Judgment method and device for evaluating human gene function feasibility by zebra fish model

Abstract

The invention provides a method and device for evaluating human gene function feasibility through zebra fish models, and the method comprises the steps: building a corresponding first neural network according to different gene models, and enabling an evaluation result of the gene models to serve as the output of the corresponding first neural network, wherein input nodes of the first neural network are in one-to-one correspondence with gene evaluation items, and the gene evaluation items comprise human CDS sequence length, zebra fish homologous genes, zebra fish homologous gene sequence integrity, protein sequence alignment, expression conditions of the genes in the zebra fish embryo stage, pLI scores, research of the genes in zebra fish and research of the genes in organisms of other models; and evaluating the zebra fish model evaluation human gene function by using the first neural network, and obtaining an evaluation result. The method is quick and accurate, and can replace manual work to quickly obtain a feasibility evaluation result.

Description

technical field [0001] The invention relates to the field of genes, in particular to evaluating the feasibility of human gene functions in a zebrafish model. Background technique [0002] With the rise of research on the model organism zebrafish, more and more scholars use the zebrafish model to explore genes related to the occurrence of diseases, but there is currently no systematic evaluation method for the feasibility of using the zebrafish model to evaluate human gene functions. It needs to rely on the judgment of experienced professionals, and it is very dependent on experience. Once the judgment is wrong, it will lead to a lot of waste of manpower and resources if it encounters obstacles in later investment in research. [0003] The cultivation of professionals who meet the above-mentioned experience requirements requires more theoretical and practical learning. At present, there is a huge gap between this type of personnel and the task load of the job. Moreover, with...

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Problems solved by technology

[0005] The purpose of the present invention is to provide a method for judging the feasibility of a zebrafish model to evaluate the function of human genes, which is used to solve the technical problem that the above-mentioned feasibility judgment is extremely dependent on manual experience

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