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Heart rate decreasing agent

A technology for lowering agents and heart rate, which is applied in the fields of cardiovascular system diseases, pharmaceutical formulations, respiratory diseases, etc., can solve problems that have not received much attention and poor prognosis, and achieve the effect of improving prognosis and reducing heart rate

Pending Publication Date: 2021-08-17
FURUKAWA RES OFFICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] On the one hand, although heart rate is one of the vital signs as important as blood pressure, respiratory rate, body temperature, and consciousness, it has not received much attention so far, because in the case of cardiovascular disease, the higher the heart rate, the worse the prognosis, or in Heart rate is attracting attention as one of the important biomarkers of cardiovascular disease, as the prognosis is improved when the heart rate decreases in heart failure or ischemic heart disease, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Oral uptake of a tablet containing lactic acid, the change in heart rate was measured before the oral uptake and orally taken. The subject is a 62-year-old male, which is pointed out in the health diagnosis of cholesterol, but there is no previous medical history, and the blood pressure is the range of normal values. There is no problem in diagnosis of blood pressure. The heart rate is slightly higher in 89 to 92 / min, and the heart rate is almost not less than 86 / minute in quiet.

[0104] Since the heart rate will rise immediately due to exercise or tension, the measurement date may be spent on the work, and the chair is more than a few minutes, and it is determined in a stable state.

[0105] Drinking 2 cans of beer every day, 2 to 3 cups of double-grained wine, the heart rate after drinking is rising from 105 to 115 / minute (occasionally to 120 / min), feel drunk and slightly palpitations. It will feel sleepy ahead.

[0106] Male of the subject was administered intra...

Embodiment 2

[0114] 12 people exercising every day to exercise as a subject, verify the reduction in heart rate in the exercise of the lotion.

[0115] Each subject is taken up by 2 sheets of the chewable piece of lactic acid in the oral cavity before exercising 2 hours ago.

[0116] The intensity of each person is set in a manner that reaches a heart rate of 30% + 20 bpm. The intensity intensity is obtained by the above Kaun's formula. This motion intensity corresponds to 11 to 13 of the subjective intensity (Borg Index, Borg Scale), is a value close to aerobic threshold.

[0117] Each of the subjects were measured every 10 minutes to exercise for 40 minutes.

[0118] Further, in order to compare the week before the above test, the above-described test is performed, similarly to the above-described test, the same movement, the same movement, the same movement is performed as the above test. Put the results figure 1 .

[0119] figure 1 The vertical axis represents the heart rate. In addition,...

Embodiment 3

[0126] In the 30-year-old male in the marathon athlete, the heart rate reduction effect in the marathon was verified.

[0127] As the exercise run, the subject is running 52 minutes and 44 seconds per km in a state of 4 minutes, 44 seconds per km, and the heart rate of the GARMIN is measured with GARMIN. Putting its results in Table 3 and figure 2 .

[0128] [table 3]

[0129] Total time (ratio) Heart rate interval 5 (heart rate 169 or more) 18 minutes 55 seconds (36%) Heart rate interval 4 (150 ~ 168) 22 minutes 40 seconds (43%) The following (132-49) 10 minutes 54 seconds (20%)

[0130] On the other day of the marathon competition (full marathon), 2 pieces containing 200 mg of the lactic acid 200 mg were dissolved within the oral cavity 1 hour ago. Then, attend the competition, running at an average step 4 minutes 48 seconds / km, 3 hours and 24 minutes 33 seconds, and the heart rate between it is also determined. The result is shown in Table 4 and ...

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Abstract

The present invention addresses the problem of providing a heart rate decreasing agent having fewer adverse side effects or a novel agent for suppressing the increase in a heart rate during exercise. A heart rate can be decreased, particularly palpitation, breath shortness or a feeling of fatigue associated with the increase in a heart rate can be prevented or ameliorated and the increase in a heart rate during exercise can be suppressed by ingesting a preparation containing orotic acid or a salt thereof as an active ingredient.

Description

Technical field [0001] The present invention relates to a heart rate reduction agent containing a carotic acid or a salt (hereinafter, sometimes referred to as "lactic acid") as an active ingredient, a prevention or improvement agent of a heart, asthma or fatigue, a sense of heart rate, and exercise Heart rate rising inhibitor. Background technique [0002] Laqing acid (also known as ovarrin acid, uracil-6-carboxylic acid, oortic acid or vitamin B13) is a major intermediate substance in a pyrimidine nucleotide biosynthesis system, from dihydrochloric acid by dihydrochloric acid Dehydrogenase induction, is a lactide acid by lactose phosphate-based transferase (PRPP). The ammonia is then rapidly transformed into urine phosphoric acid (UMP), and then a pyridine nucleotide such as uricine triphosphate and cytoside triphosphate is synthesized. [0003] In recent years, research on the physiological effects of lactic acid is being advanced. For example, it is known that the lactic acid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/513A61P9/00A61P9/04A61P11/00
CPCA61P9/04A61P9/00A61K31/513A61P11/00
Inventor 古川令
Owner FURUKAWA RES OFFICE CO LTD
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