7 results about "Haloacetic acids" patented technology

The present invention provides an industrially desirable production method for a sulfone derivative that is useful as a herbicide, and an intermediate thereof.

The invention discloses a novel graphene oxide adsorption film and application thereof, and belongs to the technical field of film separation. Comprising the following steps: mixing a graphene oxide ethanol dispersion liquid with an RCC3 molecular cage aqueous solution, and carrying out ultrasonic dispersion and constant-temperature stirring reaction, so that a secondary amine group in a molecular cage and an epoxy group on the surface of graphene oxide are subjected to a nucleophilic ring-opening reaction, and covalent linkage is realized; and then coating the functionalized suspension on a porous membrane substrate to form an adsorption layer, carrying out protonation treatment through vacuum filtration of a hydrochloric acid solution, and finally drying and curing to obtain a finished product. The membrane can efficiently and selectively adsorb haloacetic acid disinfection byproducts (the rejection rate is greater than or equal to 90%) in drinking water, meanwhile, beneficial inorganic salt ions such as calcium, magnesium and sodium are allowed to permeate (the transmittance is greater than or equal to 80%), and high flux, high selectivity and anti-swelling stability are effectively considered. The preparation process is simple and controllable, is suitable for waterworks, underground water purification, industrial wastewater treatment and other scenes, and has significant industrialization potential.

This invention discloses a method for the electrocatalytic hydrogenation dehalogenation of haloacetic acids or halomethanes in water. A conductive material surface-modified with ruthenium or platinum is used as the catalytic cathode, and water is used as the hydrogen source to electrochemically hydrogenate and dehalogenate haloacetic acids or halomethanes in water into acetic acid or methane. The precious metals in the catalytic cathode of this invention are cheaper; the unit price of ruthenium is much lower than that of palladium and rhodium. Compared with palladium-modified catalytic cathodes, the dechlorination selectivity is higher, with an 11.7% increase in the selectivity for the hydrogenation and dechlorination of trichloroacetic acid in water to acetic acid.

The application relates to the technical field of organic synthesis and pharmaceutical intermediates, in particular to a (2S, 4R)-1-Fmoc-4-(O-allyloxycarbonylmethyl)-proline and a synthesis method thereof. The method comprises the following steps: performing silicon-based protection on (2S, 4R)-4-hydroxypyrrolidine-2-carboxylic acid; refluxing and dehydrating the alkyl aldehyde to construct a tetrahydropyrrolooxazolone bicyclic intermediate; after the silicon-based group is removed, etherification is performed with 2-haloacetic acid allyl ester under strong alkali to introduce a side chain; and finally, acid ring-opening hydrolysis and Fmoc protection are performed to obtain the target product. The amino group and the carboxyl group are protected in situ by constructing a bicyclic structure, the sensitive allyloxycarbonylmethyl side chain is introduced in a non-water system, and the hydrolysis of the side chain ester bond is effectively avoided. The product prepared by the application has high purity and good stereoselectivity, and an efficient and low-cost industrialization approach is provided for the synthesis of high-performance polypeptide blocks.

The invention discloses application of haloacetic acid in enrichment of small molecule nucleic acid in a biological sample, and belongs to the technical field of molecular biology. According to the application, the haloacetic acid is utilized to enrich the micromolecular nucleic acid in the liquid biological sample, so that not only can the influence of interferents be eliminated, but also the enriched micromolecular nucleic acid sample can be stably stored at room temperature, and the micromolecular nucleic acid sample can be directly subjected to amplification detection without being extracted, so that the application value is very important.

The invention relates to the technical field of organic synthesis and medical intermediates, in particular to (2S, 4R)-1-Fmoc-4-(O-allyloxycarbonyl methyl)-proline and a synthesis method thereof. The method comprises the following steps: carrying out silicon group protection on (2S, 4R)-4-hydroxypyrrolidine-2-carboxylic acid; carrying out reflux dehydration on the tetrahydropyrrolo-oxazolone and alkyl aldehyde to construct a tetrahydropyrrolo-oxazolone bicyclic intermediate; after removing a silicon base, etherifying with 2-halogenated allyl acetate under strong base to introduce a side chain; and finally, carrying out acidic ring-opening hydrolysis and Fmoc protection to obtain a target product. According to the preparation method, amino and carboxyl are subjected to in-situ protection by constructing a bicyclic structure, and a sensitive allyloxycarbonyl methyl side chain is introduced by utilizing an anhydrous non-aqueous phase system, so that hydrolysis of ester bonds of the side chain is effectively avoided. The prepared product is high in purity and good in stereoselectivity, and an efficient and low-cost industrial approach is provided for synthesis of high-performance polypeptide building blocks.

The application discloses a method for electrocatalytic hydrogenation dehalogenation of haloacetic acid in water by using a ruthenium / nickel hydroxide catalyst, wherein a conductive material with a surface modified ruthenium / nickel hydroxide is used as a catalytic cathode, the cathode potential is-0.3~‑1.0 V vs. silver / silver chloride reference electrode, and water is used as a hydrogen source, so that the haloacetic acid in water is electrochemically hydrogenated and dehalogenated into acetic acid. Under the condition of the same Ru loading, the catalytic activity of Ru / Ni(OH)2 is higher, the conversion rate of trichloroacetic acid is 9% higher, the acetic acid yield is 14% higher, and the acetic acid selectivity is 5% higher.