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Toltrazuril potassium salt soluble powder as well as preparation method and usage thereof

A toltrazuril and soluble technology, which is applied in powder delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the unfavorable production, transportation and use of toltrazuril raw material drugs, and different mixing and administration methods. Convenience, inaccurate dosage and other problems, to achieve the effect of good solubility, small adverse reactions and significant curative effect

Active Publication Date: 2014-04-02
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, toltrazuril is insoluble in water, and it is usually administered in the form of a premix. Due to the particularity of the feeding habits of chickens, the way of administering the mixture is not only inconvenient, but also difficult to mix with the feed, resulting in Inaccurate dosing can lead to serious waste of medicines
Not only that, but the toltrazuril raw material also has the problems of poor stability and strong hygroscopicity, which makes the toltrazuril raw material prone to failure in a short period of time, which is not conducive to the production, transportation and use of toltrazuril raw material

Method used

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  • Toltrazuril potassium salt soluble powder as well as preparation method and usage thereof
  • Toltrazuril potassium salt soluble powder as well as preparation method and usage thereof
  • Toltrazuril potassium salt soluble powder as well as preparation method and usage thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1) Weigh 5.0kg of toltrazuril potassium salt, 0.5kg of anhydrous sodium bicarbonate, 1.0kg of anhydrous sodium carbonate, 0.2kg of anhydrous calcium chloride, 37.4kg of lactose and 55.9kg of mannitol. Sodium hydrogen and anhydrous sodium carbonate are uniformly mixed as a pH regulator, lactose and mannitol are uniformly mixed as a water-soluble diluent, lactose can also be replaced by sucrose and glucose, and mannitol can also be replaced by sorbitol. ;

[0024] 2) Weigh 5.0 kg of water-soluble diluent and tortrazuril potassium salt and mix well to obtain a mixture A of water-soluble diluent and toltrazuril potassium salt;

[0025] 3) Dilute the remaining water-soluble diluent with the doubling dilution method to dilute the anhydrous calcium chloride and the pH regulator once respectively to obtain the mixture B of the water-soluble diluent and anhydrous calcium chloride, the water-soluble diluent and the pH regulator mixture C;

[0026] 4) Add mixture A, mixture B, m...

Embodiment 2

[0028] 1) Weigh 10.0kg of toltrazuril potassium salt, 1.0kg of anhydrous sodium bicarbonate, 2.5kg of anhydrous sodium carbonate, 0.5kg of hydrogenated tallow primary amine, 21.6kg of lactose and 64.4kg of mannitol. Sodium hydrogen and anhydrous sodium carbonate are uniformly mixed as a pH regulator, and lactose and mannitol are uniformly mixed as a water-soluble diluent;

[0029] 2) Weigh 10.0 kg of water-soluble diluent and tortrazuril potassium salt and mix well to obtain a mixture A of water-soluble diluent and toltrazuril potassium salt;

[0030] 3) Dilute the remaining water-soluble diluent with the double dilution method to dilute the hydrogenated tallow primary amine and the pH regulator once, respectively to obtain the mixture B of the water-soluble diluent and the hydrogenated tallow primary amine, the water-soluble diluent and the pH regulator mixture C;

[0031] 4) Add mixture A, mixture B, mixture C and the remaining water-soluble diluent after dilution in step 3...

Embodiment 3

[0033] 1) Weigh 20.0kg of toltrazuril potassium salt, 1.5kg of anhydrous sodium bisulfite, 4.0kg of anhydrous sodium sulfite, 0.8kg of ammonium chloride and 73.7kg of glucose, first mix anhydrous sodium bisulfite and anhydrous sodium sulfite Mix well as a pH regulator, glucose can also be replaced by lactose;

[0034] 2) Weigh 20.0 kg of anhydrous glucose and toltrazuril potassium salt and mix well to obtain a mixture A of anhydrous glucose and toltrazuril potassium salt;

[0035] 3) Dilute the remaining glucose with ammonium chloride and pH regulator once each by the doubling dilution method to obtain mixture B of glucose and ammonium chloride and mixture C of glucose and pH regulator;

[0036] 4) Add mixture A, mixture B, mixture C and the remaining anhydrous glucose diluted in step 3) into the three-dimensional mixer, start the mixer, and mix thoroughly for 45 minutes to obtain toltrazuril potassium salt soluble powder.

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Abstract

The invention discloses a toltrazuril potassium salt soluble powder and a preparation method thereof. The toltrazuril potassium salt soluble powder is prepared from the following raw materials by mass percent: 2.5-50% of toltrazuril potassium salt, 1-20% of a pH regulator, 0.1-3% of an anti-caking agent and 27-96.4% of a water soluble diluent. According to the method, a solid dispersion technology is adopted, so that the toltrazuril potassium salt can be well dispersed in solid dispersion carrier formed by the water soluble diluent, the pH regulator and the anti-caking agent, and the toltrazuril potassium salt soluble powder can be prepared. The toltrazuril potassium salt soluble powder is soluble in water, high in stability and weak in hygroscopicity. Therefore, the medicine prepared by the soluble powder is soluble in water, high in stability and weak in hygroscopicity, can be used for treating and preventing coccidiosis of animals, and is remarkable in treatment effect and convenient in dosage; furthermore, the dosage of administration can be accurately controlled according to the state of the illness of the animal, so that the coccidiosis of the animals can be rapidly and accurately prevented and treated, and the waste of the medicine in the dosing process can be avoided. The prepared soluble powder is simple in method and low in cost.

Description

technical field [0001] The invention relates to a soluble powder of toltrazuril potassium salt, a preparation method and application thereof, and belongs to the field of veterinary preparations. technical background [0002] Chicken coccidiosis is a chicken parasitic disease caused by Eimeria coccidiosis. Most of them break out in young animals, and the mortality rate is as high as 30%. It is currently the most harmful parasitic disease to the chicken industry. There is no cross-immunity between the various species of Eimeria, and it is easy to break out coccidiosis caused by different species. Rabbit coccidiosis is caused by a variety of coccidia of the genus Eimeria parasitizing in the small intestine or bile duct epithelial cells of rabbits. Rabbits of various breeds and ages can be infected, but rabbits aged 1 to 3 months are the most susceptible and have serious illness and high mortality; A mucohemorrhagic inflammatory disease of the small and large intestines caused...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/53A61K47/26A61K47/18A61K47/10A61K47/04A61P33/02
Inventor 陈清平熊玲玲王铭宏
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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