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Non-invasive imaging screening and minimally invasive sampling nucleic acid typing combined detection system

A technology that combines detection and analysis systems, applied in the determination/inspection of microorganisms, nuclear methods, medical images, etc., to avoid infection, reduce dead volume, and reduce consumption.

Pending Publication Date: 2021-11-19
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, these traditional Chinese medicine technologies are rarely developed into precise instruments and equipment, let alone combined with advanced methods such as artificial intelligence and big data to make them have stronger vitality. At the same time, there is no personalized system for typical diseases like lung cancer. Non-invasive quick intelligent diagnosis

Method used

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  • Non-invasive imaging screening and minimally invasive sampling nucleic acid typing combined detection system
  • Non-invasive imaging screening and minimally invasive sampling nucleic acid typing combined detection system
  • Non-invasive imaging screening and minimally invasive sampling nucleic acid typing combined detection system

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Embodiment 1

[0065] Such as figure 1 As shown, the combined detection system of non-invasive imaging screening and minimally invasive sampling nucleic acid typing provided in this embodiment includes non-invasive telecentric imaging screening No-Invasive Imaging, minimally invasive sampling nucleic acid accurate typing detection MinimalInvasive Typing, artificial intelligence and Big data analysis AI-Bigdata Analysis, interactive display terminal Handset and cloud medical resource network server MEDNET.

[0066] The combined detection system of non-invasive imaging screening and minimally invasive sampling nucleic acid typing provided in this embodiment includes a non-invasive telecentric imaging health analysis system and a minimally invasive sampling multi-channel nucleic acid amplification parallel detection system.

[0067] The non-invasive telecentric imaging health analysis system is configured to take images of the subjects' eyes, faces, tongues, palms and other parts of the human b...

Embodiment 2

[0115] Minimally invasive sampling for accurate typing of nucleic acid uses a minimally invasive sampling multi-channel nucleic acid amplification parallel detection system, and uses methods such as bronchoscopy or puncture to obtain biopsy tissue samples the size of a grain of rice (2-3 mm in size on one side) or scrape some epidermis from the lesion Or debris samples, and then put the minimally invasive sample directly into a fully integrated sample preparation nucleic acid analysis unit, after a series of automated biochemical reaction processing, finally obtain precision medical molecular typing indicators or multiple physiological and pathological change indicators The results of parallel detection and analysis, the specific process includes:

[0116] S1. The original sample Tissue of minimally invasive sampling is directly added to the fully integrated sample preparation nucleic acid analysis unit UTAS from the injection port;

[0117] S2. In the pretreatment area YC, on...

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Abstract

The invention relates to a non-invasive imaging screening and minimally invasive sampling nucleic acid typing combined detection system. The system comprises a non-invasive telecentric imaging health analysis system and a minimally invasive sampling multi-channel nucleic acid amplification parallel detection system; the non-invasive telecentric imaging health analysis system is configured to shoot a local surface image of the subject and perform machine learning and clustering analysis on the shot local surface image of the subject to obtain the subject with image feature abnormal change; the minimally invasive sampling multi-channel nucleic acid amplification parallel detection system is configured to perform minimally invasive sampling on a subject with abnormal change of image features, and perform detection and analysis of medical molecular typing indexes or physiological and pathological change indexes on the minimally invasive sampling to obtain specific gene detection results of the typing indexes or the physiological and pathological change indexes. According to the system, artificial intelligence conjoint analysis is carried out by combining detection results of noninvasive telecentric imaging screening and minimally invasive sampling nucleic acid accurate typing, mutual investigation is carried out, the probability of missing detection of a single method is reduced, the accuracy of detection and identification is improved, and the onset risk condition is evaluated or predicted and early-warned.

Description

technical field [0001] The invention relates to a combined detection system of noninvasive imaging screening and minimally invasive sampling nucleic acid typing, and relates to the technical fields of medical molecular diagnosis and traditional Chinese medicine health analysis. Background technique [0002] According to the estimates of the International Cancer Research Center (IARC), in 2018, there were 2,093,900 new cases of lung cancer and 1,761,000 new deaths in the world. my country is a big country in cigarette sales, and the incidence and mortality of lung cancer have always been higher than other countries in the world. Studies have found that if the tumor has not spread, the 5-year survival rate can reach 56%, but only 16% of patients can be diagnosed in the early stage; once the tumor spreads and metastasizes, the 5-year survival rate of lung cancer patients is only about 18.6%, more than half of patients die within 1 year of diagnosis. Therefore, to control lung...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H30/20G16H50/20G06K9/00G06K9/32G06K9/34G06K9/62G06N3/04G06N3/08G06N20/10C12Q1/6848C12Q1/6886
CPCG16H30/20G16H50/20G06N3/08G06N20/10C12Q1/6886C12Q1/6848C12Q2600/158G06N3/045G06F18/23G06F18/2411C12Q2523/32C12Q2547/10C12Q2563/107C12Q2565/629
Inventor 黄国亮林雪吕文琦杜文莉单晓晖符荣鑫
Owner TSINGHUA UNIV
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