Individualized target positioning method based on weight function connection

A positioning method and functional technology, applied in the field of medical imaging, can solve problems such as stimulation of a single brain area, inability to stimulate deep brain tissue, and lack of therapeutic effectiveness

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A positioning method and functional technology, applied in the field of medical imaging, can solve problems such as stimulation of a single brain area, inability to stimulate deep brain tissue, and lack of therapeutic effectiveness

CN112546446APending Publication Date: 2021-03-26THE AFFILIATED SIR RUN RUN SHAW HOSPITAL OF SCHOOL OF MEDICINE ZHEJIANG UNIV

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[0036] Example: such as figure 1 as shown,

[0037] Step S1. Select suitable patients for magnetic resonance scanning: In this embodiment, select suitable patients with Alzheimer's disease to enroll in the group, and perform structural magnetic resonance and resting-state functional magnetic resonance scanning on the patients; instruct the patients to keep quiet during the scanning process Awake and head still, tell the patient to keep eyes open and watch the computer screen during the resting state functional magnetic resonance scan; structural magnetic resonance 3D-T1 scan.

[0038]Step S2, based on cognitive function-related scales (such as the Mini-Mental State Evaluation Scale (MMSE)) score, the Mini-Mental State Evaluation Scale (MMSE) is shown in Table 1, and the weight estimation is performed, such as (orientation 10 Points, memory, 3 points, attention 3 points, language 6 points, (Note: The full score of this scale is 30 points, respectively, orientation is 10 points...

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Abstract

The invention discloses an individualized target positioning method based on weight function connection. The method comprises the following steps: S1, performing structural magnetic resonance and resting-state functional magnetic resonance scanning on a patient without magnetic resonance contraindication to obtain structural magnetic resonance and resting-state functional magnetic resonance data;S2, carrying out scale evaluation of mild cognitive impairment on the patient, and determining scores of different dimensions of a scale; S3, preprocessing the resting-state functional magnetic resonance data; S4, determining a deep brain region and a surface contact brain region which need to be intervened; and S5, in combination with the score of the cognitive assessment scale, calculating the maximum weight function connection of the functional connection between the deep brain region related to cognition and the brain region of interest, and determining the point of the brain region of interest corresponding to the maximum weight function connection as an individualized stimulation target of transcranial magnetic stimulation. The method solves the problem that repeated transcranial magnetic stimulation can only be focused on the surface of the brain and cannot stimulate deep brain tissue.

Description

technical field [0001] The invention relates to the technical field of medical imaging, in particular to an individualized target location method based on weighted functional connections. Background technique [0002] The brain regions of the human brain are not isolated, but interconnected in neural activity, and functional connectivity (FC) can describe the strength of this association. For several brain regions with strong neural activity correlations, they are usually called networks. Changes in the activity of one brain region in the network will affect the activities of other brain regions in the network, and their functions are synchronized. [0003] Transcranial magnetic stimulation is a safe, non-invasive, non-invasive intervention. Its principle is based on the electromagnetic induction effect, by applying a changing magnetic field outside the cranium to generate an induced current in the cranium, changing the membrane potential of neurons, and regulating neurons. ...

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Application Information

Patent Timeline

26 Mar 2021

Publication

CN112546446A

IPC: A61N2/00; A61B5/055

CPC: A61N2/006; A61B5/055; A61B5/0042; Y02A90/30

Inventors: 陈炜; 沈悦娣