Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Gastrointestinal dynamic simulation device

A dynamic simulation, gastrointestinal technology, applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of inability to investigate drug solubility, stability and the impact of drug release, time-consuming, and high cost, and achieve complete drug digestion. Effect

Pending Publication Date: 2020-07-21
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE +1
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One is to investigate the disintegration and dissolution properties of drugs, that is, the Pharmacopoeia of the People's Republic of China (hereinafter referred to as the "Pharmacopoeia") has recorded the dissolution test since 1985, and this method is still used in the "Pharmacopoeia" (21st Edition, Part 2) It is an important method for testing the dissolution of pharmaceutical preparations, but its limitation is that this method is mixed by stirring or rotating to generate forced convection in a single dissolution medium, and cannot investigate the process of migration from the stomach (pH 1-2) to the intestine (pH 5- 8) The impact of sharp pH dynamic changes in the process on drug solubility, stability, and drug release; the other is the study of bioavailability, which examines the degree of drug absorption in the body. Currently, the pharmacokinetics in Beagle dogs is mainly used scientific research, this method is time-consuming, costly, and has large individual differences

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gastrointestinal dynamic simulation device
  • Gastrointestinal dynamic simulation device
  • Gastrointestinal dynamic simulation device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] The present invention will be further described below according to accompanying drawing.

[0023] Such as figure 1 and figure 2 As shown, a gastrointestinal dynamic simulation device includes a base 1 , a stomach simulation chamber 2 , an intestinal simulation chamber 3 , a blood simulation chamber 4 , a liquid storage device 5 , a first sampler 9 and a second sampler 10 .

[0024] The base 1 is divided into a left area, a middle area and a right area, the left area is used to place the gastric simulation cavity 2 and the liquid storage device 5, the middle area is used to place the first sampler 9 and the second sampler 10, and the right The inner area is used to place the intestinal simulation chamber 3 and the blood simulation chamber 4.

[0025] Among them, a heating / constant temperature device 11 is installed above the rear end of the left area, and the middle position is used to place the gastric simulation chamber 2. The gastric simulation chamber 2 is a disso...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a gastrointestinal dynamic simulation device. The device comprises a stomach simulation cavity, an intestine simulation cavity, a blood simulation cavity, a liquid storage device and samplers. A medicine basket in which medicines can be put is arranged in the stomach simulation cavity, and artificial gastric juice and artificial intestinal juice can be injected into the cavity. A simulated intestinal wall is attached and embedded between the blood simulation cavity and the intestine simulation cavity, and PH regulating liquid can be injected into the intestine simulationcavity. Human tissue fluid or simulated blood can be injected into the blood simulation cavity. Media in the cavities are sampled through the samplers on the stomach simulation cavity and the blood simulation cavity. The device is simple in structure and convenient to use, a dissolution medium for simulating artificial gastric juice and intestinal juice is added, medicine absorption testing is carried out by simulating the intestinal wall and sampling under the action of an air bag and a stirrer, in-vitro and in-vivo correlation is greatly improved, and the device can be used for predicting in-vitro release and in-vivo absorption of solid oral preparations.

Description

technical field [0001] The invention relates to the technical field of drug dissolution testing, in particular to a device for simulating drug absorption in the gastrointestinal tract of a human body. Background technique [0002] The gastrointestinal tract is the main place for the human body to digest food. The stomach mixes the drug and gastric secretion fluid through peristalsis, making the drug particles grind smaller, and part of the biochemical reaction occurs in the stomach, and then enters the intestine and is greatly digested under the action of intestinal digestive juice. Part of it is digested so that the food is more conducive to the body's digestion and absorption. [0003] At present, there are mainly two methods for studying the kinetic characteristics of pharmaceutical preparations. One is to investigate the disintegration and dissolution properties of drugs, that is, the Pharmacopoeia of the People's Republic of China (hereinafter referred to as the "Pharm...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/00G01N33/15
CPCG01N33/00G01N33/15
Inventor 何新王洋洋黄聪刘朝群齐子楠刘振国洪良艺石立强
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com