Venlafaxine sustained-release capsule composition and preparation process thereof
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A technology of sustained-release capsules and venlafaxine, which is applied in the field of medicine and can solve problems such as complex structure of coating devices, increased costs, and complex ingredients of antidepressants
Pending Publication Date: 2021-02-26
HAINAN WEI KANG PHARMA QIANSHAN
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[0007] The antidepressant drugs in the prior art have complex components and high requirements on the production equipment, which greatly increases the pro
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Embodiment 1
[0054] Composition of drug-containing pill core: Venlafaxine hydrochloride 34.8%, microcrystalline cellulose 58%, hydroxypropyl methylcellulose 0.53%, sustained-release coating components (5.5%) including ethyl cellulose and hydroxypropyl methylcellulose Cellulose, ethanol.
[0055] The preparation method is:
[0056] (1) Venlafaxine hydrochloride and microcrystalline cellulose are mixed;
[0057] (2) adding a mixed aqueous solution of hydroxypropylmethylcellulose to the resulting mixture;
[0058] (3) Extrude, spheronize, and dry to obtain a pill core;
[0059] (4) Coating the pill core with a coating solution to obtain sustained-release pellets;
[0060] (5) Put the sustained-release pellets into hollow capsules to obtain venlafaxine hydrochloride sustained-release capsules.
[0061] The sustained-release capsules have a specification of 150mg.
[0065] (1) Venlafaxine hydrochloride and microcrystalline cellulose are mixed;
[0066] (2) adding a mixed aqueous solution of hydroxypropylmethylcellulose to the resulting mixture;
[0067] (3) Extrude, spheronize, and dry to obtain a pill core;
[0068] (4) Coating the pill core with a coating solution to obtain sustained-release pellets;
[0069] (5) Put the sustained-release pellets into hollow capsules to obtain venlafaxine hydrochloride sustained-release capsules.
[0070] The sustained-release capsules have a specification of 150mg.
[0071] Such as Figure 1 to Figure 6 As shown, the coating device includes a feeding mechanism 1 and a coating mechanism 2, the feeding mecha...
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Abstract
The invention discloses a venlafaxine sustained-release capsule composition and a preparation process thereof. The composition comprises a hollow capsule and a sustained-release pellet in a hollow capsule shell, wherein the sustained-release pellet is composed of a drug-containing pellet core and a sustained-release coating, the drug-containing pellet core comprises venlafaxine hydrochloride, microcrystalline cellulose and hydroxypropyl methyl cellulose, and the sustained-release coating comprises ethyl cellulose and hydroxypropyl methyl cellulose. The invention further provides a preparationmethod of the capsule. The method is simple in process, mild in condition, simple in preparation, few in auxiliary material variety and dosage, low in equipment requirement and suitable for industrialproduction. The invention further discloses a coating device. Venturi tube design is adopted in a forming and separating device of the coating device, materials input from a solid-phase feeding holeare impacted, drug particles adhering after coating are separated, the coating on the surfaces of the particles can be cooled and cured through low-temperature nitrogen, and the situation that the drug particles adhere again subsequently, and consequently drug processing is affected is avoided.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a venlafaxine sustained-release capsule composition and a preparation process thereof. Background technique [0002] Depression is one of the serious mental illnesses with high prevalence, high relapse rate, high disease burden and high autologous mortality. It is a group of mood disorders or affective disorders caused by various reasons, with depression as the main symptom, and a group of clinical symptoms centered on depressed mood and self-situation. At present, traditional Chinese medicine mainly treats depression by invigorating the kidney, soothing the liver and relieving depression, and regulating the balance of yin and yang, but there is still a lack of basic research to clarify its mechanism of action, and there is still a lack of objective and standardized research on how to differentiate depression. Western medicine mostly adopts drug therapy, such as ant...
Claims
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