Lacrimal pineapple ketone diterpenoid compound and extraction method and application thereof

An extraction method and technology of diterpenes, which are applied in the separation/purification of carboxylic acid compounds, organic chemistry, drug combination and other directions, can solve the problems of few chemical components, unreported lung injury and depression, etc. The value of research and development, the effect of increasing the suppression level

Active Publication Date: 2020-11-10
GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The sap of the sage is a kind of herb that is very easy to grow, but there are few studies and reports on the chemical components of the sap at home and abroad, and there is no chemical composition extracted from the sap of the sap Studies have been reported for the treatment of lung injury and depression

Method used

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  • Lacrimal pineapple ketone diterpenoid compound and extraction method and application thereof
  • Lacrimal pineapple ketone diterpenoid compound and extraction method and application thereof
  • Lacrimal pineapple ketone diterpenoid compound and extraction method and application thereof

Examples

Experimental program
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Embodiment 1

[0035] Step 1. Take 7.0 kg of dried herbal medicine powder of dwarf stalks and leaves of Zhuangyao stupa and use methanol with a volume concentration of 75% to 95% to extract 3 times at room temperature for 5 days each time, filter the combined filtrate, and recover the methanol. to obtain a concentrated extract;

[0036] Step 2: Suspend the concentrated extract in water, degreasing and extract 3 times with petroleum ether and extract with a volume ratio of 1:1; the obtained aqueous layer is extracted 3 times with ethyl acetate and a water layer with a volume ratio of 1:1 , the ethyl acetate extracts were combined and concentrated to obtain 500g of thick paste;

[0037] Step 3. The volume ratio of petroleum ether to acetone for thick paste is successively 20:1, 8:1, 6:1, 4:1, 3:1, 2:1 and 1:1, and gradient elution is carried out to obtain Seven sites were numbered as Fr-A, Fr-B, Fr-C, Fr-D, Fr-E, Fr-F and Fr-G sites, and the Fr-A site was repeatedly used silica gel, dextran g...

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Abstract

The invention discloses a lacrimal pineapple ketone diterpenoid compound as well as an extraction method and application thereof. The chemical structural formula of the lacrimal pineapple ketone diterpenoid compound is shown in the specification, wherein the molecular formula of the lacrimal pineapple ketone diterpenoid compound is C18H28O4. The compound disclosed by the invention can be used forpreparing a medicine for treating acute lung injury and an anti-depression medicine.

Description

technical field [0001] The invention relates to the technical field of chemical constituents of the dwarf flesh of Zhuang medicine, in particular to a diterpenoid compound extracted from Zhuang medicine dwarf flesh, and an extraction method and application thereof. Background technique [0002] Zhuang medicine tree dwarf flesh is a commonly used medicinal material of the Zhuang people in Guangxi. Itching embolism is effective. Zhuang medicine dwarf flesh is a very easy to plant herb, but there are few researches and reports on the chemical constituents of Zhuang medicine dwarf flesh at home and abroad, and the chemical constituents extracted from Zhuang medicine dwarf flesh in the prior art are also unknown. There are reports of studies with treatments for lung injury and depression. SUMMARY OF THE INVENTION [0003] The present invention studies the chemical constituents in the dwarf flesh of Zhuang medicine, and provides a diterpenoid compound, and its chemical structu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C62/38C07C51/42A61P11/00A61P29/00A61P25/24
CPCC07C62/38A61P11/00A61P29/00A61P25/24C07C2602/28
Inventor 闫炳雄宋志军姚彩云刘喜慧吴云秋阮丽君王硕缪剑华周小雷
Owner GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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