A rare earth-mxene two-dimensional material for immune-photodynamic synergistic therapy and its preparation method and application

A two-dimensional material and photodynamic technology, applied in the field of MXene materials, to achieve good effect, high utilization rate, and large load density

Active Publication Date: 2022-03-18
XIDIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both photodynamic therapy and immunotherapy are new and effective means of cancer treatment, but the combination of photodynamic therapy and immunotherapy to produce synergistic treatment of cancer cells has not yet appeared.

Method used

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  • A rare earth-mxene two-dimensional material for immune-photodynamic synergistic therapy and its preparation method and application
  • A rare earth-mxene two-dimensional material for immune-photodynamic synergistic therapy and its preparation method and application
  • A rare earth-mxene two-dimensional material for immune-photodynamic synergistic therapy and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0021] Method for preparing a rare earth-MXENE two-dimensional material for immunoharmaceutically synergistic treatment, the specific method is: the above UCNPS @ Ti 3 C 2 The preparation method is: First, use HCl + LIF to Ti 3 ALC 2 Erregation prepared multi-layered Ti 3 C 2 The specific practice is: preparing 20 mL of HCl (9 mol / L), then add 2 g LIF and 2 g Ti with stirring 3 ALC 2 To prevent excessive exotherm of the reaction to prevent the reaction. This etching process needs to be held for a whole 24 hours at 35 ° C. Thereafter, clean with ultrapure water until the pH of the solution rose to 7.5. Use ultrapure water to etch Ti 3 ALC 2 The solution was diluted into 300 mL solution and filled with nitrogen for 55 minutes. Finally, the product after centrifug is lyophilized, get the required Ti 3 C 2. Good ethanol protects Ti 3 C 2 Not oxidized, therefore, 20 mg of multi-layer Ti needed 3 C 2 Soluble in 4 ml of ethanol, and to get thinner Ti in ultrasound 1 h 3 C 2 For subsequ...

Embodiment 2

[0024] Method for preparing a two-dimensional material for immuno - photodynamic synergistic treatment, the specific method is:

[0025] UCNPS @ Ti 3 C 2 The preparation method is: First, use HCl + LIF to Ti 3 ALC 2 Erregation prepared multi-layered Ti 3 C 2 The specific practice is: Prepare 20 mL of HCl (9 mol / L), then add 2 g LIF and 2 GTI with 2 GTi with stirring 3 ALC 2 To prevent excessive exotherm of the reaction to prevent the reaction. This etching process needs to be held at 37 ° C for 24 hours. Thereafter, the washed with ultrapure water until the pH of the solution was increased to 6.5. Use ultrapure water to etch Ti 3 ALC 2 The solution was diluted into 300 mL solution and filled with nitrogen for 65 minutes. Finally, the product after centrifug is lyophilized, get the required Ti 3 C 2 . Good ethanol protects Ti 3 C 2 Not oxidized, therefore, 20 mg of multi-layer Ti needed 3 C 2 Soluble in 4 ml of ethanol, and more than 55 minutes to get thinner Ti 3 C 2 For subsequ...

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Abstract

A preparation method of rare earth-Mxene two-dimensional materials for immune-photodynamic synergistic therapy, (1) First, use HCL+LiF to treat Ti 3 AlC 2 Etching to prepare multilayer Ti 3 C 2 ; (2) At the same time, use the hydrothermal method to synthesize NaYF 4 : Yb, Tm upconversion nanoparticles UCNPs, Tm 3+ Up-conversion nanoparticles UCNPs will emit ultraviolet light under the excitation of near-infrared light NIR; (3) Finally, the multilayer Ti 3 C 2 Synthesis of UCNPs@Ti with UCNPs under the action of electrostatic adsorption 3 C 2 composite material. The selected two-dimensional material Ti of the present invention 3 C 2 It has a narrow band gap, so it has a large light absorption range and a high utilization rate of incident light. At the same time, Ti 3 C 2 With the ability to absorb ultraviolet light, it can bind UCNPs to respond to its emitted light. The present invention combines UCNPs up-converting nanoparticles, so the advantages of near-infrared excitation light can be utilized. The present invention combines immunotherapy on the basis of photodynamic therapy, and has better effect than single photodynamic therapy.

Description

Technical field [0001] The present invention relates to the field of MXENE material, and more particularly to a rare earth-MXENE two-dimensional material for immuno-photodynamic synergistic treatment and a preparation method and application thereof. Background technique [0002] In recent years, the photodynamic therapy PDT has been a new tumor treatment method, and there are many advantages compared with traditional treatment methods: non-invasive, side effects, short treatment time, accurate target positioning and repeatability. Tumor immunotherapy is also a new tumor treatment after traditional surgery, chemotherapy, and radiotherapy. Due to its high specificity, the efficacy is remarkable, causing the attention of scholars. Photodynamic therapy and immunotherapy are new effective means of treatment of cancer, but currently in combination of photodynamic therapy and immunotherapy is currently in combination of cancer cells. In 2011, MXENE materials were found to be a new hotsp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K39/395A61P35/00C01F17/36C01F17/10B82Y40/00C01B32/921B82Y30/00B82Y20/00C09K11/85C09K11/02
CPCA61K41/0057C07K16/2827A61P35/00C01F17/36C01F17/10B82Y40/00B82Y30/00B82Y20/00C01B32/921C09K11/7773C09K11/025A61K2039/505A61K2039/585C01P2006/60C01P2004/80C01P2004/04A61K2300/00
Inventor 吕锐婵吴巍炜杨凡屈丹瑶郭力豪袁苗苗田捷
Owner XIDIAN UNIV
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