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Application of Hedraaponin C in preparation of medicine for treating and preventing acute lung injury

A technology for acute lung injury and uses, applied in the field of medicine, can solve problems such as large toxic and side effects, and no specific drugs for ALI

Pending Publication Date: 2021-08-31
GUANGXI XINHAI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still no specific drug for the treatment of ALI
Although the use of glucocorticoids combined with mechanical ventilation has a good effect, but the side effects are large, and there will be serious sequelae after treatment.

Method used

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  • Application of Hedraaponin C in preparation of medicine for treating and preventing acute lung injury
  • Application of Hedraaponin C in preparation of medicine for treating and preventing acute lung injury
  • Application of Hedraaponin C in preparation of medicine for treating and preventing acute lung injury

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Embodiment Construction

[0022] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0023] It should be understood that terms such as "having", "comprising" and "including" as used herein do not entail the presence or addition of one or more other elements or combinations thereof.

[0024] It should be noted that the experimental methods described in the following embodiments, unless otherwise specified, are conventional methods, and the reagents and materials, unless otherwise specified, can be obtained from commercial sources.

[0025] 1 material

[0026] 1.1 Experimental animals

[0027] SPF grade healthy BALB / C mice, weighing 20-22g, 7-8 weeks old, male, were purchased from Hunan Slack Jingda Experimental Animal Co., Ltd. All experimental animals were raised in a controlled environment, room temperature 18-24°C, The humidity was 40%-50%. During the exp...

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Abstract

The invention discloses application of Hedraaponin C in preparation of a medicine for treating and preventing acute lung injury. The structural formula of the Hedraaponin C is shown in formula (I). The Hedraaponin C has a certain protection effect on mouse ALI caused by LPS, the effect of the Hedraaponin C is not only through reducing release of TNF-alpha, IL-6 and IL-1beta, and reducing accumulation of neutrophils, lymphocytes and leukocytes in lung tissue, but also relates to inhibition of activation of a PIP2 signal channel, an NF-kappa B signal channel and an NLRP3 inflammasome.

Description

technical field [0001] The invention relates to the technical field of medicine. More specifically, the present invention relates to the use of Hederasaponin C in the preparation of medicines for the treatment and prevention of acute lung injury. Background technique [0002] Acute lung injury (ALI) is a common clinical critical disease with high morbidity and mortality, which is caused by various direct or indirect pathogenic factors such as pathogenic microorganism infection, and is characterized by acute progressive respiratory Refractory hypoxemia is the main clinical syndrome. Acute interstitial inflammation such as neutrophil infiltration and accumulation of pro-inflammatory cells in the lungs of ALI can hinder pulmonary gas exchange. Therefore, if ALI is not treated in time, it can further develop into a more serious acute respiratory distress syndrome (ARDS), with a mortality rate as high as 40%. Endotoxin LPS infection can trigger a cytokine storm, which can lead...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P11/00A61P31/04A61P31/10A61P31/16
CPCA61K31/704A61P11/00A61P31/04A61P31/10A61P31/16
Inventor 高红伟杨世林
Owner GUANGXI XINHAI PHARM TECH CO LTD
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