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Method for detecting trichloroacetic acid in cosmetics by liquid chromatography-mass spectrometry

A technology of trichloroacetic acid and liquid mass spectrometry, which is applied in the field of chemical analysis and detection, can solve the problems of low analysis and detection sensitivity, complex pretreatment process, and long analysis cycle, and achieve short analysis time, improved selectivity and accuracy, The effect of simple and easy pre-processing

Inactive Publication Date: 2017-12-01
苏州出入境检验检疫局检验检疫综合技术中心
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Problems solved by technology

[0005] In order to solve the problems of complex pretreatment process, low analysis and detection sensitivity, poor selectivity, and long analysis period in the instrumental analysis and determination of trichloroacetic acid in the prior art, the present invention establishes sample pretreatment through solid phase extraction technology for the first time, and then combines liquid phase Chromatography-tandem mass spectrometry has established a method for the determination of trichloroacetic acid in cosmetics, which has high sensitivity and accuracy and is suitable for actual entry-exit detection

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  • Method for detecting trichloroacetic acid in cosmetics by liquid chromatography-mass spectrometry
  • Method for detecting trichloroacetic acid in cosmetics by liquid chromatography-mass spectrometry
  • Method for detecting trichloroacetic acid in cosmetics by liquid chromatography-mass spectrometry

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Embodiment

[0042] Testing steps of cosmetics to be tested

[0043] (1) Sample pretreatment and test sample preparation

[0044] Accurately weigh 0.5 g of the sample to be tested (accurate to 0.0001 g) with an electronic balance, place it in a 10 mL plastic centrifuge tube, add 5 mL of water, vortex for 60 s, perform ultrasonic extraction for 15 min, and then centrifuge at 10,000 rpm for 10 min , take the supernatant and pass through a 0.45 μm microporous membrane to obtain an extract solution;

[0045] To activate the C18 cartridge, activate the C18 cartridge with 10 mL of methanol and 15 mL of water in sequence, and then let it stand for 30 minutes to prepare for sample loading;

[0046] The extract solution filtered through the membrane was loaded on the C18 small column, and then the receiving solution was filtered through a 0.22 mm filter membrane and then analyzed on the machine.

[0047] (2) Separation and analysis of the sample solution prepared above by high performance liquid ...

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Abstract

The invention discloses a method for detecting trichloroacetic acid in cosmetics by a liquid chromatography-mass spectrometry. According to the method, cosmetic samples to be detected are pretreated by the aid of solid-phase extraction technique and qualitatively detected by a high-performance liquid chromatography and a mass spectroscopy, and the trichloroacetic acid in the cosmetics is quantitatively analyzed by an external standard method. According to the method, the cosmetic samples are pretreated by the aid of the solid-phase extraction technique, a detection method of the trichloroacetic acid in the cosmetics is built by the aid of liquid chromatography-tandem mass spectrum technique, and the method has the advantages of simple, convenient and easy pretreatment, short analysis time, low detection limit, high in recovery rate and good stability. The content of trichloroacetic acid in complex substances can be rapidly, simply, conveniently and accurately detected.

Description

technical field [0001] The invention belongs to the field of chemical analysis and detection, and in particular relates to a method for detecting trichloroacetic acid in cosmetics by liquid mass spectrometry. Background technique [0002] The research on the health risks of haloacetic acids to humans originated from the disinfection of drinking water. Disinfection by-products in drinking water are mainly trihalomethanes and haloacetic acids. The concentration of these two types of disinfection by-products is far higher than that of other disinfection by-products, and its carcinogenic risk has been confirmed by toxicology and biology. The primary indicator parameter. [0003] Among the haloacetic acids, the carcinogenic risk per unit concentration of dichloroacetic acid and trichloroacetic acid (TCAA) is relatively high. They are regarded as representatives of haloacetic acids, which are chlorinated disinfection by-products, and their unit carcinogenic risk is 2.6 ´ 10 -6...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 徐振东张嵘顾娟红樊继鹏朱振华
Owner 苏州出入境检验检疫局检验检疫综合技术中心
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