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A kind of pharmaceutical composition for treating pelvic floor achalasia type constipation and preparation method thereof

A composition and achalasia technology, applied in the field of medicine, can solve the problems of poor long-term treatment effect of surgical treatment, long course of biofeedback therapy, and increased treatment burden of patients, etc., to achieve significant curative effect, improved curative effect, and comprehensive effect Effect

Active Publication Date: 2021-08-10
THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the course of biofeedback therapy is long, and the whole process requires continuous training of patients, which increases the burden of treatment on the one hand, and on the other hand, the final success rate of this method is low
[0009] In severe cases, surgical intervention is required. Studies have shown that most surgical treatments can achieve good results in the early stage, but the disease is prone to relapse with the passage of time. In addition, the re-formation of postoperative scars will cause postoperative defecation problems in patients recurrence, the long-term treatment effect of surgical treatment is not good
[0010] According to the analysis, the current methods for the treatment of pelvic floor achalasia constipation lack a drug with good therapeutic effect, quick effect and long-lasting effect. It is urgent for researchers to solve the above problems

Method used

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  • A kind of pharmaceutical composition for treating pelvic floor achalasia type constipation and preparation method thereof
  • A kind of pharmaceutical composition for treating pelvic floor achalasia type constipation and preparation method thereof
  • A kind of pharmaceutical composition for treating pelvic floor achalasia type constipation and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1 compound tablet

[0038]

[0039] Preparation process: mix buspirone, polyethylene glycol 4000 and microcrystalline cellulose, add 6% PVP ethanol solution to the mixture, and pass through a 20-mesh sieve to granulate. The wet granules are dried at 50°C. After drying, the granules are passed through a 20-mesh sieve for granulation, and the fine powder in the dry granules is sifted out, mixed with magnesium stearate, and then mixed with the dry granules, and pressed into tablets to obtain the product.

Embodiment 2

[0040] The preparation of embodiment 2 compound suppositories

[0041]

[0042]

[0043] Preparation process: Take Tween and mix it with glycerin in a vessel, stir evenly, add the prescribed amount of paroxetine and lactulose, continue to stir evenly, pour into the plug mold coated with lubricant until it slightly overflows the mold mouth, cool, and solidify Finally, the overflow part is cut off, demoulding, quality inspection, and packaging.

Embodiment 3

[0044] The preparation of embodiment 3 dispersible tablets

[0045]

[0046] Preparation process: Weigh and mix citalopram and polyethylene glycol 5000 according to the prescription quantity, use microcrystalline cellulose as filler, polyvinylpyrrolidone as disintegrant, 60% ethanol solution as binder, and micronized silica gel as flow aid , using a fluidized bed to granulate in one step, and then compressed into tablets.

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Abstract

The invention discloses a pharmaceutical composition for treating pelvic floor achalasia constipation and a preparation method thereof. The pharmaceutical composition mainly uses pharmaceutically acceptable osmotic laxatives and anxiolytics, wherein the osmotic laxatives and anxiolytics The weight ratio of the drugs is 2-8:1, and the drug combination of the pharmaceutical composition has a significant synergistic effect. Through the specific drug ratio, the toxic and side effects of the two drugs on the human body are significantly reduced, and the anal muscles, especially the sphincter, are significantly reduced. The pressure can reduce the maximum spontaneous systolic pressure of the anorectum and the resting pressure of the anorectum, improve the curative effect of the pharmaceutical composition, and has broad medical application prospects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating pelvic floor achalasia type constipation and a preparation method thereof. Background technique [0002] Constipation is one of the most common gastrointestinal symptoms clinically. It often manifests as strained defecation, decreased frequency of defecation, induration or dry ball of defecation, feeling of incomplete defecation, anorectal blockage, and even assisted defecation with manipulation. Chronic constipation has been underestimated by people for quite a long time in the past. In recent years, the prevalence of constipation has gradually increased, and studies have shown that it is closely related to acute cardiovascular and cerebrovascular diseases, dementia, and colorectal cancer. More and more attention. [0003] The Rome II standard was introduced in 2000, and the international concept of constipation uses the Ro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/765A61K31/506A61K31/4525A61K31/343A61K31/7016A61P1/10A61P15/00
CPCA61K31/343A61K31/4525A61K31/506A61K31/7016A61K31/765A61K45/06A61P1/10A61P15/00
Inventor 刘艳姜伟
Owner THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIV
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