Contrast agent for abdominal imageology examination

A contrast agent and abdominal technology, applied in the direction of X-ray contrast agent preparation, in vivo test preparations, radioactive carriers, etc., to achieve the effects of reducing absorption, improving safety, and easy application

Pending Publication Date: 2020-07-14
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In order to overcome the current bottleneck of lacking a contrast agent for abdominal imaging examination that can effectively suppress obesity, can be stored for

Method used

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  • Contrast agent for abdominal imageology examination
  • Contrast agent for abdominal imageology examination

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0028] Example 1 Preparation of contrast agent for abdominal imaging examination

[0029] Preparation of abdominal X-ray radiography contrast agent of experimental group: According to the composition of the experimental group in Table 1, each component was measured, and the abdominal X-ray radiographic imaging contrast agent was prepared according to the following steps. Brief description of the preparation method: mix poloxamer P188 and poloxamer P407, add distilled water, mix well, place at 4°C for 12 hours, mix again, add fine barium sulfate powder, disperse and mix to obtain abdominal X-ray radiography Contrast agent.

[0030] Preparation of contrast agent for abdominal imaging examination of the control group: According to the composition of the control group in Table 1, the contrast agent for abdominal imaging examination of the control group was prepared according to the method of the experimental group.

[0031] Table 1 The composition of contrast media for abdominal X-ray r...

Example Embodiment

[0034] Example 2 Evaluation of the imaging effect of contrast agent in abdominal imaging examination

[0035] Stomach imaging: Beagle dogs (weight 3kg / head) fasted for 18-24h before imaging, cleared the food and debris in the stomach, and injected Sumianxin intramuscularly to anesthetize the dog. Before imaging, the X-ray machine took a plain film, and then injected a 30% weight / volume ratio X-ray radiography contrast agent through the stomach catheter, and injected it at 10 mL / kg body weight. Then turn the animal carefully to make the barium meal fully spread on the stomach wall (turn it to the left and right 3 to 5 times and lift it up and down 2 to 3 times). Then inject air into the stomach at 8-10mL / kg body weight, take out or clamp the outer end of the gastric tube, and turn it around 1-2 times, and immediately adopt the dorsal position (back-abdominal position) and the left position (right position) Filming.

[0036] Small bowel radiography: fast for 8-12 hours, 30-80% X-ra...

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Abstract

The invention provides a contrast agent for abdominal imageology examination. The contrast agent is a mixed solution which is composed of poloxamer P188 and poloxamer P407; and as an imaging contrastagent for stomach, intestinal tract, uterus and vagina and a matrix of the imaging contrast agent, the contrast agent is mixed with an imaging tracer agent and is used as the contrast agent for magnetic resonance imaging, positron emission computed tomography imaging, single photon emission computed tomography, computed tomography, combined imaging of positron emission computed tomography imagingand computed tomography and X-ray radiological imaging. The contrast agent for abdominal imageology examination disclosed by the invention has the characteristics that the contrast agent is simple andquick to use, the safety is high, the volume of the contrast agent keeps invariant, the adhesiveness is good, and natural filling and continuous filling of gastrointestinal tract can be realized.

Description

technical field [0001] The invention relates to an abdominal contrast agent, in particular to a contrast agent for abdominal imaging examination. Background technique [0002] Abdominal examination is the focus of medical imaging examinations. The traditional abdominal examination mainly focuses on gastrointestinal examination, while the uterus and vagina are the focus of gynecological abdominal examination. Currently commonly used examinations include: X-ray, computerized tomography (CT), magnetic resonance imaging (MRI), etc. In order to improve the resolution of images, it is necessary to cooperate with the application of contrast agents. [0003] In abdominal CT examination, gastrointestinal contrast medium is routinely used before the examination. At present, water contrast medium is advocated in upper abdominal CT examination, and positive contrast medium is required to fill the gastrointestinal tract in CT examination of the middle and lower abdomen and pelvis. Alth...

Claims

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Application Information

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IPC IPC(8): A61K49/04A61K49/12A61K51/06A61K101/02
CPCA61K49/04A61K49/0404A61K49/126A61K51/06
Inventor 赵应征鲁翠涛陈斌杨运俊徐荷林姚情
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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