Applications of cyanidin-3-O-glucoside in preparation of medicines treating diseases caused by 3-chloropropane-1,2-diol

A technology of glucoside and cyanidin, applied in the field of biomedicine, can solve problems such as no reported protective effect, and achieve the effects of reducing damage to spermatogenic epithelium, improving spermatogenic disorders, and maintaining stability

Inactive Publication Date: 2017-12-19
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report on the protective effect of anthocyanins on 3-MCPD reproductive damage in the current study. This study hopes to provide a theoretical basis for future nutritional intervention of anthocyanins on 3-MCPD reproductive toxicity

Method used

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  • Applications of cyanidin-3-O-glucoside in preparation of medicines treating diseases caused by 3-chloropropane-1,2-diol
  • Applications of cyanidin-3-O-glucoside in preparation of medicines treating diseases caused by 3-chloropropane-1,2-diol
  • Applications of cyanidin-3-O-glucoside in preparation of medicines treating diseases caused by 3-chloropropane-1,2-diol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Test material:

[0044] 1.1 Experimental animals

[0045] Fifty-four 10-week-old male Wistar rats were purchased from Guangdong Experimental Animal Center. Rats were raised in the SPF grade animal room of Jinan University School of Medicine, with 12-hour alternation of day and night. The temperature was maintained at 22°C-26°C, the relative humidity was 60%-80%, and they were free to eat.

[0046] 1.2 Animal feed and reagents

[0047] Ordinary AIN93-G feed was purchased from Jiangsu Medison, and AIN93-G feed added with C3G was purchased from Jiangsu Medison. The formula of AIN93-G feed added with C3G is shown in Table 1:

[0048] Table 1 adds the AIN93-G feed formula of C3G

[0049]

[0050] The feed is entrusted to be processed by Jiangsu Medisen Biomedical Co., Ltd.

[0051] 1.3 Preparation of 3-MCPD solution

[0052] Accurately weigh 5g of 3-MCPD, dissolve in 500mL of normal saline, stir well, and store at 4°C. Reconstitute once a week.

[0053] 2. Expe...

Embodiment 2

[0253] Embodiment 2: result and analysis:

[0254] 1. Behavior during animal feeding

[0255] During the administration period, the rats in the control group were in a good growth state and energetic, the rats in the administration group were depressed, and the rats in the C3G intervention groups with various doses were in a good mental state and energetic. The food intake of each group decreased slightly within two weeks of administration, and the food intake was stable after the second week. At the same time, the water intake of each group decreased during the administration period. Rats in each group did not die during the administration period. In addition, due to other external factors such as serum hemolysis and sperm determination errors during the treatment of rats, individual data were abnormal, so they were excluded and ≥6 rats in each group were retained.

[0256] 2. Changes in body weight and food intake of rats

[0257] 2.1 Changes in body weight of rats

[02...

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Abstract

Applications of cyanidin-3-O-glucoside in preparation of medicines treating and / or preventing diseases caused by 3-chloropropane-1,2-diol are provided. The cyanidin-3-O-glucoside (C3G) can improve rat ingestion decrease and growth retardation which are caused by 3-MCPD poisoning, can effectively resist rat antioxidant system damage caused by 3-MCPD poisoning, and can activate and adjust BTB structural functions of sustentacular cells through inhibiting an MAPK signaling pathway, thus relieving seminiferous epithelium injuries caused by the 3-MCPD, maintaining stability of a spermatogenic microenvironment, regulating spermatogenic cell proliferation and differentiation, and improving dyszoospermia. In addition, the C3G can improve sperm activity through adjusting sperm energy metabolism related enzymes. The C3G can regulate rat sex hormone secretion disorders caused by 3-MCPD poisoning and can maintain normal levels of sex hormone in serum and androgen in testis inner environments. The applications provide theoretical foundations for 3-MCPD reproduction toxicity nutritional intervention utilizing anthocyanin.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and more specifically, relates to cyanidin-3-O-glucoside in the preparation and / or prevention of 3-chloro-1,2-propanediol or 3-chloro-1,2-propanediol ester The application of drugs induced by reproductive diseases. Background technique [0002] 3-Chloro-1,2-propanediol (3-MCPD) is widely present in food and is highly toxic. The metabolite of 3-chloro-1,2-propanediol ester widely present in oil is 3-chloro- 1,2-propanediol and 3-MCPD are easily absorbed in the digestive tract, widely distributed in body fluids, and can cross the blood-testis barrier and blood-brain barrier to reach the testis and brain. Pharmacokinetics show that: 3-MCPD can be widely distributed throughout the body after being absorbed through the gastrointestinal tract, and most of the chloropropanol in the blood can be metabolized after 24 hours, but the accumulation in the brain can reach 20%. It is as high as 60% in the...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P15/00A61P15/08
CPCA61K31/7048A61P15/00A61P15/08A23K20/163
Inventor 白卫滨朱翠娟孙建霞蒋鑫炜李旭升李夏焦睿
Owner JINAN UNIVERSITY
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