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3 results about "Haloacetic acids" patented technology
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Haloacetic acids are carboxylic acids in which a halogen atom takes the place of a hydrogen atom in acetic acid. Thus, in a monohaloacetic acid, a single halogen would replace a hydrogen atom. For example, chloroacetic acid would have the structural formula CH₂ClCO₂H. In the same manner, in dichloroacetic acid two chlorine atoms would take the place of two hydrogen atoms (CHCl₂CO₂H). The inductive effect caused by the electronegative halogens often result in the higher acidity of these compounds by stabilising the negative charge of the conjugate base.
Method for producing sulfone derivative using haloacetic acid
The present invention provides an industrially desirable production method for a sulfone derivative that is useful as a herbicide, and an intermediate thereof.
Owner:KUMIAI CHEM IND CO LTD
A (2S, 4R)-1-Fmoc-4-(O-allyloxycarbonylmethyl)-proline and a method for synthesizing the same
The application relates to the technical field of organic synthesis and pharmaceutical intermediates, in particular to a (2S, 4R)-1-Fmoc-4-(O-allyloxycarbonylmethyl)-proline and a synthesis method thereof. The method comprises the following steps: performing silicon-based protection on (2S, 4R)-4-hydroxypyrrolidine-2-carboxylic acid; refluxing and dehydrating the alkyl aldehyde to construct a tetrahydropyrrolooxazolone bicyclic intermediate; after the silicon-based group is removed, etherification is performed with 2-haloacetic acid allyl ester under strong alkali to introduce a side chain; and finally, acid ring-opening hydrolysis and Fmoc protection are performed to obtain the target product. The amino group and the carboxyl group are protected in situ by constructing a bicyclic structure, the sensitive allyloxycarbonylmethyl side chain is introduced in a non-water system, and the hydrolysis of the side chain ester bond is effectively avoided. The product prepared by the application has high purity and good stereoselectivity, and an efficient and low-cost industrialization approach is provided for the synthesis of high-performance polypeptide blocks.
Owner:HANGZHOU AOSINO PHARMACEUTICAL TECHNOLOGY CO LTD
A method for electrocatalytic hydrodehalogenation of haloacetic acids in water by using a ruthenium / nickel hydroxide catalyst
PendingCN122144857AWater contaminantsWater/sewage treatment by reductionPtru catalystConductive materials
The application discloses a method for electrocatalytic hydrogenation dehalogenation of haloacetic acid in water by using a ruthenium / nickel hydroxide catalyst, wherein a conductive material with a surface modified ruthenium / nickel hydroxide is used as a catalytic cathode, the cathode potential is-0.3~‑1.0 V vs. silver / silver chloride reference electrode, and water is used as a hydrogen source, so that the haloacetic acid in water is electrochemically hydrogenated and dehalogenated into acetic acid. Under the condition of the same Ru loading, the catalytic activity of Ru / Ni(OH)2 is higher, the conversion rate of trichloroacetic acid is 9% higher, the acetic acid yield is 14% higher, and the acetic acid selectivity is 5% higher.
Owner:ZHEJIANG UNIV OF TECH