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Use of cyanobacterial biomass in treating hepatitis b virus infection

A hepatitis virus and biomass technology, applied in antiviral agents, medical preparations containing active ingredients, food science, etc., can solve problems such as inability to clear infection

Pending Publication Date: 2020-06-30
FAR EAST BIO TEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs only stop or reduce viral replication, and none of them can clear the infection

Method used

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  • Use of cyanobacterial biomass in treating hepatitis b virus infection
  • Use of cyanobacterial biomass in treating hepatitis b virus infection
  • Use of cyanobacterial biomass in treating hepatitis b virus infection

Examples

Experimental program
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experiment example

[0065]

[0066]

[0067] Chromosomal DNA of the FEM102 strain was extracted. After amplification by polymerase chain reaction (PCR), the 16S-23S rDNA sequence was analyzed by ABI 3730 DNA analyzer and ABI BigDye V3.1 software. The analysis results showed that the 16S-23S ribosomal RNA (rRNA) gene of the FEM102 strain contained the nucleotide sequence shown in SEQ ID NO: 1. Using the online nucleotide BLAST database query provided by the National Center for Biotechnology Information (NCBI), it was found that this sequence is highly conserved among various Arthrospira species, including Arthrospira maxima (also known as Arthrospira Spirulina maxima), Spirulina platensis (also known as Spirulina platensis), Spirulina Ordos (A.erdosensis), Spirulina fusiformis (A.fusiformis), Spirulina indica (A.indica) ) and A. terebriformis.

[0068]

[0069] The preparation method of dry FEM102 powder is as follows. First, the FEM-102 strain (stock for culture: 350 L; O.D.0.2) was cult...

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Abstract

Disclosed herein is the use a cyanobacterial biomass for treating hepatitis B virus (HBV) infection, in particular, chronic HBV infection. According to various embodiments of the present disclosure, the cyanobacterial biomass, upon administration of at least one month, significantly reduces the level of the surface antigen of hepatitis B virus (HBsAg) detectable in the subject receiving the treatment and / or mitigates insomnia associated with chronic HBV infection.

Description

[0001] Cross-reference to related applications [0002] The present disclosure is related to, and claims priority to, US Provisional Patent Application No. 62 / 587,488, filed November 17, 2017, which is hereby incorporated by reference in its entirety. technical field [0003] The present disclosure generally relates to the treatment of hepatitis B virus (HBV) infection. Specifically, the present disclosure relates to the use of blue-green algal biomass for the treatment of HBV infection. Background technique [0004] HBV is a small bivalve virus belonging to the Hepatoviridae family. HBV can cause acute and chronic infections. Acute HBV infection is associated with acute viral hepatitis. Typical symptoms of this disease before jaundice include: malaise, nausea, vomiting, headache, fever, skin rash, arthralgia, arthritis, and / or dark urine. In most patients, the disease may persist for several weeks and gradually improve, however, approximately 1% to 2% of patients with ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/748A61K31/7052A23L33/105A61P1/16A61P31/20
CPCA61K31/522A61K31/675A61K31/7072A61K35/748A23L33/135A61K36/748A61K38/212A61K2300/00A61K45/06A61P31/20A61P43/00A61P1/16A61K9/2095
Inventor 阙壮群陈亦翔吴明顺阙俊玮
Owner FAR EAST BIO TEC
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