A durable and stable hydrophilic antifouling coating for intraocular lens and preparation method thereof

A technology for intraocular lenses and hydrophilic coatings, applied in coatings, prostheses, pharmaceutical formulations, etc., can solve problems such as insufficient anti-fouling performance, improve hydrophilicity and anti-fouling properties, maintain mechanical properties, and flexibly combine Effect

Active Publication Date: 2021-09-21
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides a durable and stable hydrophilic anti-fouling coating for intraocular lenses and a preparation method thereof, in which a durable and stable hydrophilic anti-fouling coating is coated on the surface of the intraocular lens, which has very Good hydrophilicity and anti-fouling properties, its anti-protein adsorption, anti-bacterial pollution, anti-cell adhesion and anti-thrombosis performance is good, avoiding the large amount of protein, cells and The problem of bacterial adhesion

Method used

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  • A durable and stable hydrophilic antifouling coating for intraocular lens and preparation method thereof
  • A durable and stable hydrophilic antifouling coating for intraocular lens and preparation method thereof
  • A durable and stable hydrophilic antifouling coating for intraocular lens and preparation method thereof

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Effect test

Embodiment 1

[0029] A durable and stable hydrophilic antifouling coating for an intraocular lens, the preparation method of which comprises the following steps:

[0030] (1) Configure a polyoxyethylene solution with a concentration of 10 mg / ml;

[0031] (2) The surface of the hard polymethyl methacrylate intraocular lens material is subjected to low-temperature plasma surface treatment at a voltage of 70V for 60s to obtain a pretreated hard polymethyl methacrylate intraocular lens material;

[0032] (3) Put the pretreated rigid polymethyl methacrylate intraocular lens material obtained in step (2) into the polyoxyethylene solution obtained in step (1) and immerse it for 30 minutes, take it out, dry it with nitrogen, and then put it under the conditions of 150V and 0.01Pa vacuum degree Under the superheated hydrogen cross-linking modification treatment for 35s, a durable and stable hydrophilic anti-fouling coating for intraocular lenses was obtained.

Embodiment 2

[0034] A durable and stable hydrophilic antifouling coating for an intraocular lens, the preparation method of which comprises the following steps:

[0035] (1) configure a polyvinylpyrrolidone solution with a concentration of 6 mg / ml;

[0036] (2) The surface of the hard polymethyl methacrylate intraocular lens material is subjected to low-temperature plasma surface treatment at a voltage of 150V for 20s to obtain a pretreated hard polymethyl methacrylate intraocular lens material;

[0037] (3) Put the pretreated rigid polymethyl methacrylate intraocular lens material obtained in step (2) into the polyvinylpyrrolidone solution obtained in step (1) and immerse it for 30 minutes, take it out, dry it with nitrogen, and then vacuum it at 200V and 0.01Pa The superthermal hydrogen cross-linking modification treatment was carried out under the conditions for 180s to obtain a durable and stable hydrophilic anti-fouling coating for intraocular lenses.

Embodiment 3

[0039] A durable and stable hydrophilic antifouling coating for an intraocular lens, the preparation method of which comprises the following steps:

[0040] (1) Configure a polyoxyethylene solution with a concentration of 8 mg / ml;

[0041] (2) The surface of the polyhydroxyethyl methacrylate intraocular lens material is subjected to low-temperature plasma surface treatment at a voltage of 120V for 120s to obtain a pretreated polyhydroxyethyl methacrylate intraocular lens material;

[0042] (3) Put the pretreated polyhydroxyethyl methacrylate intraocular lens material obtained in step (2) into the polyoxyethylene solution obtained in step (1) and immerse it for 30 minutes, take it out, dry it with nitrogen, and then put it under the conditions of 100V and 0.2Pa vacuum degree The superthermal hydrogen cross-linking modification treatment was carried out for 120s to obtain a durable and stable hydrophilic antifouling coating for intraocular lenses.

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Abstract

The invention discloses a durable and stable hydrophilic antifouling coating for an intraocular lens and a preparation method thereof. The preparation method includes the following steps: preparing a hydrophilic coating solution with a concentration of 1.5-30 wt%; Surface treatment, the intraocular lens material must be pretreated; the hydrophilic coating solution is applied to the surface of the pretreated intraocular lens material, and then superheated hydrogen cross-linking modification treatment is performed to obtain a durable and stable hydrophilic antifouling coating for intraocular lenses. . The present invention also includes the hydrophilic antifouling coating obtained by the above method. The invention coats a durable and stable hydrophilic antifouling coating on the surface of the intraocular lens, has good hydrophilicity and antifouling properties, and has good anti-protein adsorption, anti-bacterial pollution, anti-cell adhesion and anti-thrombotic properties. It avoids the problem of the adhesion of a large number of proteins, cells and bacteria due to the insufficient anti-fouling properties of the surface of the intraocular lens after implantation.

Description

technical field [0001] The invention belongs to the technical field of ophthalmic medical implant materials, in particular to a durable and stable hydrophilic antifouling coating for intraocular lenses and a preparation method thereof. Background technique [0002] Cataract is a common eye disease that occurs on the lens in the human eye. As long as the lens is cloudy, it can be called cataract. The pathogenic factors include many factors, such as aging, heredity, local nutritional disorders, immune and metabolic abnormalities, trauma, poisoning or radiation, etc. These factors can cause lens metabolic disorders, which in turn lead to lens protein denaturation and turbidity. Cataracts form. Cataracts are one of the most common causes of blindness and visual disability. So far, the world-recognized direct and effective method of treating cataract is surgical treatment, that is, the original cloudy lens is taken out and implanted with an intraocular lens through surgery. ...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61L27/34A61L27/50
CPCA61L27/34A61L27/50A61L2400/18A61L2420/02A61L2430/16C08L71/02C08L39/06C08L5/10
Inventor兰小蓉王云兵何周坤雷洋
OwnerSICHUAN UNIV