Cyclic formyl and cyclic ketone compounds as well as preparation method and pharmaceutical application thereof

Abstract

The invention discloses cyclic formyl and cyclic ketone compounds as well as a preparation method and a pharmaceutical application thereof. The compound shown in (I) has a good function of inhibitinginfection and replication of Zika viruses and dengue viruses; the compounds can be used as medicines for treating and preventing diseases caused by Zika virus and dengue virus. The compound can be used as a medicine for treating and preventing diseases caused by other flaviviruses, such as yellow fever, west nile virus infection, encephalitis B caused by encephalitis B virus infection, chikungunyavirus infection, hepatitis C, forest encephalitis, AIDS caused by HIV, diseases caused by hand-foot-and-mouth virus infection and the like. The compound can be used for treating diseases caused by bacterial infection, including ulcerative colitis and Crohn's disease of inflammatory bowel disease, diseases caused by escherichia coli, diseases caused by staphylococcus aureus and the like, and diseases caused by acinetobacter baumannii.

Description

technical field [0001] The invention belongs to the technical field of medicinal chemistry, and in particular relates to cycloformyl and cycloyl ketone compounds, their preparation method and pharmaceutical application. Background technique [0002] Zika virus (ZIKV), dengue virus (DENV), flavivirus (YFV), West Nile virus (WNV), Japanese encephalitis virus (JEV) of the family Flaviviridae and chikungunya of the alphavirus genus The viruses (CHIKV) are all arboviruses, and they are similar in many aspects of their life cycles. The main vector of these arboviruses, Aedesmosquito (including Aedes aegypti, Aedes albopictus and Aedes polynesiensis) is one of the largest mosquitoes in the world, living in All continents of the world except Antarctica. Symptoms of dengue fever-like illness generally appear 3-14 days after being bitten by an infectious Aedes mosquito (average 4-7 days). [0003] What is more special is that DENV has 4 serotypes. Although there is 65–70% similarit...

AI Technical Summary

Problems solved by technology

[0004] Under the influence of many factors such as the deterioration of the global environment and warming, the epidemics of dengue fever and Zika have been expanding in recent years. However, there is currently only one dengue vaccine in a limited area. There is no Zika virus vaccine or other vaccines, and there is no effective anti-virus vaccine. Zika virus or anti-dengue virus drugs can be used in the clinical treatment of dengue fever disease, and now clinical treatment is mainly progressive supportive therapy (intensive supportive therapy), in which maintaining fluid balance is the main means

Images