Gastrointestinal dynamic simulation device

Abstract

The invention provides a gastrointestinal dynamic simulation device. The device comprises a stomach simulation cavity, an intestine simulation cavity, a blood simulation cavity, a liquid storage device and samplers. A medicine basket in which medicines can be put is arranged in the stomach simulation cavity, and artificial gastric juice and artificial intestinal juice can be injected into the cavity. A simulated intestinal wall is attached and embedded between the blood simulation cavity and the intestine simulation cavity, and PH regulating liquid can be injected into the intestine simulationcavity. Human tissue fluid or simulated blood can be injected into the blood simulation cavity. Media in the cavities are sampled through the samplers on the stomach simulation cavity and the blood simulation cavity. The device is simple in structure and convenient to use, a dissolution medium for simulating artificial gastric juice and intestinal juice is added, medicine absorption testing is carried out by simulating the intestinal wall and sampling under the action of an air bag and a stirrer, in-vitro and in-vivo correlation is greatly improved, and the device can be used for predicting in-vitro release and in-vivo absorption of solid oral preparations.

Description

technical field [0001] The invention relates to the technical field of drug dissolution testing, in particular to a device for simulating drug absorption in the gastrointestinal tract of a human body. Background technique [0002] The gastrointestinal tract is the main place for the human body to digest food. The stomach mixes the drug and gastric secretion fluid through peristalsis, making the drug particles grind smaller, and part of the biochemical reaction occurs in the stomach, and then enters the intestine and is greatly digested under the action of intestinal digestive juice. Part of it is digested so that the food is more conducive to the body's digestion and absorption. [0003] At present, there are mainly two methods for studying the kinetic characteristics of pharmaceutical preparations. One is to investigate the disintegration and dissolution properties of drugs, that is, the Pharmacopoeia of the People's Republic of China (hereinafter referred to as the "Pharm...

AI Technical Summary

Problems solved by technology

One is to investigate the disintegration and dissolution properties of drugs, that is, the Pharmacopoeia of the People's Republic of China (hereinafter referred to as the "Pharmacopoeia") has recorded the dissolution test since 1985, and this method is still used in the "Pharmacopoeia" (21st Edition, Part 2) It is an important method for testing the dissolution of pharmaceutical preparations, but its limitation is that this method is mixed by stirring or rotating to generate forced convection in a single dissolution medium, and cannot investigate the process of migration from the stomach (pH 1-2) to the intestine (pH 5- 8) The impact of sharp pH dynamic changes in the process on drug solubility, stability, and drug release; the other is the study of bioavailability, which examines the degree of drug absorption in the body. Currently, the pharmacokinetics in Beagle dogs is mainly used scientific research, this method is time-consuming, costly, and has large individual differences

Images