Radix rehmanniae extract and preparation method thereof, and radix rehmanniae traditional Chinese medicine formula granules and preparation method thereof

A technology of traditional Chinese medicine formula granules and fresh rehmannia, which is applied in medical formulas, medical preparations containing active ingredients, antineoplastic drugs, etc., and can solve problems such as the difficulty of ultrasonic extraction for industrial production, unfavorable popularization and use, and difficulty in storage and transportation of fresh rehmannia

Inactive Publication Date: 2020-10-20
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method solves the problems of difficult storage and transportation of fresh rehmannia glutinosa and inconvenient clinical use to a certain extent, but it also has unavoidable defects:
[0009] 3. Ultrasonic extraction is difficult to achieve industrial production, which is not conducive to popularization and use

Method used

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  • Radix rehmanniae extract and preparation method thereof, and radix rehmanniae traditional Chinese medicine formula granules and preparation method thereof
  • Radix rehmanniae extract and preparation method thereof, and radix rehmanniae traditional Chinese medicine formula granules and preparation method thereof
  • Radix rehmanniae extract and preparation method thereof, and radix rehmanniae traditional Chinese medicine formula granules and preparation method thereof

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preparation example Construction

[0036] A preparation method of fresh rehmannia glutinosa extract, comprising the steps of:

[0037] The fresh rehmannia medicinal material is crushed after being sterilized by moist heat to prepare fresh rehmannia decoction pieces;

[0038] The fresh rehmannia decoction pieces are subjected to continuous dynamic countercurrent extraction, the extraction solvent of the continuous dynamic countercurrent extraction is water, and the extract is collected.

[0039] The main active ingredient of fresh rehmannia glutinosa is catalpol, which belongs to iridoid glycosides, and its physical and chemical properties are extremely unstable: (1) catalpol is easily oxidized and degraded during the storage and processing of fresh rehmannia glutinosa. The main reason for easy blackening; (2) catalpol is easily hydrolyzed by β-glucosidase in medicinal materials during the storage of fresh rehmannia glutinosa. In fresh medicinal materials, the enzyme does not contact with the chemical component...

Embodiment 1

[0060] This embodiment provides the preparation method of fresh rehmannia glutinosa extract and the preparation method of fresh rehmannia glutinosa formula granules, and its technological process is as follows figure 1 As shown, the details are as follows:

[0061] (1) Remove the reed heads, fibrous roots and sediment from the harvested rehmannia glutinosa while it is fresh, wash it and put it into a high-pressure steam sterilization box, sterilize at 121°C for 5 minutes, and the steam pressure is 0.103MPa;

[0062] (2) Put the sterilized fresh rehmannia glutinosa into the crusher, and crush it to obtain fresh rehmannia glutinosa decoction pieces;

[0063] (3) Put the fresh rehmannia root slices into the spiral continuous dynamic countercurrent extraction machine, add 12 times the amount of 80°C hot water for continuous countercurrent extraction for 1 hour, collect the extract, squeeze the fresh rehmannia root to recover part of the medicinal solution, and then discharge it ,...

Embodiment 2

[0067] This embodiment provides the preparation method of fresh rehmannia glutinosa extract and the preparation method of fresh rehmannia glutinosa formula granules, specifically as follows:

[0068] (1) Remove the reed heads, fibrous roots and sediment from the harvested rehmannia glutinosa while it is fresh, wash it and put it into a high-pressure steam sterilization box, sterilize at 121°C for 5 minutes, and the steam pressure is 0.103MPa;

[0069] (2) Put the sterilized fresh rehmannia glutinosa into the crusher, and crush it to obtain fresh rehmannia glutinosa decoction pieces;

[0070] (3) Put the fresh rehmannia root slices into the spiral continuous dynamic countercurrent extraction machine, add 12 times the amount of 80°C hot water for continuous countercurrent extraction for 1 hour, collect the extract, squeeze the fresh rehmannia root to recover part of the medicinal solution, and then discharge it , the recovered part of the medicinal liquid is combined with the ex...

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Abstract

The invention relates to a radix rehmanniae extract and a preparation method thereof, and a preparation method of radix rehmanniae traditional Chinese medicine formula granules. The preparation methodof the radix rehmanniae extract comprises the following steps of carrying out moist heat sterilization on radix rehmanniae medicinal material, and crushing to prepare radix rehmanniae decoction pieces; and carrying out continuous dynamic countercurrent extraction on the radix rehmanniae decoction pieces, wherein a solvent for continuous dynamic countercurrent extraction is water. The radix rehmanniae extract obtained by the preparation method not only has a high paste yield, but also can maximally retain the catalpol, which is the main active ingredient of the radix rehmanniae, so that uniform, stable, safe and effective radix rehmanniae traditional Chinese medicine formula granules can be further obtained.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a fresh rehmannia glutinosa extract and a preparation method thereof, and fresh rehmannia glutinosa traditional Chinese medicine formula granules containing the same. Background technique [0002] Fresh Rehmannia glutinosa is the fresh tuber root of Rehmannia glutinosa Libosch., which is sweet, bitter, and cold in nature. It has the effects of clearing away heat, promoting body fluid, cooling blood, and stopping bleeding. Toxic hair spots, vomiting blood, epistaxis, sore throat. Modern pharmacological research shows that fresh rehmannia glutinosa has good anti-oxidation, hypoglycemic, hemostatic and immune effects. [0003] Slowly roast fresh rehmannia until about 80% dry to get raw rehmannia. Due to the limitations of fixed harvest cycle, difficult storage and transportation, and inconvenient clinical adjustment, the clinical application of fresh rehmannia glutinosa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/16A61P39/06A61P35/00
CPCA61K9/16A61K36/804A61K2236/10A61K2236/331A61K2236/39A61K2236/51A61P35/00A61P39/06
Inventor 张正徐杰梁志毅田清清黄梦婷彭邦贵邓李红王寿富程学仁
Owner GUANGDONG YIFANG PHARMA
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