Purpose of loganin in preparation of medicine used for preventing and treating autoimmune hepatitis

An autoimmune, logan aglycone technology is applied in the field of logan aglycone in the preparation of autoimmune hepatitis prevention and treatment drugs, and can solve the research on the prevention and treatment effect or clinical application of logan aglycone on autoimmune hepatitis. and other problems, to achieve the effect of reducing treatment costs, definite curative effect, and reducing damage

Pending Publication Date: 2021-04-20
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] So far, there is no research on the prevention and treatment effect or clinical application of loganin on autoimmune hepatitis

Method used

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  • Purpose of loganin in preparation of medicine used for preventing and treating autoimmune hepatitis
  • Purpose of loganin in preparation of medicine used for preventing and treating autoimmune hepatitis
  • Purpose of loganin in preparation of medicine used for preventing and treating autoimmune hepatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation Example 1 Loganinin Injection

[0031]

[0032] Preparation process: Mix the prescribed amount of ethanol and Tween-80 evenly, add loganin, stir to dissolve, add water for injection to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

Embodiment 2

[0033] Preparation Example 2 Loganin Injection

[0034] Loganin 10g

[0035] Ethanol 3.3L

[0036] Add water for injection to 10L

[0037] Preparation process: add the prescribed amount of ethanol to loganin, stir to dissolve, add water for injection to 10L, stir evenly, add 0.5% activated carbon for needles, stir, and decarbonize to obtain the product.

Embodiment 3

[0038] Preparation Example 3 Loganinin Injection

[0039]

[0040]

[0041] Preparation process: mix the prescribed amount of propylene glycol and ethanol evenly, add loganin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% activated carbon for needles, stir, and decarbonize to obtain .

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PUM

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Abstract

The invention belongs to the medicine field, and particularly relates to a purpose of loganin in preparation of a medicine used for preventing and treating autoimmune hepatitis. In order to overcome the technical problems that an existing immunosuppressant has a poor treatment effect for the autoimmune hepatitis and has a huge side effect, the invention provides an autoimmune hepatitis treatment medicine which takes the loganin as a main active ingredient. When the medicine used for preventing and treating the autoimmune hepatitis is used for treating the autoimmune hepatitis, the medicine used for preventing and treating the autoimmune hepatitis not only can recover liver functions and lower liver indexes but also can obviously improve the levels of interleukin-2 and [gamma]-interferon and lower the levels of interleukin-4 and interleukin-6, the medicine used for preventing and treating the autoimmune hepatitis has the characteristics of obvious curative effects and small adverse reaction when the medicine is used for treating the autoimmune hepatitis, and the medicine is suitable to be prepared into clinical autoimmune hepatitis treatment medicine.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the medical use of loganin, in particular to the use of loganin in the preparation of medicines for preventing and treating autoimmune hepatitis. Background technique [0002] Autoimmune hepatitis is a liver tissue injury caused by the expression of specific or non-specific autoantigens, and is a chronic inflammatory disease of the liver with unknown etiology. The clinical features of this disease are liver function damage, increased plasma immunoglobulin, and the presence of various autoantibodies in the blood circulation. Autoimmune liver diseases such as chronic cholangitis (PSC) often overlap in clinical manifestations, biochemical, immune and histological changes, making the clinical diagnosis and treatment of autoimmune hepatitis quite difficult. The International Autoimmune Hepatitis Conference held in 1992 formulated the diagnostic criteria for AIH: 1. Hypergammaglobulinemia; 2. Spe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P1/16A61P37/04
Inventor 张贵民李光艳徐燕
Owner LUNAN PHARMA GROUP CORPORATION
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