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Application of cannabinoid molecules CBG in preparation of inflammatory pain drugs and medicinal preparation

A technology for inflammatory pain and cannabinoids, applied in the field of cannabinoid drugs, can solve problems such as unclear effects, achieve the effects of improving compliance and safety, strengthening social value, and reducing patient pain

Pending Publication Date: 2021-10-12
无锡诺平医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned GW invention patent discovered the effect of intraperitoneal injection (systemic administration) of cannabinoids (CBD / CBG / CBC / CBDV / THCV) in the treatment of neuralgia, but the effect on other pain types and other administration methods has not yet been clarified

Method used

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  • Application of cannabinoid molecules CBG in preparation of inflammatory pain drugs and medicinal preparation
  • Application of cannabinoid molecules CBG in preparation of inflammatory pain drugs and medicinal preparation
  • Application of cannabinoid molecules CBG in preparation of inflammatory pain drugs and medicinal preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Analgesic effect of different cannabinoids on inflammatory pain model mice

[0034] Clean-grade Kunming mice were purchased from Beijing Weitong Lihua Company; carrageenan was purchased from Sigma Company; castor oil, indomethacin, ibuprofen and aspirin were purchased from Adamas Company; acupuncture plantar pain tester was purchased from In Shenzhen Ruiwode Life Technology Co., Ltd.

[0035] Grouping: 30 Kunming mice (female) were randomly divided into normal group (normal saline, i.e. blank control group), model group (2% carrageenan), CBC group, CBD high-dose group, CBD low-dose group, CBG group, 5 rats in each group. The grouping and drug use are shown in Table 1.

[0036] Table 1

[0037]

[0038] Preparation of CBC, CBD, and CBG solutions: Weigh 4 mg of cannabinoid drug (CBC / CBD / CBG are self-made, purity >98%) and dissolve in 50 μL of ethanol, add 50 μL of polyoxyethylene castor oil (Titan, P1603588) Mix well, and then add 900 μL of purified water...

Embodiment 2CB

[0045] Example 2 Comparison of the analgesic effect of CBG and CBD on inflammatory pain model mice

[0046] Grouping: 80 mice were randomly divided into normal group, model group, CBD group and CBG group, with 20 mice in each group, 10 male and 10 male. The method of plantar drug administration was adopted. The left hind limb was injected with normal saline, and the right hind limb was injected with carrageenan. After 20 minutes, the left hind limb was injected with matrix, and the right hind limb was injected with corresponding drugs. Both hindlimbs of the normal group and the model group were injected with matrix. Acupuncture Methods to evaluate the analgesic effect of CBD and CBG. The grouping and medication status are shown in Table 2 below.

[0047] Table 2

[0048]

[0049] Preparation of CBD and CBG solutions: Weigh 4 mg of drug (both self-made CBD and CBG) powder and dissolve in 50 μL of ethanol, add 50 μL of polyoxyethylene castor oil (Titan, P1603588) and mix we...

Embodiment 3CB

[0056] Embodiment 3CBG and multiple positive drugs compare the analgesic effect of inflammatory pain model mice

[0057] Grouping: 96 Kunming mice were randomly divided into 6 groups, with a total of 16 males and females in each group, normal group, model group, model + CBG 2mg·kg -1 Group, model + indomethacin 2mg·kg -1 Group, model + aspirin 2mg·kg -1 Group, model + ibuprofen 2mg·kg -1 Group. In the model group, normal saline was injected into the left hind limb, and 1% carrageenan was injected into the right hind limb to induce inflammation. Each hind limb was injected with matrix, and the analgesic effect of CBG was evaluated by acupuncture. The grouping and drug use are shown in Table 3.

[0058] table 3

[0059]

[0060] Preparation of CBG and positive drug solution: Weigh 4 mg of drug (CBG is self-made) powder and dissolve in 50 μL of ethanol, add 50 μL of polyoxyethylene castor oil (Titan, P1603588) and mix well, then add 900 μL of purified water to obtain 4 m...

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Abstract

The invention discloses application of cannabinoid molecules CBG in preparation of inflammatory pain drugs and a medicinal preparation. Local administration experiments find that different cannabinoid molecules have different effects on inflammatory pain, and further find that the CBG effect is optimal and is stronger than the effect on SNI pain. Furthermore, the effective dose (0.25-3mg / kg) and the action time (60-140min) of the CBG are screened, and the effective dose (1-3mg / kg) and the action time (60-100min) of the CBG are optimized. Finally, animal arthritis model verification finds that the CBG can treat arthritis pain. The result shows that the cannabinoid molecules CBG are more suitable for treating inflammatory pain and can be developed into an external preparation.

Description

technical field [0001] The invention belongs to the technical field of cannabinoid drugs, and in particular relates to the application and medicinal preparation of the cannabinoid molecule CBG in the preparation of inflammatory pain drugs. Background technique [0002] The use of cannabinoid molecules in the treatment of pain is mainly the patent "cannabinoid compounds for the treatment of neuropathic pain" published by GW in 2012. This patent proposes the use of cannabinoids to treat neuropathic pain, including CBD / CBG / The five components of CBC / CBDV / THCV, and the analgesic activity of five cannabinoid molecules against SNI (sciatica) model mice were investigated and compared. The effect of kg is stronger than that of CBD. The patent of GW Company mainly constructs the SNI model, and then administers the drug every day (peritoneal administration) after the model is constructed, and measures the mechanical pain threshold or thermal pain threshold at 3, 7, and 14 days; the ...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K9/70A61P29/00A61P19/02
CPCA61K31/05A61K9/7023A61P29/00A61P19/02
Inventor 张建革李瑞翔林国强陈飚冯陈国付建国丁瑞
Owner 无锡诺平医药科技有限公司
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