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Traditional Chinese medicine composition for reducing somatic cell count in milk and preparation method thereof

A somatic cell and composition technology, which is applied in the field of traditional Chinese medicine compositions for reducing the number of somatic cells in milk and the field of preparation thereof, can solve the problems of reducing the number of somatic cells in milk, reducing the milk body, and failing to repair damage to breast tissue, etc. The effect of reducing the number of milk somatic cells, reducing the number of somatic cells, and repairing breast tissue damage

Pending Publication Date: 2021-07-16
章国忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Antibiotic treatment and traditional Chinese medicine clearing heat and removing blood stasis have no effect on repairing the damage of breast tissue, so they are not effective in reducing the number of somatic cells in milk
[0010] At present, there is no effective drug to reduce the number of somatic cells in milk, so there is an urgent need for a drug that can treat or prevent excessive somatic cells in milk and solve major problems in the dairy industry

Method used

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  • Traditional Chinese medicine composition for reducing somatic cell count in milk and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation steps of the traditional Chinese medicine composition for reducing the number of somatic cells in milk of the present invention in perfusion dosage form are as follows:

[0032] Step 1: Weigh the raw materials according to the formula, pulverize the raw materials, put them in the microwave extraction equipment, heat them to a surface temperature of 60°C, repeat the microwave radiation three times, then add purified water equal to the quality of the raw materials, reflux and filter, The filtrate was left to stand for more than 48 hours to obtain liquid A, which was set aside;

[0033] Step 2: Take the raw material after the extraction treatment in step 1, carry out normal pressure low-temperature dry distillation in an external heating type dry distillation device, the low temperature is 100-120°C, and then carry out redistillation in an oil bath at 135°C, and take the redistilled whole The distillate was left to stand for 48 hours to obtain liquid B for ...

Embodiment 2

[0036] The preparation steps of the traditional Chinese medicine composition for reducing the number of somatic cells in milk of the present invention in oral liquid dosage form are as follows:

[0037] Step 1: According to the raw materials weighed by the formula, add distilled water with a weight ratio of 10 times, add water to soak for 2 hours, decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, and filter;

[0038] Step 2: Concentrate the filtrate obtained in step 1 under reduced pressure at 60°C to a relative density of 1.08, refrigerate for 24 hours, and then filter, add 1% chitosan in 2% acetic acid solution at a volume ratio of 10:1, fully Clarify, filter, add 3g of sodium benzoate to the filtrate, add water to 1000mL, mix evenly, fill and sterilize, and obtain the traditional Chinese medicine composition for reducing the number of somatic cells in milk in oral liquid dosage form.

Embodiment 3

[0040] The preparation steps of the traditional Chinese medicine composition for reducing the number of somatic cells in milk of the present invention in granule dosage form are as follows:

[0041] Step 1: According to the raw materials weighed by the formula, add distilled water with a weight ratio of 10 times, add water to soak for 2 hours, decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, and filter;

[0042] Step 2: Concentrate the filtrate obtained in step 1 under reduced pressure at 60°C to a relative density of 1.28-1.30 to obtain a clear paste, then make granules with clear paste, sugar, and dextrin at a ratio of 1:3.5:1, and dry , made into 350g to obtain the traditional Chinese medicine composition for reducing the number of somatic cells in milk in the form of granules.

[0043] The performance of the traditional Chinese medicine composition perfusate prepared in Example 1 is tested by experiments below.

[0044] 1. Anima...

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Abstract

The invention provides a traditional Chinese medicine composition for reducing the number of somatic cells in milk and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following ingredients in parts by mass: 0.05 to 20 parts of radix angelicae sinensis, 0.05 to 20 parts of radix paeoniae rubra, 0.05 to 20 parts of radix astragali seu hedysari, 0.05 to 20 parts of radix codonopsis, 0.05 to 20 parts of radix rehmanniae, 0.05 to 20 parts of radix scrophulariae, 0.05 to 20 parts of cortex cinnamomi, 0.05 to 20 parts of radix aconiti carmichaeli preparata, 0.1 to 40 parts of radix et rhizoma rhei, 0.1 to 40 parts of tribulus terrestrisL, 0.05 to 20 parts of semen coicis, 0.05 to 20 parts of radix crotonis crassifolii, 0.05 to 20 parts of rhizoma coptidis, 0.05 to 20 parts of caulis akebiae, 0.05 to 20 parts of fructus aurantii immaturus and 0.05 to 20 parts of herba patriniae. The traditional Chinese medicine composition can effectively treat clinical mastitis and recessive mastitis of dairy cows, repair breast tissue damage and achieve the effect of reducing the number of somatic cells in milk.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for reducing the number of somatic cells in milk and a preparation method thereof. Background technique [0002] Somatic cells in milk refer to cells derived from the bovine body. Somatic cells are mainly composed of white blood cells and exfoliated epithelial cells. Under normal circumstances, a small number of white blood cells and epithelial cells can enter the milk through the mammary gland, and a certain number of white blood cells in milk have the function of resisting foreign microorganisms. However, when pathogenic bacteria invade, the body will release a large number of white blood cells to the mammary gland, mainly including macrophages, lymphocytes, neutrophils or neutrophil polymorphonuclear granulocytes. The so-called somatic cell count (SCC) refers to the result of detecting the number of somatic cel...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P15/14
CPCA61K36/232A61K36/71A61K36/65A61K36/481A61K36/344A61K36/804A61K36/808A61K36/54A61K36/714A61K36/708A61K36/185A61K36/8994A61K36/47A61K36/718A61K36/752A61K36/84A61K9/0041A61P15/14A61K2236/331A61K2300/00
Inventor 章国忠柴书霞陈保立王运升刘晓勇
Owner 章国忠
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