Compound preparation of active ingredients of traditional Chinese medicine for treating vascular dementia and its application

Abstract

The invention relates to the technical field of traditional Chinese medicines. The invention particularly discloses a traditional Chinese medicine effective component compound preparation for treatingvascular dementia and an application thereof. The compound preparation comprises effective components and / or pharmaceutically acceptable auxiliary materials or carriers. The compound preparation is characterized in that effective components consist of ginsenoside Rb3 and beta-asarone; and through the synergistic effect of the ginsenoside Rb3 and the beta-asarone, protection on nerve cells is effectively improved; generation of beta-like precipitated proteins and metabolism of acetylcholine are slowed down, damages caused by free radicals, apoptosis factors and the like are reduced, cognitiveimpairment caused by brain tissue apoptosis necrosis is obviously relieved, and cell apoptosis and cell oxidative stress reaction are inhibited. The compound preparation has a remarkable effect of preventing and treating vascular dementia, is less in medicine flavor and clear in action mechanism and is beneficial to quality control, and the medicine dosage is effectively reduced while the curativeeffect is ensured.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a compound preparation for treating vascular dementia and its application. Background technique [0002] Vascular dementia (VaD) is a clinical syndrome ranging from mild cognitive impairment to dementia on the basis of degeneration of brain cell function caused by various stroke-related factors[1]. VaD is a common senile disease in my country. The clinical manifestations are mainly memory loss and intellectual decline, accompanied by decreased living ability, emotional and behavioral abnormalities, etc. With the increasing aging of our population and the changes in diet structure and daily life, the incidence of stroke and heart disease is also increasing. In recent years, due to the blowout growth of cerebrovascular diseases, people pay more and more attention to the research of VaD. At present, post-stroke dementia has two meanings: ①stroke is the main di...

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Problems solved by technology

Although ginsenosides Rg3, Rg1, Re, Rf, and Rg2 have no significant increase in blood drug concentration after continuous administration [13], ginsenosides Rg1 and Re have the effect of protecting learning and memory, but ginsenosides Rg1, Rg3, and Re are easy to Degraded by enzymes produced by intestinal bacteria, oral bioavailability is very low [14-16]

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