DNA methylation detection kit for evaluating tissue immune response and diagnosis prognosis
A technology of methylation and prognosis, applied in medical and biological fields
Active Publication Date: 2021-01-12
THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV +1
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Meanwhile, immunotherapy for CRC remains challenging due to the heterogeneity of its immune response 7，8
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[0050] The technical scheme of the present invention is further described below in conjunction with experiments.
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The invention discloses a DNA methylation detection kit for evaluating tissue immune response and diagnosis prognosis. The inventor finds that at least one of CpG loci cg02430840, cg06113913 and cg12673499 can be used for reliably evaluating the tissue immune response and diagnosis prognosis, especially the level of CD8+TILs in CRC and the prognosis of the CD8+TILs. The DNA methylation detection kit is expected to become a research tool of the CD8+TILs and become a potential marker for guiding immunotherapy of colorectal cancer and other cancers.
Description
technical field [0001] The invention relates to the medical and biological fields, in particular to DMPs that can be used to determine tissue immune responses, especially the abundance of CD8+ T cells in tumor samples, and applications thereof. Background technique [0002] Tumor-infiltrating lymphocytes (TILs) correlate with tumor immune responses and can be used to predict immunotherapy response and survival outcomes 9-11 , in which CD8+ TILs rely on cytotoxicity to kill cancer cells and affect the prognosis, immunotherapy response and survival outcomes of CRC 12-14 . Including recommendations from the International TILs Working Group 15 and immune score 16 Various morphological-based methods for assessing TILs levels have been established and widely validated. [0003] The current evaluation of CD8+ TILs relies on histopathological methods, which are cumbersome and poorly reproducible, and have certain limitations. Some markers based on gene expression such as CD8B a...
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IPC IPC(8): C12Q1/6886C12Q1/6883G16B20/20G16B20/30G16B25/20G16B40/30G16B45/00
CPCC12Q1/6886C12Q1/6883G16B20/20G16B20/30G16B25/20G16B40/30G16B45/00C12Q2600/154C12Q2600/118
Inventor 禹汇川骆衍新邹齐王小琳申鼎成任东林唐冠楠张宇黄美近
Owner THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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