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Detection method of ligusticum wallichii tea-blended dropping pills

A detection method and technology for Chuanxiong tea blending, which are applied in the directions of measuring devices, instruments, scientific instruments, etc., can solve the problem that the quality of the finished product of Chuanxiong tea dripping pills cannot be effectively controlled, the content determination of Chuanxiong and Qianghuo medicinal materials is not involved, and the thin-layer identification of Chuanxiong medicinal materials is not involved. The main spots are blurred and other problems, to achieve the effect of shortening the detection time, clear chromatogram spots, and clear spots

Active Publication Date: 2021-10-26
贵州健兴药业有限公司
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  • Application Information

AI Technical Summary

Problems solved by technology

However, in the actual detection, it was found that the detection method had the following defects: (1) the main spot for identifying the thin layer of Rhizoma Chuanxiong medicinal material was blurred, and there was a tailing phenomenon, the Rf value of the spot was too small, and the reproducibility was poor, which affected the judgment of the test result; (2) The TLC identification of notopterygium medicinal materials was not inspected in the original test item; (3) the content determination of Chuanxiong and notopterygium medicinal materials was not involved in the test item, and the quality of the finished product of Chuanxiong Chadiao dripping pills could not be effectively controlled
[0004] In order to solve the above problems, effectively improve product quality, and improve the quality standard of Chuanxiong Chatiao Dripping Pills, the team of the present invention conducted in-depth research and development on the original detection method of Chuanxiong Chatiao Dripping Pills, and established a method for Chuanxiong Chatiao Dripping Pills The detection method not only solves the problems of blurred spots and poor reproducibility in TLC identification of Rhizoma Chuanxiong, but also develops that the TLC identification conditions of Rhizoma Chuanxiong can be used to simultaneously identify notopterygium medicinal materials, which saves detection costs and improves detection efficiency; In order to effectively control the product quality of Chuanxiong Chatiao dripping pills, the invention team has gone through a lot of experimental research and established a method for the determination of ferulic acid content in dripping pills to further improve product quality standards

Method used

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  • Detection method of ligusticum wallichii tea-blended dropping pills
  • Detection method of ligusticum wallichii tea-blended dropping pills
  • Detection method of ligusticum wallichii tea-blended dropping pills

Examples

Experimental program
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Effect test

Embodiment 1

[0043] [Prescription] Chuanxiong 244.8g, Angelica dahurica 122.4g, Notopterygium 122.4g, Asarum 61.2g, Fangfeng 91.8g, Mint 489.6g, Nepeta 244.8g, Licorice 122.4g.

[0044] [Preparation method] The above eight flavors, Chuanxiong, Qianghuo, Asarum, Fangfeng, Mint, and Nepeta are steam-distilled to collect volatile oil; the distilled aqueous solution is collected in a different device; the dregs, Angelica dahurica, and licorice are decocted twice, each time After 2 hours, combine the decoction, filter, add distilled aqueous solution, concentrate to a clear paste with a relative density of 1.15 at 70°C, cool to room temperature, add ethanol to the concentrated solution to make the alcohol content reach 70%, stir well, and refrigerate After 24 hours, absorb the supernatant, recover ethanol, concentrate under reduced pressure to a thick paste with a relative density of 1.20 at 70°C, heat and melt polyethylene glycol 6000, add the above extract and volatile oil in sequence, stir wel...

Embodiment 2

[0068] [Prescription] Chuanxiong 244.8g, Angelica dahurica 122.4g, Notopterygium 122.4g, Asarum 61.2g, Fangfeng 91.8g, Mint 489.6g, Nepeta 244.8g, Licorice 122.4g.

[0069][Preparation method] The above eight flavors, Chuanxiong, Qianghuo, Asarum, Fangfeng, Mint, and Nepeta are steam-distilled to collect volatile oil; the distilled aqueous solution is collected in a different device; the dregs, Angelica dahurica, and licorice are decocted twice, each time After 2 hours, combine the decoction, filter, add distilled aqueous solution, concentrate to a clear paste with a relative density of 1.10 at 70°C, cool to room temperature, add ethanol to the concentrated solution to make the alcohol content reach 70%, stir well, and refrigerate After 24 hours, absorb the supernatant, recover ethanol, concentrate under reduced pressure to a thick paste with a relative density of 1.25 at 70°C, heat and melt polyethylene glycol 6000, add the above-mentioned extract and volatile oil in sequence,...

Embodiment 3

[0093] [Prescription] Chuanxiong 244.8g, Angelica dahurica 122.4g, Notopterygium 122.4g, Asarum 61.2g, Fangfeng 91.8g, Mint 489.6g, Nepeta 244.8g, Licorice 122.4g.

[0094] [Preparation method] The above eight flavors, Chuanxiong, Qianghuo, Asarum, Fangfeng, Mint, and Nepeta are steam-distilled to collect volatile oil; the distilled aqueous solution is collected in a different device; the dregs, Angelica dahurica, and licorice are decocted twice, each time After 2 hours, combine the decoction, filter, add distilled aqueous solution, concentrate to a clear paste with a relative density of 1.20 at 70°C, cool to room temperature, add ethanol to the concentrated solution to make the alcohol content reach 70%, stir well, and refrigerate After 24 hours, absorb the supernatant, recover ethanol, concentrate under reduced pressure to a thick paste with a relative density of 1.30 at 70°C, heat and melt polyethylene glycol 6000, add the above-mentioned extract and volatile oil in sequence...

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Abstract

The invention relates to a detection method of ligusticum wallichii tea-blended dropping pills. The detection method comprises the following steps: carrying out thin-layer identification inspection on ligusticum wallichii and notopterygium root medicinal materials in the dropping pill, and measuring the content of ferulic acid in the dropping pill. Through methodological investigation, the detection method has the effects of strong specificity, good durability, good recovery rate and the like, can effectively detect the quality condition of the ligusticum wallichii tea-blended dropping pill, and further improves the product quality.

Description

technical field [0001] The invention relates to the field of drug detection, in particular to a detection method for Chuanxiong Chatiao dripping pills. Background technique [0002] Chuanxiong Chatiao Dripping Pills, a product of Guizhou Jianxing Pharmaceutical Co., Ltd., are effective in dispelling wind and relieving pain. It is used for headache due to pathogenic wind, or aversion to cold, fever, and nasal congestion; it is good at treating Shaoyang and Jueyin headaches, and it is also used for migraines, nervous headaches, or headaches caused by traumatic sequelae, and insufficient blood supply to the brain. [0003] Chuanxiong Chatiao Dripping Pills were recorded in YBZ25332005-2009Z. The original testing items in the standard were: traits; TLC identification of Chuanxiong; TLC identification of hesperidin; TLC identification of Fangfeng; TLC identification of glycyrrhetinic acid; inspection; licorice Determination of acid content. However, in the actual detection, it ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90
CPCG01N30/90
Inventor 孙小鹦廖萍廖伟廖忠
Owner 贵州健兴药业有限公司
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