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Novel small peptide IT-9 and application thereof

A IT-9, a new type of technology, applied in the field of new small peptides and their applications

Inactive Publication Date: 2021-10-22
HENAN AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No studies have been reported on the antifungal activity of unconventional peptides

Method used

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  • Novel small peptide IT-9 and application thereof
  • Novel small peptide IT-9 and application thereof
  • Novel small peptide IT-9 and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024] 1 Materials and methods

[0025] 1.1 Experimental materials

[0026] 1.1.1 Pathogenic bacteria

[0027] The umbilicalspora maize, Curvularia lunata and umbilicalsporium maize are all preserved by our laboratory.

[0028] 1.1.2 Medium

[0029] The medium used in this study was potato dextrose agar (PDA), configured as follows:

[0030] (1) 200g of fresh potatoes, peeled, cut into pieces and put into 1000ml of distilled water.

[0031] (2) After boiling in water for 20 minutes, filter with gauze.

[0032] (3) Add 20 g of sucrose and 20 g of agar powder to the filtrate, and add distilled water to make the volume to 1000 ml.

[0033] (4) After autoclaving at 121°C for 21 minutes, pour it onto a plate for later use.

[0034] 1.2 Experimental method

[0035] 1.2.1 Synthesis of unconventional peptides

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PUM

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Abstract

The invention discloses a novel small peptide IT-9. The amino acid sequence of the peptide IT-9 is ITACVHLPA. A broad-spectrum antifungal activity experiment of the peptide IT-9 shows that hyphae of Bipolaris zeicola and Curvularia lunata growing on a culture medium containing the peptide IT-9 have an abnormal branching phenomenon, but the phenomenon is not observed in a control culture medium without the peptide; it is indicated that the peptide IT-9 can achieve the inhibition effect on Bipolaris zeicola and Curvularia lunata by causing abnormal branches of hyphae. The peptide IT-9 has the highest inhibition rates of 83.6%, 79.8% and 59.2% respectively on Bipolaris zeicola, Curvularia lunata, and Bipolaris maydis.

Description

technical field [0001] The invention relates to a novel small peptide and its application, in particular to a novel small peptide with antibacterial activity against pathogenic fungi. Background technique [0002] Fungal plant pathogens are an important class of microorganisms that cause significant economic losses to agricultural production around the world. For decades, chemical pesticides have been commonly used to control the growth and spread of fungal pathogens. However, the use of pesticides not only pollutes the environment but also endangers human health, and the range of effects of pesticides is limited. Therefore, there is an urgent need to find a green, environmentally friendly and safe new fungicide to replace the currently used chemical pesticides. [0003] Peptides usually consist of 2 to 100 amino acid residues, and are small biomolecules that play important roles in organisms. According to their functions, small peptides can be divided into two categories...

Claims

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Application Information

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IPC IPC(8): C07K7/06A01N37/46A01N43/36A01P3/00
CPCC07K7/06A01N37/46A01N43/36
Inventor 吴刘记陈雪艳田磊陈彦惠
Owner HENAN AGRICULTURAL UNIVERSITY
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