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Chiral detection system

A detection system and chiral technology, which is applied in the field of chiral detection systems, can solve problems such as low detection efficiency and equipment incompatibility, and achieve the effects of reducing detection time, expanding range, and improving detection efficiency

Active Publication Date: 2021-02-19
SHANGHAI JIAO TONG UNIV
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Problems solved by technology

[0005] The purpose of the present invention is to provide a chiral detection system, which can simultaneously perform three-dimensional imaging and chiral detection of chiral substances in the same system, so as to efficiently obtain the chiral structure and chiral strength information of the sample to solve the current problem. There are problems such as equipment incompatibility and low detection efficiency in the technology

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Embodiment Construction

[0022] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0023] figure 1 Schematic diagram of the structure of the chiral detection system. The composition of the system includes: a first laser 1, a first attenuation plate 2, a first polarizer 3, beam splitters 4, 22, 27, half-wave plates 5, 10, 26, converging lenses 6, 11, and an aperture 7 , 12, beam expander lens 8, 13, reflecting mirror 9, 14, 25, first polarizing beam splitter 15, first quarter-wave plate 16, dichroic mirror 17, 21, microscope objective lens 18, load stage 19, condenser lens 20, optical filters 23, 28, photodetectors 24, 29, computer 30 and chiral detection module 31.

[0024] figure 2 The transmission mode light path diagram of the chiral detection system. The optical path includes: a reference optical branch 32 and an object optical branch 33 .

[0025] Figure 4Schematic diagram of the structure of the chiral detection...

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Abstract

The invention relates to a chiral detection system. The chiral detection system comprises a tomography module and a chiral detection module, the tomography module and the chiral detection module sharethe following structures which are connected in sequence: a first dichroscope, a microscope objective lens, an objective table, a collecting lens and a second dichroscope; the chiral detection systemis divided into a transmission mode and a reflection mode. When a sample is a transparent sample, the chiral detection system is set to be in a transmission mode, and when the sample is a turbid sample, the chiral detection system is set to be in a reflection mode. According to the chiral detection system, three-dimensional imaging and chiral detection of a chiral sample can be carried out in thesame system at the same time, and the chiral structure and chiral strength information of the sample are obtained while the detection time is shortened and the detection cost is reduced.

Description

technical field [0001] The invention relates to a chiral detection system, which belongs to the technical field of chiral detection. Background technique [0002] As a current research hotspot, chirality has attracted extensive attention of researchers. Chiral molecules, chiral drugs and chiral materials play an extremely important role in many fields such as chemistry, biology, medicine, pharmacy, and materials science. The material properties or medical applicability of many substances depend on chirality, and many biological processes are related to chirality, such as: molecular recognition, metabolic reactions, enzyme-catalyzed reactions, etc. Therefore, it is of great significance to develop corresponding imaging and detection technologies to detect the chirality of substances. [0003] First of all, optical imaging has important application value in the field of chiral structure detection due to its non-destructive testing characteristics. In order to improve the det...

Claims

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Application Information

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IPC IPC(8): G01N21/19G01N21/21
CPCG01N21/19G01N21/21
Inventor 吕子瑶王长顺
Owner SHANGHAI JIAO TONG UNIV
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