Analysis method for simultaneously determining 11 drugs and metabolites thereof in domestic sewage

Abstract

The invention discloses an analysis method for simultaneously determining 11 drugs and metabolites thereof in domestic sewage. The analysis method comprises the steps of (1) preparing a solution; (2)sample pretreatment: unfreezing a sewage sample to room temperature, then filtering the sewage sample through a glass fiber filter membrane, adding the internal standard stock solution prepared in thestep (1) into 50mL of a domestic sewage sample, and carrying out solid-phase extraction; and (3) respectively carrying out liquid chromatography-tandem mass spectrometry analysis on the domestic sewage samples extracted in the step (2), and establishing an analysis method for simultaneously determining 11 drugs and metabolites thereof in the domestic sewage. The method disclosed by the inventionmeets the requirement of monitoring abuse of medicines at present in China, and is expected to become an important tool for monitoring illegal medicine consumption in the future.

Description

technical field [0001] The invention relates to the technical field of quantitative analysis of drugs in sewage, in particular to an analysis method for simultaneously measuring 11 kinds of drugs and their metabolites in domestic sewage. Background technique [0002] The sources of drug residues and their metabolites in domestic sewage are mainly the excrement of drug addicts and domestic sewage discharged from drug manufacturing sites. The early warning of drug situation can be realized through the analysis of drugs in sewage, which is the current "black technology" in the field of drug control. [0003] At present, the pretreatment methods of domestic sewage mainly include solid-phase extraction and liquid-liquid extraction. However, because the sample processing process of liquid-liquid extraction requires a large amount of organic reagents and takes a lot of time, it is more widely used in the pretreatment of sewage. few. Compared with the traditional liquid-liquid ext...

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Problems solved by technology

The monitoring of drug use was first obtained through population surveys combining crime statistics, medical records, drug production and seizure rates, but this method

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