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Composition capable of improving water solubility of curcumin and application of composition in preparation of compound for treating Alzheimer diseases

A technology of curcumin and composition, applied in the application of compound prescriptions, improving the field of curcumin water-soluble compositions, can solve the problems of instability, poor water-solubility of curcumin, unsatisfactory activity, etc., and achieve significant curative effect

Pending Publication Date: 2020-07-10
湖南中茂生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, curcumin has poor water solubility, low oral bioavailability, unsatisfactory activity and instability, resulting in poor curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The present embodiment provides a kind of compound that curcumin and α-GPC mix and prepare treatment AD, by weight, comprise following composition:

[0039] Composition (including 25kg konjac polysaccharide, 25kg stevioside and 17.5kg hydroxyethyl cellulose) 35kg, curcumin 35kg, α-GPC 25kg, Polygonum multiflorum polysaccharide 7.5kg, polygala saponin 7.5kg.

[0040] The preparation method of above-mentioned compound specifically comprises the following steps:

[0041] S1, curcumin is dissolved in dehydrated alcohol, the solid-liquid ratio (g / mL) of curcumin and dehydrated alcohol is 1:7.5, obtains curcumin alcohol solution after stirring;

[0042] S2. Dissolving the composition in water so that the mass concentration of the composition is 35%, to obtain a water-soluble dispersion;

[0043] S3, mixing the curcumin alcohol solution of step S1 with the water-soluble dispersion of step S2, the volume ratio of the curcumin alcohol solution and the water-soluble dispersion i...

Embodiment 2

[0047] The present embodiment provides a kind of compound that curcumin and α-GPC mix and prepare treatment AD, by weight, comprise following composition:

[0048] Composition (including 20kg konjac polysaccharide, 20kg stevioside and 15kg hydroxyethyl cellulose) 30kg, curcumin 30kg, α-GPC 20kg, Polygonum multiflorum polysaccharide 5kg, polygala saponin 5kg.

[0049] The preparation method of above-mentioned compound specifically comprises the following steps:

[0050] S1, dissolving curcumin in dehydrated alcohol, the solid-liquid ratio (g / mL) of curcumin and dehydrated alcohol is 1:5, obtain curcumin alcohol solution after stirring;

[0051] S2. Dissolving the composition in water, so that the mass concentration of the composition is 30%, to obtain a water-soluble dispersion;

[0052] S3, mixing the curcumin alcohol solution of step S1 with the water-soluble dispersion of step S2, the volume ratio of the curcumin alcohol solution and the water-soluble dispersion is 1:1, and...

Embodiment 3

[0056] The present embodiment provides a kind of compound that curcumin and α-GPC mix and prepare treatment AD, by weight, comprise following composition:

[0057] Composition (including 30kg konjac polysaccharide, 30kg stevioside and 20kg hydroxyethyl cellulose) 40kg, curcumin 40kg, α-GPC 30kg, Polygonum multiflorum polysaccharide 10kg, polygala saponin 10kg.

[0058] The preparation method of above-mentioned compound specifically comprises the following steps:

[0059] S1, dissolving curcumin in dehydrated alcohol, the solid-liquid ratio (g / mL) of curcumin and dehydrated alcohol is 1:10, obtain curcumin alcohol solution after stirring;

[0060] S2, dissolving the composition in water, so that the mass concentration of the composition is 40%, to obtain a water-soluble dispersion;

[0061] S3, mixing the curcumin alcohol solution of step S1 with the water-soluble dispersion system of step S2, the volume ratio of the curcumin alcohol solution and the water-soluble dispersion s...

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Abstract

The invention relates to the field of biomedicine, in particular to a composition capable of improving water solubility of curcumin and application of the composition in preparation of a compound fortreating Alzheimer diseases (AD). In order to develop an efficient drug for resisting Alzheimer diseases, the invention provides the composition capable of improving the water solubility of curcumin.The composition comprises konjac polysaccharide, stevioside and hydroxyethyl cellulose, the solubility of curcumin in water can be modified effectively through the composition, the water solubility ofcurcumin can be improved, and the bioavailability of curcumin can be increased. At the same time, the compound for treating AD can be prepared through mixing of the composition, curcumin, alpha-GPC,polygonum multiflorum polysaccharide and tenuigenin, it is found through Morris water maze detecting experiments and determination experiments of the content of SOD, AchE and MDA that the purposes ofimprovement of the learning memory function and treatment of Alzheimer diseases can be achieved through improvement of the ability of free radical removal and promotion of release of acetyl choline, and the therapeutic effect is efficient and remarkable.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a composition for improving the water solubility of curcumin and its application in preparing a compound prescription for treating senile dementia. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a degenerative disease of the central nervous system. With the development of society, the prolongation of human life span, the phenomenon of social aging is becoming more and more serious, the prevalence of senile dementia has increased significantly, and it has become one of the main causes of death, and its incidence increases with age. Epidemiological statistics show that the incidence of AD in the elderly over 60 years old can reach 2%-3%. With the aging process of the world population, AD has become one of the four major diseases that seriously threaten the health of the elderly. AD is a comprehensive disease, the main clinical manifestation of ...

Claims

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Application Information

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IPC IPC(8): A61K47/26A61K47/20A61K47/38A61K36/69A61P25/28A61K31/685A61K31/12A61K31/715
CPCA61K47/26A61K47/20A61K47/38A61K31/685A61K31/12A61K31/715A61K36/69A61P25/28A61K2300/00
Inventor 赵勇彪李佳莲危志刚易娜
Owner 湖南中茂生物科技有限公司
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