The invention discloses a tube feeding clinical nourishment with a blood fat reducing effect. The tube feeding clinical nourishment comprises the following raw materials in parts by weight: 2,000 to 4,000 parts of puffed powder, 500 to 2,000 parts of soybean separation protein, 1,000 to 3,000 parts of maltodextrin, 1,000 to 2,000 parts of milk powder, 500 to 2,000 parts of resistant starch, 100 to 500 parts of black rice bran, 200 to 500 parts of inulin, 200 to 500 parts of polydextrose, 100 to 200 parts of sea bass blood fat-reducing active peptide and 7 to 14 parts of taurine. The invention also discloses a preparation method for the tube feeding clinical nourishment with the blood fat reducing effect. The tube feeding clinical nourishment meets the requirement on tube feeding food, has a blood fat reducing effect, can be used for performing nutritional intervention on severe hyperlipidemia patients; the tube feeding clinical nourishment is rich in nutrition, natural and safe.