Method for detecting foreign matters in disposable syringe

Abstract

The invention discloses a method for detecting foreign matters in a disposable syringe. The method comprises the following steps that S1, the disposable syringe is cleaned and dried; S2, the disposable syringe dried in the step S1 is conveyed to a scratch detection area, and scratches on the inner wall and the outer wall are rapidly detected; S3, when qualified products detected in the step S2 are output to the scratch detection area, wall thickness information of different positions of the same disposable syringe is rapidly detected and collected through a plurality of contacts of a wall thickness detector, data information is transmitted to a background, and data differences are compared; S4, the disposable syringes detected to be qualified in the step S3 are continuously conveyed to pass through the detection channel of the light transmittance instrument; S5, the disposable syringe is filled with liquid medicine and sealed through plug pressing; and S6, finally, the disposable syringe is conveyed into intelligent foreign matter detection equipment for foreign matter detection. According to the method, surface scratches, wall thickness uniformity and light transmittance of the container are detected, good accuracy and high efficiency of subsequent foreign matter detection are guaranteed, and practicability is higher.

Description

technical field [0001] The invention belongs to the technical field of foreign matter detection, and in particular relates to a method for detecting foreign matter inside a disposable syringe. Background technique [0002] From the analysis of the pharmaceutical process, there are many links in which insoluble foreign matter is produced, and the types are also different, as shown. The main causes of insoluble foreign matter are: (1) impurity of raw and auxiliary materials introduces insoluble foreign matter pollution. (2) The non-dissolved foreign matter pollution introduced by the shedding of packaging materials during the packaging process. (3) The aging of manufacturing equipment or the unreasonable introduction of insoluble foreign matter pollution by process operation. (4) Production environment pollution, a large number of particles such as dust, soot, pollen, lumps, etc. suspended in the air; [0003] Once the insoluble particles are injected into the human body, t...

AI Technical Summary

Problems solved by technology

The main causes of insoluble foreign matter are: (1) impure raw materials and auxiliary materials introduce insoluble foreign matter pollution

(2) Non-dissolved foreign matter pollution caused by the shedding of packaging materials during the packaging process

(3) Aging of manufacturing equipment or unreasonable introduction of non-dissolved foreign matter pollution by process operation

[0003] Once the insoluble particles are injected into the human body, they will be blocked in the capillaries, causing adverse reactions such as phlebitis, thrombus, local oxygen shortage, edema, etc., and with the accumulation of insoluble foreign matter , will cause the proliferation of macrophages and form granulomas, which will lead to major diseases such as pulmonary fibrosis, cancer, organ failure, etc., seriously and persistently endanger human health, and even directly endanger life

[0004] Therefore, in order to avoid such accidents, it is necessary to use intelligent foreign object detection equipment. After rotating the container, it will stop, and the internal solution will continue to rotate. The container will be illuminated by parallel light, and a CCD sensor will be installed on the other side of the container to detect the liquid from the parallel light source and the photosensitive chip. When there is no particle blocking in the liquid, the brightness sensed by the photosensitive chip is uniform; however, when the insoluble particles mixed in the liquid pass through, the insoluble particles will block the parallel light, resulting in the blocking part and the non-blocking part There is a difference in brightness, and the highly sensitive CCD / CMOS photosensitive chip converts the light signal into an electrical signal, and the presence or absence of insoluble particles can be judged by analyzing the brightness difference of the data, so this means that the scratches on the container surface, the uniformity of the wall thickness and the The light transmittance will affect the reception of the light source by the CCD sensor, resulting in detection errors. In the traditional detection method, there is no corresponding detection step for the three, and there is a certain error rate.