Method for establishing prediction model for survival benefit of gallbladder cancer patient after chemoradiotherapy

A technology for predicting models and establishing methods, applied in the field of diagnosis and prediction, can solve the problems of predicting the prognosis of GBC patients, lack of in-depth research on the difference in efficacy of postoperative chemotherapy, chemotherapy combined with radiotherapy, etc., and achieve the effect of simple operation process and objective and accurate results

Pending Publication Date: 2021-10-26
ZHONGSHAN HOSPITAL FUDAN UNIV
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Problems solved by technology

In addition, there is a lack of in-depth research on the differences in the efficacy of postoperative chemotherapy and chemotherapy combined with radiotherapy, and there is currently no good method to predict the prognosis of GBC patients receiving chemotherapy or chemotherapy combined with radiotherapy

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  • Method for establishing prediction model for survival benefit of gallbladder cancer patient after chemoradiotherapy
  • Method for establishing prediction model for survival benefit of gallbladder cancer patient after chemoradiotherapy
  • Method for establishing prediction model for survival benefit of gallbladder cancer patient after chemoradiotherapy

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Embodiment Construction

[0033] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments. This embodiment is carried out on the premise of the technical solution of the present invention, and detailed implementation and specific operation process are given, but the protection scope of the present invention is not limited to the following embodiments.

[0034] A method for establishing a prediction model for the survival benefit of patients with gallbladder cancer after radiotherapy and chemotherapy, the specific steps are as follows:

[0035] 1. Data collection: 2689 GBC patients who underwent surgery in the SEER database from 2004 to 2015 and 88 GBC patients who underwent surgery in Zhongshan Hospital Affiliated to Fudan University from 2016 to 2018 were collected. The following clinical and pathological data were collected: gender, age, degree of tumor differentiation, TNM stage, surgical method, number of dissected lymph nodes, p...

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Abstract

The invention relates to a method for establishing a prediction model for survival benefit of a gallbladder cancer patient after chemoradiotherapy, the method comprises the following steps: collecting data, calculating a tendency score PS by adopting a generalized enhancement model GBM, balancing the balance of each group of variables by adopting an inverse probability weighting method IPTW, drawing a Kaplan-Meier survival curve, comparing survival differences after different TNMs receive different adjuvant treatments by stages, so as to discover that patients with the gallbladder cancer in the III-IV stage can gain benefits from adjuvant therapy; dividing III-IV stage gallbladder cancer patient data into a modeling group and an internal verification group according to definite diagnosis time, using SPSS software, carrying out single-factor and multi-factor COX risk scale model analysis in sequence, obtaining a final variable, and incorporating the final variable into a final column graph model; drawing a column graph for predicting the OS for prediction; and extracting features by collecting conventional clinical pathological indexes of a patient. The result is objective and accurate, specific individuals are respectively predicted and analyzed, and credible prediction and analysis results are provided.

Description

technical field [0001] The invention relates to a diagnostic prediction technology, in particular to a method for establishing a prediction model for the survival benefit of patients with stage III-IV gallbladder cancer after radiotherapy and chemotherapy. Background technique [0002] Gallbladder cancer (GBC) is the fifth most common gastrointestinal tumor, with an annual incidence of 2 to 27 per 100,000. Although relatively rare, GBC is the most aggressive malignancy of the biliary tract, with a 5-year survival rate of approximately 5%. Surgical resection is the only treatment for GBC. However, the recurrence rate after complete resection is high, often leading to poor prognosis. Therefore, postoperative chemotherapy, chemotherapy combined with radiotherapy and other adjuvant treatments are applied to GBC patients to improve the prognosis of patients. [0003] However, due to the low incidence of GBC, the indications for adjuvant therapy for GBC and the differences in t...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/50G16H20/40G16H50/70
CPCG16H50/50G16H20/40G16H50/70
Inventor 刘厚宝万文泽倪小健
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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