports; they are used to display basic user information, nutritional imbalance risks, health risk warnings, nutritional vitality tips, dietary recommendations, monitoring requirements, and precautions, etc. In the main view interface of Design 1, swiping up to the bottom displays all monitoring report information, sequentially showing interface change state diagrams 1-2; in interface change state diagram 2, clicking the "View Nutritional Intervention Plan" button displays interface change state diagram 3; in the main view interface of Design 2, clicking the "Increased Risk of Allergic Constitution" button displays interface change state diagram 1; swiping up from interface change state diagram 1 to the bottom displays interface change state diagram 2; in the main view interface of Design 3, swiping up displays interface change state diagram 1; in interface change state diagram 1, clicking the "Vitamin A" button displays interface change state diagram 2; swiping up from interface change state diagram 2 to the bottom displays interface change state diagram 3; in the main view interface of Design 4, swiping up displays interface change state diagram 1; in interface change state diagram 1, clicking the "View Comprehensive Health Information" button displays interface change state diagram 2.

This application discloses a method and apparatus for generating nutritional plans based on knowledge graphs. The method first obtains the gut microbiota detection results of the target object, extracts the abundance information of each bacterial species, and maps it to bacterial species nodes in the knowledge graph. Then, it calculates the functional coverage value of each metabolic function based on the functional contribution relationship between bacterial species and metabolic functions, and constructs functional redundancy characterization parameters based on the synergistic effect between multiple bacterial species pointing to the same metabolic function node. Next, it identifies target metabolic function gaps where both functional coverage and functional redundancy are insufficient, and determines the corresponding set of candidate nutritional factors. Finally, it combines food association relationships with the target object's gut microbiota adaptation characteristics to screen target food combinations and generate personalized nutritional plans. This invention can accurately identify key gaps in the overall metabolic function of the gut microbiota, avoids the limitations of single-species abundance analysis, and significantly improves the targeting and accuracy of nutritional interventions.

The invention discloses a nano iron oxide and colla corii asini synergistic blood replenishing nutrition formula and a preparation method thereof. The formula comprises the following components: 0.5-3% of surface functionalized nano iron oxide, 0.5-3% of colla corii asini and the balance of water. 30-50% of a donkey-hide gelatin matrix; 0.5 to 2.5% of vitamin C or a vitamin C derivative; 2-7% of plant polysaccharide; 0.5-3% of a licorice extract; 40-55% of ice syrup; the preparation method comprises the following steps: dissolving the donkey-hide gelatin matrix, adding the premixed nano iron oxide and vitamin C derivative, carrying out ultrasonic dispersion, sequentially adding other components, and carrying out homogenization treatment. According to the invention, sodium citrate or gelatin-coated nano iron oxide is used as a high-efficiency iron source and is matched with the blood replenishing effect of donkey-hide gelatin to realize function synergy; the bioavailability of iron is remarkably improved through the compatibility of vitamin C and polysaccharide; the nutritional powder has the advantages of traditional nourishing and modern nutritional supplement, and can be prepared into various dosage forms such as paste and soft sweets. In addition, the in-vitro absorption rate is 1.8-2.5 times of that of a traditional iron agent, the gastrointestinal irritation is remarkably reduced, and the iron-containing compound preparation is particularly suitable for nutrition intervention of people suffering from iron-deficiency anemia.

This invention discloses the application of *Bifidobacterium animalis* subsp. *lactamase* GOLDGUT-BB21 in lowering uric acid, belonging to the field of biomedical technology. This strain is deposited at the China General Microbiological Culture Collection Center (CGMCC) with accession number CGMCC No. 29347, on December 18, 2023, and is taxonomically named *Bifidobacterium animalis* subsp. *lactamase*. Bifidobacterium animalis subsp.lactis The present invention, Bifidobacterium lactis subspecies GOLDGUT-BB21, exhibits outstanding effects in lowering uric acid, improving renal function, regulating intestinal flora, and enhancing the intestinal barrier. It is safe, mild, and has multi-target synergistic characteristics, and can provide a highly efficient and promising microecological solution for nutritional intervention in hyperuricemia and related metabolic abnormalities.

The application discloses an enteral nutritional composition, comprising an enteral nutritional suspension and inulin. In a mouse colon anastomosis model, 2 mg / kg of lipopolysaccharide (LPS) is injected intraperitoneally 24 hours before the operation to establish a systemic inflammation preconditioning background, and enteral nutritional intervention containing inulin is given after the operation. The experimental results show that, compared with the enteral nutritional suspension without the addition of inulin, the enteral nutritional composition containing inulin can improve postoperative recovery, improve the mechanical strength of the anastomotic stoma, reduce local inflammation cell infiltration of the anastomotic stoma, enhance local tissue proliferation activity and reduce cell apoptosis, promote the macrophage phenotype to deviate to the repair direction, and be accompanied by adjustment of tissue adhesion bacterial community structure and increase of butyric acid level. The application provides a clear composition and implementable technical solution for early postoperative nutritional support under the background of high risk of inflammation.

The application belongs to the technical field of cosmetics, and discloses an avocado fermentation composition and a preparation method and application thereof. The composition comprises 1%-10% of avocado fermentation filtrate, 0.1%-2% of alpha-glucan oligosaccharide, 0.1%-2% of wild chrysanthemum extract, 3%-8% of a humectant, 0.01%-0.1% of a chelating agent, and the rest of deionized water. The avocado fermentation filtrate is obtained by complex fermentation of aphid pseudomycetes and candida fungi, and is rich in oligopeptides, free amino acids, lactic acid and polyphenols. The application scientifically compounds the filtrate obtained by fermenting avocados with specific complex strains and prebiotics with clear bacterial flora selectivity, and constructs a multifunctional composition with clear structure, synergistic function and high stability. The composition not only provides direct barrier repair and moisturizing effect, but also actively guides the skin micro-ecosystem to healthy succession through nutritional intervention, thereby synchronously improving the skin health level in two dimensions of molecules and ecology.

The invention relates to the technical field of intelligent medical assistance, in particular to a clinical nutrition detection multi-source data integration processing and auxiliary management system which comprises a standardized evaluation and feature extraction module, a disease specific rule adaptation module and a multi-target collaborative intervention generation module. The method comprises the following steps of: converting multi-source heterogeneous data into structured nutrition quantitative characteristics by constructing a hierarchical evaluation dimension system; calling an evidence-based disease nutrition protocol library to generate accurate intervention guidance; the emotion state and nutrition-emotion associated knowledge of the patient are fused, and a physiological-psychological collaborative individualized nutrition intervention scheme is output through multi-layer screening and dynamic sorting, so that the problem of insufficient suitability and compliance in the prior art is solved.

This invention relates to nutritional compositions comprising at least one fucosylated oligosaccharide, preferably 2FL, for use in enhancing pancreatic development and / or pancreatic maturation in infants, and / or improving insulin biosynthesis, and / or preventing metabolic disorders or associated diseases, and / or managing glucose during nutritional intervention or later in life. The composition may be an infant formula. The composition may also comprise at least one N-acetylated oligosaccharide, preferably LnNT.