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Peritoneal dialysate fluid, peritoneal dialysate fluid set, composition for use in peritoneal dialysis, and peritoneal dialysis method

A technology of peritoneal dialysis solution and peritoneal dialysis, applied in peritoneal dialysis, dialysis system, drug combination, etc., can solve problems such as undisclosed countermeasures

Pending Publication Date: 2020-10-30
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The peritoneal dialysis fluid without residual sodium exhibits the expected performance when the one-time storage time is limited to 4 hours, but in actual clinical use, the storage time is in the range of 2 to 11 hours , the risk of hyponatremia caused by excessive sodium removal and the impact on residual renal function in the case of daily administration or continuous administration are not clarified, and the solution to this problem is not disclosed at all.

Method used

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  • Peritoneal dialysate fluid, peritoneal dialysate fluid set, composition for use in peritoneal dialysis, and peritoneal dialysis method
  • Peritoneal dialysate fluid, peritoneal dialysate fluid set, composition for use in peritoneal dialysis, and peritoneal dialysis method
  • Peritoneal dialysate fluid, peritoneal dialysate fluid set, composition for use in peritoneal dialysis, and peritoneal dialysis method

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Embodiment

[0058] The effects of the present invention will be described using the following examples and comparative examples. However, the technical scope of the present invention is not limited to the following examples. In addition, in the following examples, although the expression of "part" or "%" may be used, unless otherwise specified, it means "weight part" or "weight%". In addition, unless otherwise stated, each operation was performed at room temperature (1-30 degreeC).

[0059]

[0060] Anhydrous glucose, sodium chloride, calcium chloride dihydrate, magnesium chloride hexahydrate, and L-sodium lactate Each required amount of the solution was prepared according to the method for injection in the Japanese Pharmacopoeia General Rules for Preparations, and filtered with a membrane filter. The filtered dialysate was dispensed into a container made of polypropylene resin for peritoneal perfusion suitable for the two-chamber container test method, and sealed. Then, after sealin...

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Abstract

The present invention provides a means which can appropriately control the balance between water and sodium in peritoneal dialysis therapies while avoiding adverse effects on the residual renal function and without causing hyponatremia. This peritoneal dialysate fluid contains 1.5 to 1.8 w / v% of glucose and 120 to 130 mEq / L of sodium, and is used alone one or two times a day. The peritoneal dialysate fluid is used in combination with another peritoneal dialysate fluid containing 1.35 to 2.5 w / v% of glucose and 132 to 135 mEq / L of sodium in peritoneal dialysis where the following steps are performed three to five times a day: injecting 1.5 to 2.0 L of a peritoneal dialysate fluid into the abdominal cavity of a subject; retaining the peritoneal dialysate fluid; and discharging the peritonealdialysate fluid.

Description

technical field [0001] The present invention relates to peritoneal dialysis fluid, peritoneal dialysis fluid combination, composition used in peritoneal dialysis and method for performing peritoneal dialysis. Background technique [0002] Peritoneal dialysis is a dialysis method using the peritoneum as a dialysis membrane, and is a therapy for correcting body fluid abnormalities in which metabolites are moved and removed from the blood to the peritoneal dialysate in the peritoneal cavity via the peritoneum by utilizing a concentration difference (diffusion), and by osmosis Pressure differential (ultrafiltration or effluent) moves and removes excess body fluid. Currently, the mainstream therapy is CAPD (Continuous Ambulatory Peritoneal Dialysis: continuous ambulatory peritoneal dialysis) therapy. In CAPD therapy, the peritoneal dialysate is injected into the peritoneal cavity through the catheter repeatedly 3 to 5 times a day, and the fluid is drained after being stored for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/28A61K9/08A61K47/02A61K47/26A61P7/08
CPCA61K47/02A61K47/26A61P7/08A61K9/08A61M1/287A61K9/0019A61K31/7004A61K33/14
Inventor 高桥启明
Owner TERUMO KK
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