Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of chicken bone extract in preparation of medicines for preventing and/or treating ulcerative colitis

A technology of ulcerative colitis and chicken bone incense is applied in the field of biomedicine to achieve the effects of improving colon inflammation, relieving colon shortening and reducing cell infiltration

Active Publication Date: 2022-04-05
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Experimental studies have shown that both the alcohol extract and the water extract of the chicken bone have anti-inflammatory effects. In addition, patents CN110294766A and CN110540530A have disclosed that the root extract of the chicken bone has anti-tumor activity, but the current research on the effect of the chicken bone on ulcerative colitis The effect has not been reported yet and needs to be developed and researched

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of chicken bone extract in preparation of medicines for preventing and/or treating ulcerative colitis
  • Application of chicken bone extract in preparation of medicines for preventing and/or treating ulcerative colitis
  • Application of chicken bone extract in preparation of medicines for preventing and/or treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation of embodiment 1 Jiguxiang extract

[0048] Take 1250g of Jiguxiang medicinal material, add 10 times the weight of 95% (volume) ethanol respectively, heat and reflux at 60°C for 2h, 1h, and 45min for 3 extractions, filter, combine the reflux liquid and concentrate it into a thick paste, freeze-dry under reduced pressure Obtain the chicken bone extract afterward.

Embodiment 2

[0050] 1. Experimental method

[0051] 1. Establishment and administration of experimental animal models of ulcerative colitis

[0052] All C57BL / 6 mice were of SPF grade and were adaptively fed for one week. They were reared at a temperature of 25±1°C, a humidity of 55±5%, and a 12-hour day-night cycle. Experimental animals were randomly divided into 5 groups, 6 animals in each group, free to eat and drink.

[0053] (1) Control group (Control group): All mice drank sterile distilled water freely, and fed a corresponding volume of CMC-Na solution for 10 days;

[0054] (2) Model group (DSS group): Mice were given 3% DSS aqueous solution to drink freely for 7 days, and fed with a corresponding volume of CMC-Na solution for 10 consecutive days, once a day;

[0055] (3) Mesalazine group (Mesalazine group): the mice were given 3% DSS aqueous solution to drink freely for 7 days, and the corresponding volume of mesalazine (100 mg / kg, ground into mesalazine enteric-coated tablets) ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses the application of the extract of Jiguxiang in the preparation of medicines for preventing and / or treating ulcerative colitis. The research of the present invention found that the extract of chicken bone incense can significantly relieve symptoms such as colon shortening, colon injury, diarrhea and blood in the stool, reduce tissue inflammatory cell infiltration, and reduce colon inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX‑2), which indicated that the extract of Jiguxiang could alleviate ulcerative colitis by protecting the inherent structure of colonic tissue and improving colonic inflammation, thus providing a novel therapeutic agent for the prevention and / or treatment of ulcerative colitis. Natural medicine options.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to the application of the extract of Jiguxiang in the preparation of medicines for preventing and / or treating ulcerative colitis. Background technique [0002] The incidence of ulcerative colitis (UC) is increasing year by year in the world, and the incidence in our country also has an increasing trend. The pathogenesis of UC is still unclear, mainly involving genetic susceptibility, epithelial barrier defect, immune response dysregulation, and environmental factors. The disease is a chronic inflammation of the intestinal mucosa. The lesion is mostly in the rectum and can even spread to the proximal colon. The main clinical manifestations are bloody diarrhea, abdominal pain, blood in the stool, and weight loss. UC has a long course of disease and is prone to recurrent attacks, and may even develop into colon cancer. It is recognized by the WHO as a modern refra...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/47A61P1/04
CPCA61K36/47A61P1/04A61K2236/333A61K2236/51
Inventor 赵钟祥崔辉江诗琴杨伟群沈秀婷
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com