Three-dimensional ultrasonic array scaffold-free cell printing device and printing process thereof

Abstract

The invention provides a three-dimensional ultrasonic array scaffold-free cell printing device and a printing process thereof. The three-dimensional ultrasonic array scaffold-free cell printing device comprises a cell conveying mechanism, a printing platform, a platform driving mechanism, a conveying driving mechanism and a three-dimensional ultrasonic array micro potential well generation system, wherein the printing platform is installed on the platform driving mechanism; the cell conveying mechanism is installed on the conveying driving mechanism; the three-dimensional ultrasonic array micro potential well generation system is connected with the printing platform; a planar sound pressure micro potential well is formed in the printing platform; a plurality of planar sound pressure micro potential wells with different heights are formed on the printing platform, so that cells needing to be printed at different heights are positioned; and a cell three-dimensional system is constructed in the mode of constructing a three-dimensional array sound pressure potential well, controllability is better, and the three-dimensional ultrasonic array scaffold-free cell printing device can be used for cell three-dimensional printing under various cells and various environments and has excellent universality.

Description

technical field [0001] The invention belongs to the fields of biomanufacturing and cell printing, and in particular relates to a three-dimensional ultrasonic array scaffold-free cell printing device and a printing process thereof. Background technique [0002] Cell / biological 3D printing assembles three-dimensional cells by gradually depositing living cells, extracellular matrix, biological factors and necessary biological materials, constructs a biologically active three-dimensional multicellular system in vitro, and then achieves tissue regeneration and organ repair through culture and propagation It is an effective way to solve the dilemma of traditional tissue engineering, and it is of great significance to the development of life science and biomedicine. [0003] In cell printing technology, the primary problem to be solved is how to accurately deposit a set number of specific cells to a preset position in a three-dimensional space, that is, how to construct a three-dim...

AI Technical Summary

Problems solved by technology

However, the existing scaffold-free cell printing technology still needs to use agar rods as physical supports during the cell printing process.

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