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Composition containing umbilical cord mesenchymal stem cell exosomes and application thereof

A technology of mesenchymal stem cells and exosomes, applied in the field of biotechnology, can solve the problems of thinning of the cuticle of the facial skin, prone to allergies, redness and damage, etc., to increase skin elasticity and plumpness, restore anti-oxidation and regeneration Ability, the effect of repairing the skin's own barrier function

Pending Publication Date: 2021-03-19
广州美邦生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the excessive use of cosmetics, many people have thinned facial skin stratum corneum, prone to symptoms such as allergies, redness, and damage

Method used

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  • Composition containing umbilical cord mesenchymal stem cell exosomes and application thereof
  • Composition containing umbilical cord mesenchymal stem cell exosomes and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Umbilical cord mesenchymal stem cell exosomes: 0.02%;

[0034] Anthocyanins: 0.5%; Resveratrol: 0.5%; Vitamin E: 0.5%; Carotenoids: 0.5%;

[0035] Artemisia polysaccharide: 0.6%; Undaria pinnatifida polysaccharide: 0.6%; Sargassum polysaccharide: 0.6%;

[0036] Sodium Hyaluronate: 2.0%; Glycerin: 2.5%; Glycine: 2.0%; Arginine: 2.5%;

[0037] Niacinamide: 0.3%; Hydroxyethylcellulose: 0.3%; Ceramide-2: 0.2%;

[0038] Deionized water: balance.

[0039] The preparation method of the above-mentioned umbilical cord mesenchymal stem cell exosomes comprises the following steps:

[0040] (1) Take a fresh umbilical cord, cut the umbilical cord into small pieces under aseptic conditions, wash it with PBS buffer repeatedly 3 times, remove the arteries and veins to obtain Wharton's gum, cut Wharton's gum into pieces and add collagenase digestion solution Carry out digestion; mix the digested suspension evenly, dilute it with PBS until it is not viscous, filter it with a cell str...

Embodiment 2

[0046] Umbilical cord mesenchymal stem cell exosomes: 0.02%;

[0047] Anthocyanins: 0.5%; Resveratrol: 0.5%; Vitamin E: 0.5%; Carotenoids: 0.5%;

[0048] Centella asiatica extract: 1.5%; Purslane extract: 1.5%;

[0049] Artemisia polysaccharide: 0.6%; Undaria pinnatifida polysaccharide: 0.6%; Sargassum polysaccharide: 0.6%;

[0050] Sodium Hyaluronate: 2.0%; Glycerin: 2.5%; Glycine: 2.0%; Arginine: 2.5%;

[0051] Niacinamide: 0.3%; Hydroxyethylcellulose: 0.3%; Ceramide-2: 0.2%;

[0052] Deionized water: balance.

[0053] The preparation method of umbilical cord mesenchymal stem cell exosomes and composition is the same as that of Example 1.

Embodiment 3

[0055] Umbilical cord mesenchymal stem cell exosomes: 0.3%;

[0056]Anthocyanins: 0.8%; Resveratrol: 0.5%; Vitamin E: 0.8%; Carotenoids: 0.5%;

[0057] Centella asiatica extract: 1.5%; Purslane extract: 1.5%;

[0058] Artemisia polysaccharide: 0.5%; Undaria pinnatifida polysaccharide: 0.8%; Sargassum polysaccharide: 0.7%;

[0059] Sodium Hyaluronate: 2.5%; Glycerin: 2.5%; Glycine: 2.5%; Arginine: 2.5%;

[0060] Niacinamide: 0.4%; Hydroxyethylcellulose: 0.4%; Ceramide-2: 0.4%;

[0061] Deionized water: balance.

[0062] The preparation method of umbilical cord mesenchymal stem cell exosomes and composition is the same as that of Example 1.

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Abstract

The invention relates to a composition containing umbilical cord mesenchymal stem cell exosomes. The composition comprises the following components in percentage by mass: 0.02-0.6% of the umbilical cord mesenchymal stem cell exosomes, 2.5-5.0% of an antioxidant, 1.5-2.5% of algal polysaccharides, 5.6-12.5% of a humectant, 0.05-0.6% of nicotinamide, 0.2-0.8% of hydroxyethyl cellulose, 0.1-0.5% of ceramide-2,, and the balance of deionized water. According to the composition, on the basis of adding the umbilical cord mesenchymal stem cell exosomes, the humectant, the antioxidant and the algal polysaccharides are matched, so that metabolism of skin cells can be accelerated, oxidation resistance and regeneration capacity of basal cells can be recovered, skin aging can be prevented, skin elasticity and plumpness can be increased, pores can be shrunk, and gloss can be improved.

Description

technical field [0001] The invention relates to the technical field of biotechnology, more specifically, it relates to a composition containing exosomes of umbilical cord mesenchymal stem cells and its application. Background technique [0002] The skin covers the surface of the body. As the first natural barrier, it directly contacts the outside world and can prevent external stimuli such as microbial invasion and ultraviolet damage. However, with the excessive use of cosmetics, many people have thinned facial skin stratum corneum, prone to symptoms such as allergies, redness, and damage. [0003] Stem cell therapy has shown great potential in the field of regenerative medicine, especially umbilical cord mesenchymal stem cells; due to its wide range of sources, convenient extraction, and low immunogenicity, it has attracted more and more attention. [0004] However, the current umbilical cord mesenchymal stem cells are mostly used to treat autoimmune diseases such as lupus...

Claims

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Application Information

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IPC IPC(8): A61K8/99A61K8/9789A61K8/73A61K8/34A61K8/44A61K8/67A61K8/68A61Q19/00A61Q19/08
CPCA61K8/99A61K8/73A61K8/731A61K8/68A61K8/675A61K8/9789A61K8/735A61K8/44A61K8/345A61Q19/00A61Q19/08A61K2800/72
Inventor 董剑波许敏玲
Owner 广州美邦生物科技有限公司
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