Biological ink, preparation method and application thereof, abdominal wall repair patch stent and preparation method of abdominal wall repair patch stent

A technology of bio-ink and abdominal wall, applied in the direction of tissue regeneration, medical science, prosthesis, etc., to achieve the effect of good mechanical properties

Active Publication Date: 2021-02-12
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Excellent biocompatibility is a necessary condition for bio-inks, but it is difficult for single-material bi...

Method used

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  • Biological ink, preparation method and application thereof, abdominal wall repair patch stent and preparation method of abdominal wall repair patch stent
  • Biological ink, preparation method and application thereof, abdominal wall repair patch stent and preparation method of abdominal wall repair patch stent

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preparation example Construction

[0031] The present invention provides a method for preparing the bio-ink described in the above scheme, comprising the following steps: dissolving the polymer in a solvent to obtain a polymer solution; the polymer includes thermoplastic polyurethane, polylactic acid or polycaprolactone;

[0032] The polymer solution and aloe vera powder were mixed to obtain a bio-ink.

[0033] In the present invention, unless otherwise specified, the raw materials used are commercially available products well known in the art.

[0034] In the invention, the polymer is dissolved in a solvent to obtain a polymer solution. In the present invention, the polymer includes thermoplastic polyurethane, polylactic acid or polycaprolactone. In the present invention, the solvent corresponds to the solvent that can dissolve the polymer in the bio-ink described in the above scheme, and will not be repeated here. In the present invention, the polymer solution is a colloidal solution.

[0035] After obtain...

Embodiment 1

[0059] Prepare the patch support for abdominal wall repair, and the specific preparation steps are as follows:

[0060] a. Bioink preparation:

[0061] Weigh 7.2±0.03g of thermoplastic polyurethane particles into a beaker, add dimethylamide solution, and stir for 2 hours with a magnetic stirrer to obtain a polyurethane solution (concentration: 0.8g / mL);

[0062] Weigh the aloe powder and grind it (the mesh number is greater than 500 mesh), then mix the aloe powder with the polyurethane solution, and use a magnetic stirrer to stir the solution for 2 hours to prepare the bioink (wherein the concentration of the aloe powder is 1.0g / mL) ;

[0063] b. Dip coating mold structure:

[0064] like figure 1 As shown, the dip-coating mold used includes two parts: the mold base and the upper mold. The mold is designed according to the abdominal wall patch structure. There are evenly distributed vertical columns on the base structure. The designed height of the columns is 3±0.1mm. The d...

Embodiment 2

[0074] A method for preparing a patch support for abdominal wall repair, comprising the steps of:

[0075] a. Printing ink preparation:

[0076] Weigh a set amount of polylactic acid particles and add them to a beaker, add dichloromethane solution, use a magnetic stirrer to mix the mixed solution evenly, and prepare a polylactic acid colloidal solution;

[0077] Take by weighing aloe powder and grind (mesh number is greater than 500 orders), then aloe powder is mixed with polylactic acid colloidal solution, uses magnetic stirrer to carry out 2 hours stirring to solution, makes biological ink (wherein, the concentration of aloe powder is 1.25g / mL);

[0078] B. Dip coating mold structure: same as embodiment 1;

[0079] c. Pre-stent printing:

[0080] The biological ink prepared in step a is added in the medical needle tube of 25G needle;

[0081] Then install the needle tube on the X motion axis of the electrohydrodynamic jet printer, and input the programmed G code into th...

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Abstract

The invention provides biological ink, a preparation method and an application thereof, an abdominal wall repair patch stent and a preparation method thereof, and belongs to the technical field of tissue engineering. The biological ink comprises a polymer, a solvent capable of dissolving the polymer and aloe powder, wherein the polymer comprises thermoplastic polyurethane, polylactic acid or polycaprolactone. The biological ink disclosed by the invention contains the polymer, the polymer has good mechanical properties and biocompatibility, and by adding the aloe powder, the biocompatibility ofthe biological ink can be improved; and various anti-inflammatory and regeneration-promoting components contained in aloe can be fully utilized to effectively avoid inflammatory infection at wounds,improve the growth and propagation capacity of damaged cells and enhance the antibacterial and growth-promoting capacities of the biological ink, thereby making up for the performance defects of the existing single-material biological ink. The biological ink disclosed by the invention is used for preparing the biological stent, and the obtained biological stent has good mechanical properties, biocompatibility and biological regenerability.

Description

technical field [0001] The invention relates to the technical field of tissue engineering, in particular to a bio-ink, a preparation method and application thereof, an abdominal wall repair patch bracket and a preparation method thereof. Background technique [0002] In recent years, the rise of 3D printing has attracted the attention of various industries. Among them, the use of bio-3D printing technology to prepare various tissue engineering scaffolds is the focus of research in the fields of additive manufacturing, life sciences, and medical health. The rapid development of bio-3D printing has also shown its shortcomings, among which the bio-ink used in printing has the greatest impact on the performance of tissue engineering scaffolds. Excellent biocompatibility is a necessary condition for bio-inks, but it is difficult for a single-material bio-ink to meet the requirements of biocompatibility, bioreproducibility, and mechanical properties at the same time. Contents of...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/36A61L27/50A61L27/56
CPCA61L27/18A61L27/3637A61L27/56A61L27/50A61L2300/30A61L2300/412A61L2300/41A61L2430/00C08L67/04C08L75/04
Inventor 胡庆夕巫俊杰张海光
Owner SHANGHAI UNIV
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