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Use of arabinose and composition for bowel preparation

An arabinose and intestinal preparation technology, applied in the field of medicine, can solve the problems of increased intestinal mucosal permeability, large intestinal irritation, and far from achieving the preparation effect.

Active Publication Date: 2022-02-22
唐传生物科技(厦门)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Magnesium sulfate is a commonly used intestinal preparation drug recommended in clinical practice. Magnesium sulfate has the advantages of simple method and low price. However, magnesium sulfate salt is very irritating to the intestinal tract, and it is easy to cause adverse reactions such as nausea, vomiting and abdominal distension. In addition, magnesium sulfate It can change the morphology of intestinal mucosa and lead to increased permeability of intestinal mucosa, leading to intestinal mucosal damage
In addition, magnesium sulfate also has unsatisfactory bowel cleansing effect, which cannot achieve the effect of colonoscopy observation, causing patients to repeat the bowel preparation process, which not only affects the patient's psychology of bowel preparation before colonoscopy, greatly reduces the patient's compliance, and far Failure to achieve the preparation effect stated in the drug instructions will increase the medical burden of colonoscopy

Method used

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  • Use of arabinose and composition for bowel preparation
  • Use of arabinose and composition for bowel preparation
  • Use of arabinose and composition for bowel preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] This example examines intestinal preparation

[0064] Evaluation criteria for intestinal preparation:

[0065] The Ottawa score score the intestinal preparation. First, divide the colon into 3 segments (left half colon LC: rectal-ethyl colon, mid-section colon TC: cross-colon - despine saus, right semi-colon RC: liter colon and cadecin) Rating each segment. The second is to score the entire colon liquid resume. Ottawa scores put the intestinal cleanliness according to the cleaning - the worst, 0-4 points respectively. 0 is the best: the intestinal preparation is satisfactory, and the intestinal vectic residue is no, but the manure retention is not, the intestinal fluid is very clear, the operation process is smooth and the mucosa observation is good; 1 is better: intestinal preparation is comparative Satisfaction, the residue of the intestinal manure is a little, the manure retention is a little, no rinsing and attracting, the mucosa observation is basically clear, smooth o...

Embodiment 2

[0083] Explain magnesium sulfate, L-arabose on mouse excretion

[0084] experimental method

[0085] Experimental animals and their feeding: C57BL / 6J mice, non-specific pathogen free, SPF) level, male, 6 weeks old; ordinary feed is D12450-B feed: carbohydrate 67.35 wt%, crude protein 19.2% by weight, Fat 4.3 wt%. Since the temperature of the room is maintained at 24 to 26 ° C, the humidity is 40 to 60%.

[0086] Mouse constipation model construct: mice gave the lucitutamine suspension 9 mg / kg. Weight, 2 times / d, doubled, for 8 consecutive days, construct constipation rats.

[0087] Experimental examination:

[0088] Constipation mice were randomly divided into model groups, experimental groups 1, experimental groups 2 and experimental groups 3, 8 per group. In addition, 8 normal healthy non-constipation mice were randomly selected as blank control group.

[0089] The first group of mice did not help but water, then, the blank control group, the model group, the experimental ...

Embodiment 3

[0096] This example examines the intestinal mucosa damage caused by L-arabinose to improve magnesium sulfate (short simulation of large dose of magnesium sulfate intestinal preparation)

[0097] The intestinal mucosa is the maximum contact surface of the environment and the inner substance in the animal body, which not only has the function of absorbing nutrients, but also has barrier function to prevent intestinal pathogens and food antigen intrusion vectors. The intestinal mucosal barrier is used as an important composition of the body to prevent pathogens infection, preventing an important composition of inflammation, and is significant for the environmental steady state in the maintenance of the body.

[0098] The increase in intestinal mucosa permeability is an index that reflects the damage of the intestinal mucosal mechanical barrier function, which can be detected by a variety of methods, wherein the urine is the most commonly used reflection in the urine. Indicators of in...

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Abstract

The present invention relates to a use of arabinose and a composition for bowel preparation. Specifically, the present invention provides a use of arabinose for preparing a composition, and the composition is used for one or more purposes selected from the group: (i) used as a laxative; (ii) used for Intestinal preparation; (iii) for preventing and / or treating intestinal mucosal injury; (iv) for inhibiting intestinal mucosal permeability increase; (v) preventing and / or treating nausea; (vi) preventing and / or (vii) preventing and / or treating abdominal pain; and / or (viii) preventing and / or treating side effects of oral magnesium sulfate.

Description

Technical field [0001] The present invention relates to the field of pharmaceutical, and more particularly to a propylene sugar, and a composition for intestinal preparation. Background technique [0002] With the development of endoscopy, colonoscopy is widely used in clinical use, which has become one of the main means of diagnosis and treatment of various intestinal diseases. The colonoscopy examination is affected to some extent, and it is extremely important to improve the superior intestinal preparation before surgery to increase the quality of colonoscopy to increase the detection rate of colon disease. [0003] Intestinal preparation refers to a method of removing the intestinal manure by oral laxative or enema, reducing the number of bacteria in the intestine and postoperative complications. The intestinal preparation is widely used in intestinal surgery, colonoscopy, small colonoscopy, capsule, diagnosis and imaging examination, is the key to the success of colonoscopy ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7004A61K33/06A61P1/10A61P1/08A61P1/00A23L33/125A23L33/16
CPCA61K31/7004A61K33/06A61P1/10A61P1/08A61P1/00A23L33/125A23L33/16A23V2002/00
Inventor 石国良林卫军陈旭王羽娟蔡许彬萧舜之
Owner 唐传生物科技(厦门)有限公司
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