Medical absorbable burn and scald repair film and preparation method thereof

A technology for burns and casings, applied in the field of biomedicine, can solve the problems of rough pigskin cortex, impact on wound healing, and inability to completely remove it, and achieve the effects of small tissue adverse reactions, accelerated wound healing, and less bacterial contamination

Inactive Publication Date: 2021-03-16
山东康利达医用制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although pigskin biological dressings are easy to obtain, the impurities and fats in the cortex cannot be completely removed, and the pigskin cortex is rough, with poor air permeability, and the thickness error after processing into dressings is relatively large. Scars, local keratinization, and individual patients have skin edema and congestion, which have a greater impact on the healing of wounds on the face and neck

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of a medical absorbable burn and scald repair film of this embodiment, the preparation method is carried out as follows:

[0025] (1) Select the casings that have passed the quarantine and cut off the small intestine;

[0026] (2) Remove impurities: clean the inner wall of the casing of the small intestine, and separate and shed the intestinal chorion, mucous membrane, and serosa in the casing with special equipment;

[0027] (3) Virus inactivation: Soak the casing from which impurities have been removed in a 4% edible hydrogen peroxide solution at a water temperature of 37°C for 10 hours, and then wash it three times with purified water.

[0028] (4) Collagen degreasing: clean the above-mentioned sausage casing with clean water, soak it in 8% sodium chloride solution for 55 minutes, and then separate and remove the fat in the collagen of the casing to obtain relatively pure collagen tissue;

[0029] (5) Casing extension: After cutting the casing i...

Embodiment 2

[0036] A preparation method of a medical absorbable burn and scald repair film of this embodiment, the preparation method is carried out as follows:

[0037] (1) Select the casings that have passed the quarantine and cut off the small intestine;

[0038] (2) Remove impurities: clean the inner wall of the casing of the small intestine, and separate and shed the intestinal chorion, mucous membrane, and serosa in the casing with special equipment;

[0039] (3) Virus inactivation: Soak the casing from which impurities have been removed in a 5% edible hydrogen peroxide solution at a water temperature of 38°C for 12 hours, and then wash it 4 times with purified water.

[0040] (4) Collagen degreasing: clean the above casing with water, put it into 10% sodium chloride solution and soak for 60 minutes, then separate and remove the fat in the collagen of the casing to obtain relatively pure collagen tissue;

[0041] (5) Casing extension: After cutting the casing into pieces, use the e...

Embodiment 3

[0048] A preparation method of a medical absorbable burn and scald repair film of this embodiment, the preparation method is carried out as follows:

[0049] (1) Select the casings that have passed the quarantine and cut off the small intestine;

[0050](2) Remove impurities: clean the inner wall of the casing of the small intestine, and separate and shed the intestinal chorion, mucous membrane, and serosa in the casing with special equipment;

[0051] (3) Virus inactivation: Soak the casing from which impurities have been removed in an edible hydrogen peroxide solution with a water temperature of 39°C and a concentration of 6% for 14 hours, then wash it 5 times with purified water.

[0052] (4) Collagen degreasing: clean the above-mentioned sausage casing with clean water, soak it in 12% sodium chloride solution for 65 minutes, then separate and remove the fat in the collagen of the casing to obtain relatively pure collagen tissue;

[0053] (5) Casing extension: After cuttin...

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PUM

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Abstract

The invention discloses a medical absorbable burn and scald repair film and a preparation method thereof. The preparation method comprises the steps of material selection, heteropolymeric protein removal, virus inactivation, collagen degreasing, casing extension, chitosan atomization, dressing shaping, dressing solidification, cutting and inspection, packaging, sterilization and the like. Chitosanhas antibacterial activity, can resist microbial infection, induce tissue regeneration and accelerate wound healing, and does not cause any inflammatory reaction in tissue. Collagen has hemostatic and repairing functions, has bioabsorbability and cell adhesion, and can promote new cell formation and epithelial cell formation. The medical absorbable burn and scald repair film is low in antigenicity, and good in human tissue compatibility, is stable in absorption period through automatic coordination and absorption of enzymes and body fluid, and finally, is absorbed by a human body completely.The burn and scald repair film prepared by the method has the characteristics of uniform texture, good elasticity, high transparency, good air permeability, good biocompatibility, capability of beingabsorbed by organisms, small toxic and side effects and the like.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a medical absorbable burn repair film and a preparation method thereof. Background technique [0002] Medical absorbable burn and scald repair film belongs to the biological dressings in the category of infusion, nursing and protective equipment in the classification of medical devices. Currently, the existing burn repair dressings on the market are mainly pigskin biological dressings and heterogeneous acellular dermal matrix dressings. my country Pigskin biological dressings are widely used. However, although pigskin biological dressings are easy to obtain, the impurities and fats in the cortex cannot be completely removed, and the pigskin cortex is rough, with poor air permeability, and the thickness error after processing into dressings is relatively large. Scars, local keratinization, and individual patients have skin edema and congestion, which have a greater impact on t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0033A61L26/0057A61L26/0066A61L26/009A61L2300/232A61L2300/252A61L2300/404A61L2300/412C08L89/00C08L5/08
Inventor 王桂发王亚群
Owner 山东康利达医用制品有限公司
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