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The method and device of the zebra fish model evaluating the feasibility of human gene function

A model evaluation, gene function technology, applied in the field of genes, can solve the problem of feasibility judgment relying on artificial experience and so on

Active Publication Date: 2022-08-09
SUZHOU SMK GENE TECH LTD
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  • Abstract
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Problems solved by technology

[0005] The purpose of the present invention is to provide a method for judging the feasibility of a zebrafish model to evaluate the function of human genes, which is used to solve the technical problem that the above-mentioned feasibility judgment is extremely dependent on manual experience

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  • The method and device of the zebra fish model evaluating the feasibility of human gene function

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Embodiment 2

[0077] Based on the same inventive concept as the method for judging the feasibility of evaluating human gene function in a zebrafish model in the foregoing embodiment, the present invention also provides an exemplary electronic device, including a memory, a processor, and an electronic device stored on the memory and available in the memory. A computer program running on a processor, when executing the program, the processor implements the steps of a method for judging the feasibility of evaluating human gene function for a zebrafish model.

[0078] The above-mentioned one or more technical solutions in the embodiments of the present application have at least one or more of the following technical effects: the feasibility of evaluating human gene function in the zebrafish model can be quickly and accurately judged, which is basically the same as the result of manual evaluation. Consistent.

[0079] As will be appreciated by one skilled in the art, embodiments of the present i...

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Abstract

The present invention provides a method and a device for evaluating the feasibility of human gene function by a zebrafish model, constructing a corresponding first neural network according to different gene models, and using the evaluation result of the gene model as the output of the corresponding first neural network; The input nodes of a neural network correspond one-to-one with a gene evaluation item, the gene evaluation item includes the length of human CDS sequence, zebrafish homologous gene, zebrafish homologous gene sequence integrity, protein sequence alignment, gene in zebra Expression of fish embryos, pLI score, gene research in zebrafish, gene research in other model organisms; use the first neural network to evaluate the function of human genes in the zebrafish model, and obtain the evaluation results. The above method is fast and accurate, and can quickly obtain feasibility evaluation results instead of manual work.

Description

technical field [0001] The present invention relates to the field of genes, in particular to the feasibility of evaluating human gene function in a zebrafish model. Background technique [0002] With the rise of model organism zebrafish research, more and more scholars use zebrafish models to explore genes related to disease occurrence. However, there is currently no systematic evaluation method for the feasibility of using zebrafish models to evaluate human gene function. It is necessary to rely on the judgment of experienced professionals, and the dependence on experience is very strong. Once the judgment is wrong, the later investment in research will be hindered, which will lead to a lot of waste of manpower and resources. [0003] The training of professionals who meet the above-mentioned experience requirements requires a lot of theoretical and practical learning. At present, such personnel have a great gap compared with the workload of the work. Moreover, with the co...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B20/30G16B30/10G16B5/00G06N3/08G06N3/04
CPCG16B20/30G16B30/10G16B5/00G06N3/08G06N3/045Y02A40/81
Inventor 刘静刘乐余伟师梁萌萌王小冬叶鑫
Owner SUZHOU SMK GENE TECH LTD